期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 25, 期 6, 页码 594-601出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2015.03.010
关键词
Adipokine; Sarcopenia; Physical function; Aging
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [21689018]
- Health Sciences Research Grants for Health Service from the Ministry of Health, Labor, and Welfare, Japan [H24-Choju-Ippan-005]
- Japan Arteriosclerosis Prevention Fund
- Center of Innovation Program from Japan Science and Technology Agency, JST
- Grants-in-Aid for Scientific Research [21689018] Funding Source: KAKEN
Background and aims: Population-based researches indicate that circulating adiponectin is inversely associated with muscle strength. However, interpretation of the findings has been limited by the use of a cross-sectional design. This study aimed to examine the prospective relationship between baseline circulating adiponectin concentration and change in muscular function-related physical performance in older adults. Methods and results: A 1-year prospective cohort study of Japanese community-dwelling elderly was conducted between 2002 and 2003. Four hundred thirty-four older persons participated in the measurements of physical function, including leg extension power, functional reach, timed up-and-go test, and 10-m maximum walking speed, at baseline and follow-up. After adjustment for potential covariates, higher serum adiponectin concentration was found to be significantly associated with poorer physical performance at baseline (leg extension power [watt], P < 0.001; functional reach [cm], P < 0.001; log timed up-and-go test, P = 0.007; log 10-m maximum walking speed, P < 0.001). The results of the prospective analysis by analysis of covariance indicated that the elderly with higher serum adiponectin concentrations (tertiles) at baseline tended to have a decreased performance in leg extension power (means [95% confidence interval]: lowest, -105 [-125, -85.7]; middle, -117 [-135, -97.8]; highest, -140 [-160, -120], watt, P for trend = 0.021) and timed up-and-go test (lowest, -0.08 [-0.28, -0.12]; middle, -0.10 [-0.29, 0.10]; highest, 0.28 [0.07, 0.48], s, P for trend = 0.019), but not two other functioning. Conclusion: High circulating adiponectin concentration may be an indicator of decreased physical performance, especially muscle strength, in older adults. (C) 2015 Elsevier B.V. All rights reserved.
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