Review
Biochemistry & Molecular Biology
Farzad Sadri, Zohreh Rezaei, Mohammad Fereidouni
Summary: This review summarizes the molecular signature of the SDF-1/CXCR4 pathway and explains how this axis is involved in normal events.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Martyna Parol-Kulczyk, Arkadiusz Gzil, Joanna Ligmanowska, Dariusz Grzanka
Summary: The tendency for chronic inflammation to convert into malignancy is a characteristic trait of tumors that promotes their progression to the metastatic stage. Inflammatory cells within the tumor communicate with cancer cells and become cells that support tumor growth. Epithelial-mesenchymal transition (EMT) is a program that allows malignant cells to switch into a metastatic form, enabling them to loosen cell-cell adhesion and enhance migratory and invasive features. Tumor cells that undergo EMT become more aggressive and resistant to apoptosis. Furthermore, malignant cells can stimulate the production of proinflammatory factors through the EMT program. Chronic inflammation is responsible for inducing EMT in malignancies. Developing tumors induce inflammatory responses by releasing cytokines, chemokines, and growth factors, which recruit populations of infiltrating immune cells to the tumor microenvironment. This inflammatory reaction potentially exerts tumor control but can also be intercepted by the tumor to stimulate its own development towards a metastatic form. Our study confirmed that the SDF-1 chemokine and its receptors, CXCR4 and CXCR7, may contribute to the initiation of metastasis formation and the EMT process.
Article
Oncology
F. Luo, Y. Su, Z. Zhang, J. Li
Summary: The study demonstrated the involvement of the SDF-1/CXCR4 axis in the homing and promotion of proliferation and migration of BMMSCs in prostate cancer. Increasing SDF-1 concentrations up-regulated CXCR4 expression, leading to enhanced proliferation and migration of BMMSCs. The presence of VECs in a non-contact co-culture model also facilitated BMMSC proliferation and migration.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Correction
Cell Biology
Quan-Jun Deng, Xiao-Feng Xu, Jing Ren
Summary: There was an error in the positive control group of Figure 8 in the original version of the article.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Daniel J. Sprague, Anthony E. Getschman, Tyler G. Fenske, Brian F. Volkman, Brian C. Smith
Summary: The CXCL12-CXCR4 signaling axis plays a critical role in development, immune function, and various diseases, including cancer and inflammatory diseases. A study has identified trisubstituted 1,3,5-triazines as competent ligands for the sY12-binding pocket of CXCL12, improving drug efficiency and offering new possibilities for therapeutic development and structural studies.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Endocrinology & Metabolism
Alexander Wilhelm, Isabelle Lemmenmeier, Alexandros Lalos, Alberto Posabella, Venkatesh Kancherla, Salvatore Piscuoglio, Tarik Delko, Markus von Fluee, Kathrin Glatz, Raoul Andre Droeser
Summary: This study found that the prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on the density of CD8 positive T-lymphocytes.
BMC ENDOCRINE DISORDERS
(2022)
Article
Oncology
Chunyan Ma
Summary: Adding bevacizumab to chemotherapy may have a positive impact on the treatment and prognosis of patients with epithelial ovarian cancer. It can significantly decrease the expression of related cancer markers and lower the recurrence rate, without significant safety concerns.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Juan Carlos Lopez-Gil, Laura Martin-Hijano, Patrick C. Hermann, Bruno Sainz Jr
Summary: This review summarizes the role of CXCL12 and its receptors in cancer stem cells and their niche, discusses therapeutic options, and highlights the need for a comprehensive review on the topic.
Article
Biochemistry & Molecular Biology
Maria Neves, Viviana Marolda, Federico Mayor, Petronila Penela
Summary: A better understanding of the crosstalk between key receptors and signaling pathways involved in cancer progression, specifically in breast cancer subtypes, is crucial for improving current therapies and addressing tumor microenvironment. This study examines the interplay between CXCR4/ACKR3 chemokine receptors and EGFR family signaling pathways in different breast cancer cell models and highlights their cooperation in promoting ERK1/2 activation, with potential implications for cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Feng Ju, Manar M. Atyah, Nellie Horstmann, Sheraz Gul, Razi Vago, Christiane J. Bruns, Yue Zhao, Qiong-Zhu Dong, Ning Ren
Summary: This review summarizes the latest findings on the morphology, signaling pathways, and interactions of cancer stem cell (CSC) niches, as well as the genetic and epigenetic modulations involved in CSC maintenance. The crosstalk between CSCs and their niche plays a crucial role in therapy resistance and recurrence.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Irene Del Molino Del Barrio, Annette Meeson, Katie Cooke, Mohammed Imad Malki, Ben Barron-Millar, John A. Kirby, Simi Ali
Summary: Breast cancer metastasis to lymph nodes is influenced by chemokine receptor CCR7 and its ligand CCL21, with the role of heparan sulphate in this process being investigated. Targeting chemokine-heparan sulphate interactions may present a promising therapeutic approach to inhibit metastasis.
