Article
Engineering, Biomedical
A. Mialland, B. Kinsiklounon, G. Tian, C. Nous, A. Bonvilain
Summary: This study aims to detect swallowing using MMG signals from the submental area. Findings suggest that age and weight have a noticeable impact on timings. By placing benchmarks in the signals, a minimum average available time of 0.324 seconds was displayed.
Article
Computer Science, Theory & Methods
Shitong Mao, Aliaa Sabry, Yassin Khalifa, James L. Coyle, Ervin Sejdic
Summary: LV closure is crucial during swallowing to prevent food from entering the airway. This study introduces a non-invasive sensor-based system using deep learning to detect LV behaviors, achieving high accuracies in classifying LV statuses without traditional radiographic methods. These findings suggest the potential of sensor-supported systems for clinical diagnosis and biofeedback in patients with swallowing disorders.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2021)
Article
Medicine, Research & Experimental
Mohammed F. Safi, Sandra Martin, Lincoln Gray, Christy L. Ludlow
Summary: Transcutaneous stimulation above and below the hyoid has different effects on hyolaryngeal movement during swallowing, with submental stimulation reducing anterior hyoid motion and increasing hyoid elevation in healthy volunteers. This indicates that participants have an internal schema for swallowing movement patterning with feedforward correction for the effects of stimulation.
Article
Otorhinolaryngology
Linda M. Rowe, Nadine P. Connor, John A. Russell
Summary: This study assessed the effect of CRT on respiratory-swallow coordination using a rat model and found that CRT rats had significantly increased postswallow inhale events. The findings suggest that the rat CRT model is valid for studying respiratory-swallow coordination in HNC patients undergoing CRT.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Physiology
Naohito Hao, Anna Sasa, Sirima Kulvanich, Yuta Nakajima, Kouta Nagoya, Jin Magara, Takanori Tsujimura, Makoto Inoue
Summary: This study examined the coordination of respiration and swallowing in healthy humans through various experiments. It was found that the major coordination pattern of respiration and swallowing was expiration-swallow-expiration (EE type) during voluntary swallowing and chewing. Understanding the mechanisms underlying respiration and swallowing is crucial for evaluating how coordination affects physiological swallowing in dysphagic patients.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Suzanne N. King, Evan Greenwell, Nada Kaissieh, Lekha Devara, Zachary Carter, James Fox, Megan Blackburn
Summary: Swallowing impairments are a major complication of radiation treatment for oropharyngeal cancers, affecting oral intake and quality of life. The timing and functional consequences of radiation treatment on the swallowing process are not well understood. Using a rodent radiation injury model, this study found that tongue dysfunction is one of the first feeding problems to occur immediately after radiation treatment to the submental muscles.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nerea Molina-Hernandez, Jose Lopez Chicharro, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, David Rodriguez-Sanz, Davinia Vicente-Campos, Daniel Marugan-Rubio, Samuel Eloy Gutierrez-Torre, Cesar Calvo-Lobo
Summary: The study aimed to evaluate the reliability and repeatability of using a thoracic orthosis for simultaneous thickness measurements of both hemi-diaphragms during normal breathing. The results showed good reliability and repeatability of the measurements using the thoracic orthosis, indicating its potential for hemi-diaphragm breathing re-education.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Pediatrics
Christie L. Glau, Elaina E. Lin, Thomas W. Conlon, Adam S. Himebauch, Garrett P. Keim, Akira Nishisaki
Summary: This study aimed to investigate the thickness and contractility values of the diaphragm in children. It found that the diaphragm thickness and contractility were similar across different age groups, but the excursion and strain varied. During mechanical ventilation, all measures of diaphragm contractility were diminished.