Article
Oncology
Solmaz Khalighfard, Vahid Khori, Ebrahim Esmati, Farahnazsadat Ahmadi, Taghi Amiriani, Amirhoushang Poorkhani, Somayeh Sadani, Saeed Khodayari, Hamid Khodayari, Mohammad Reza Kalhori, Pedram Keshavarz, Ali Mohammad Alizadeh
Summary: Filgrastim, a recombinant G-CSF, can stimulate the migration of bone marrow-derived stem/progenitor cells to the bloodstream, which helps manage chemotherapy-induced leukopenia. However, our in vitro and in vivo experiments on 4T1 cells suggest that Filgrastim may increase cell migration, invasion, and metastasis, potentially increasing the risk of cancer cell metastasis in patients continuously receiving Filgrastim treatment.
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Xiaosong Li, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: Sequential transplantation of exosomes and pretreated MSCs can effectively promote cardiac repair post-AMI. Among them, the combination of pretreatment with hypoxia and TXL significantly enhances the CXCR4 level of MSCs, promotes recruitment, improves cardiac function, reduces infarct size, and enhances angiogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jinglong Shi, Ludi Fan, Bo Li, Chen Hu, Hui Pan
Summary: With changes in dietary habits, the incidence and mortality of colon cancer have increased significantly. Molecular mechanisms of SDF-1/CXCR4 and integrin alpha v beta 6 in liver metastasis of colon cancer are important factors affecting prognosis. The expression of alpha v beta 6 and SDF-1/CXCR4 are closely related to cancer cell differentiation and clinical TNM stage, indicating their potential as prognostic markers for colon cancer.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Pathology
Hailing Tang, Qianfa Long, Kun Zhuang, Kun Han, Xin Zhang, Hanqing Guo, Xiaolan Lu
Summary: RB1 was downregulated in gastric cancer cell lines, and overexpression of RB1 enhanced chemosensitivity to 5-FU in gastric cancer cells by regulating cell autophagy via the SDF-1/CXCR4 pathway. RB1 may serve as a promising therapeutic target in gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Transplantation
Paola Romagnani
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Transplantation
Hans-Joachim Anders, Anna Julie Peired, Paola Romagnani
Summary: The DAPA-CKD trial demonstrated that the SGLT2 inhibitor, dapagliflozin, attenuates the progression of chronic kidney disease (CKD) with proteinuria in patients with or without diabetes. This has significant implications for the understanding and treatment of CKD, suggesting that SGLT2 inhibition should be a central component in CKD management regardless of diabetes status. It may also impact the treatment approaches for IgA nephropathy and focal segmental glomerulosclerosis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Valerie A. Luyckx, Andrew D. Rule, Katherine R. Tuttle, Pierre Delanaye, Helen Liapis, Afschin Gandjour, Paola Romagnani, Hans-Joachim Anders
Summary: This article highlights the importance of kidney lifespan in understanding chronic kidney disease. Adaptive adjustments of nephrons are crucial for maintaining kidney function and structure, and the progression of kidney disease due to nephron loss is closely related to individual kidney function status.
NATURE REVIEWS NEPHROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Letizia De Chiara, Gianmarco Lugli, Gianluca Villa, Valentina Raglianti, Faeq Husain-Syed, Fiammetta Ravaglia, Paola Romagnani, Elena Lazzeri
Summary: This review discusses the mechanisms of chemotherapy-induced acute kidney injury, available biomarkers for early detection, and raises awareness of chemotherapy-induced acute kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pediatrics
Luigi Cirillo, Fiammetta Ravaglia, Carmela Errichiello, Hans-Joachim Anders, Paola Romagnani, Francesca Becherucci
Summary: Chronic kidney disease (CKD) is a global public healthcare concern in the pediatric population, with glomerulopathies being the second most common cause. Sodium-glucose transporter 2 inhibitors (SGLT2i) show promise in slowing the progression of CKD and glomerular diseases in children, although their use in this population is not yet approved.
PEDIATRIC NEPHROLOGY
(2022)
Letter
Immunology
Luigi Cirillo, Francesco Citera, Tommaso Mazzierli, Francesca Becherucci, Vito Terlizzi, Lorenzo Lodi, Elisa Buti, Paola Romagnani
Review
Cell Biology
Fiammetta Ravaglia, Maria Elena Melica, Maria Lucia Angelotti, Letizia De Chiara, Paola Romagnani, Laura Lasagni
Summary: Podocytopathies are a group of proteinuric glomerular disorders driven by primary podocyte injury, with various lesion patterns observed on kidney biopsy. Recent evidence suggests that these patterns represent signs of repeated injury and repair attempts, depending on the type, length, and severity of the podocyte injury, as well as the ability of parietal epithelial cells to drive repair processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Urology & Nephrology
Giorgio Trivioli, Elena Gelain, Maria L. Angelotti, Fiammetta Ravaglia, Marco Allinovi, Lorenzo Lodi, Leonardo Caroti, Annamaria Buccoliero, Giacomo Emmi, Marco Gattorno, Paola Romagnani, Stefano Volpi, Augusto Vaglio
Summary: ADA2 deficiency is a rare genetic disease that can cause various kidney manifestations and may be associated with type I interferon.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Immunology
Maud Tusseau, Ema Lovsin, Charlotte Samaille, Remi Pescarmona, Anne-Laure Mathieu, Maria-Cristina Maggio, Velma Selmanovic, Marusa Debeljak, Angelique Dachy, Gregor Novljan, Alexandre Janin, Louis Januel, Jean-Baptiste Gibier, Emilie Chopin, Isabelle Rouvet, David Goncalves, Nicole Fabien, Gillian Rice, Gaetan Lesca, Audrey Labalme, Paola Romagnani, Thierry Walzer, Sebastien Viel, Magali Perret, Yanick J. Crow, Tadej Avcin, Rolando Cimaz, Alexandre Belot
Summary: The interferon signaling in DNASE1L3 deficient patients is transient, unlike the anomalies observed in other diseases. DNASE1L3 deficiencies are associated with a broad phenotype including lupus nephritis and hypocomplementemic urticarial vasculitis.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Maria Elena Melica, Giulia Antonelli, Roberto Semeraro, Maria Lucia Angelotti, Gianmarco Lugli, Samuela Landini, Fiammetta Ravaglia, Gilda La Regina, Carolina Conte, Letizia De Chiara, Anna Julie Peired, Benedetta Mazzinghi, Marta Donati, Alice Molli, Stefanie Steiger, Alberto Magi, Niccolo Bartalucci, Valentina Raglianti, Francesco Guzzi, Laura Maggi, Francesco Annunziato, Alexa Burger, Elena Lazzeri, Hans-Joachim Anders, Laura Lasagni, Paola Romagnani
Summary: Crescentic glomerulonephritis is a disease characterized by vascular necrosis and hyperplasia of epithelial cells, resulting in the formation of crescents. Little is known about the molecular mechanisms driving this process. Research on mouse models showed that crescents are derived from the clonal expansion of immature parietal epithelial cells. Treatment with panobinostat, a histone deacetylase inhibitor, attenuated crescentic glomerulonephritis and restored kidney function by inducing differentiation of immature hyperplastic parietal epithelial cells into podocytes.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Transplantation
Lyuben Lyubenov, Chongxu Shi, Danyang Zhao, Luying Yang, Yutian Lei, Elmina Mammadova-Bach, Letizia de Chiara, Roberto Semeraro, Samuela Landini, Paola Romagnani, Elena Voerg, Satish K. Devarapu, Ricarda Welz, Stephan T. Kiessig, Hans-Joachim Anders
Summary: Cholesterol crystal (CC) embolism leads to acute kidney injury (AKI) and ischaemic cortical necrosis with high mortality. Injection of Glu-plasminogen (Glu-Plg) showed a dose-dependent attenuation of thrombotic angiopathy, GFR loss, and ischaemic necrosis in mice with CC embolism. Intermediate dose of Glu-Plg had transient protective effect, while high dose provided full protection without bleeding complications.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Carolina Conte, Giulia Antonelli, Maria Elena Melica, Mirko Tarocchi, Paola Romagnani, Anna Julie Peired
Summary: Chronic kidney disease (CKD) is a global health burden affecting over 840 million people worldwide. It presents sex disparities in its pathophysiology, epidemiology, clinical manifestations, and disease progression. While CKD is more frequent in females, males have a higher risk of progressing to end-stage kidney disease. Recent studies have highlighted the role of sex hormones in the development and progression of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Marco Allinovi, Francesco Sessa, Gianluca Villa, Andrea Cocci, Samantha Innocenti, Maria Zanazzi, Lorenzo Tofani, Laura Paparella, Dritan Curi, Calogero Lino Cirami, Riccardo Campi, Andrea Mari, Agostino Ognibene, Maria Lorubbio, Alessandra Fanelli, Stefano Romagnoli, Paola Romagnani, Andrea Minervini
Summary: The study aimed to identify and compare serum and urinary predictors for predicting long-term decline in glomerular filtration rate (GFR) after robotic Nephron-Spearing Surgery (rNSS). The results showed that patients who developed clinical acute kidney injury (AKI) had a more pronounced decline in eGFR at 24 months. KineticGFR at 4 hours and NephroCheck at 10 hours were found to be efficient predictors of post-operative AKI and long-term eGFR decline. Combining these biomarkers could help identify high-risk patients as early as 10 hours after surgery.
Article
Urology & Nephrology
Zhihui Zhu, Karoline A. T. Rosenkranz, Yoshihiro Kusunoki, Chenyu Li, Martin Klaus, Oliver Gross, Maria-Lucia Angelotti, Giulia Antonelli, Luigi Cirillo, Paola Romagnani, Nassim Bouteldja, Alireza Vafaei Sadr, Roman D. Buelow, Peter Boor, Hans-Joachim Anders
Summary: A preclinical study in mice suggests that triple blockade of RAS/SGLT2/MR may significantly improve renal outcomes in Alport syndrome and other progressive CKDs due to synergistic effects on the glomerular and tubulointerstitial compartments.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)