PEDIATRIC PULMONOLOGY
(2023)
Article
Engineering, Biomedical
Annemijn H. Jonkman, Ricardo Juffermans, Jonne Doorduin, Leo M. A. Heunks, Jaap Harlaar
Summary: The accuracy of EMGdi parameters in critically ill ICU patients can be compromised by ECG interference in the signal. A new Estimated ECG Subtraction (EES) method was designed to address this issue and was found to be more effective than using a wavelet-based adaptive filter alone, potentially improving diaphragm activity monitoring and control in clinical practice.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Neurosciences
Elisa J. Gonzalez-Rothi, Kun-Ze Lee
Summary: Acute intermittent hypoxia has shown promise as a treatment for respiratory insufficiency in individuals with spinal cord injury, through inducing neuroplasticity and functional recovery. Research in animal models has laid the foundation for the translation of this therapeutic strategy to clinical populations.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Fabio Squarcio, Timna Hitrec, Marco Luppi, Davide Martelli, Alessandra Occhinegro, Emiliana Piscitiello, Ludovico Taddei, Domenico Tupone, Roberto Amici, Matteo Cerri
Summary: Rats emit a distress call of 22-kHz ultrasonic vocalisation to warn their group of danger. Surprisingly, this study found that rats can emit these vocalisations during REM sleep, but not during non-REM sleep. The emission occurs during the expiratory phase and can happen singularly or as a train. This is the first report to demonstrate rats vocalising during REM sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Geriatrics & Gerontology
Susumu Sato, Shinjiro Miyazaki, Akira Tamaki, Yoshihiro Yoshimura, Hidenori Arai, Dai Fujiwara, Hideki Katsura, Atsuyoshi Kawagoshi, Ryo Kozu, Keisuke Maeda, Sumito Ogawa, Jun Ueki, Hidetaka Wakabayashi
Summary: Respiratory sarcopenia, characterized by respiratory muscle weakness and decreased respiratory muscle mass, is an important condition that has not been adequately evaluated in clinical practice. This position paper provides an overview of the basic knowledge, diagnostic and assessment methods, mechanisms, involvement in respiratory diseases, intervention and treatment methods, and future perspectives on respiratory sarcopenia. The consensus on respiratory sarcopenia is also summarized, with recommendations for evaluating respiratory muscle strength and mass. Further research is needed to establish cutoff values for defining decreased respiratory muscle mass.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Otorhinolaryngology
Karen B. Ng, Esther Guiu Hernandez, Kerstin L. C. Erfmann, Richard D. Jones, Phoebe Macrae, Maggie-Lee Huckabee
Summary: The study aimed to compare muscle activity during swallowing with different levels of effort. Results showed that maximum effort swallowing increased muscle activity, while minimum effort swallowing decreased muscle activity.
Article
Critical Care Medicine
Sabhya Rana, Michael D. Sunshine, John J. Greer, David D. Fuller
Summary: Respiratory compromise after cervical spinal cord injury is a major cause of mortality and morbidity. Ampakines, which are allosteric modulators of AMPA receptors, can increase diaphragm electromyography activity and aid in respiratory rehabilitation.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Neurosciences
Margo Randelman, Lyandysha V. Zholudeva, Stephane Vinit, Michael A. Lane
Summary: This article reviews the anatomical incompleteness and neuroplasticity resulting from spinal cord injuries, as well as how non-invasive respiratory treatments can enhance recovery. It focuses on current clinically used respiratory training strategies and those in development, while also considering the impact of training on non-respiratory networks. Insights are given on advances in pre-clinical and translational research in this area, with a look into future directions for enhancing plasticity and improving functional outcomes after SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Muge Molbay, Eylem Ozaydin-Goksu, Dijle Kipmen-Korgun, Ali Unal, Murat Ozekinci, Erhan Cebeci, Emin Maltepe, Emin Turkay Korgun
Summary: This study demonstrates that human trophoblast progenitor cells (hTPCs) induced to differentiate along neural lineages enhance the expression of angiogenic and neurogenic factors in the rat brain after stroke. The transplantation of hTPCs could potentially provide a novel therapeutic approach for the treatment of stroke.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Nursing
Simge Kalav, Hicran Bektas, Ali Unal
Summary: Interventions based on the Chronic Care Model can increase patient satisfaction and raise awareness of the risk of secondary stroke. However, the intervention showed no significant effects on primary outcomes such as self-efficacy and quality of life for patients with ischemic stroke.
JAPAN JOURNAL OF NURSING SCIENCE
(2022)
Article
Anesthesiology
Ali Unal, Ethem Murat Arsava, Gulsen Caglar, Mehmet Akif Topcuoglu
Summary: The contemporary monitoring practice in critical care settings relies on alarm systems with high sensitivity but low specificity, resulting in a large number of alarms that mainly originate from ECG and pulse oximeters in NCCUs. Some types of alarms, such as those from ventilators, decrease during morning shifts.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Clinical Neurology
Liedewei Van de Vondel, Jonathan De Winter, Danique Beijer, Giulia Coarelli, Melanie Wayand, Robin Palvadeau, Martje G. Pauly, Katrin Klein, Maren Rautenberg, Lena Guillot-Noel, Tine Deconinck, Atay Vural, Sibel Ertan, Okan Dogu, Hilmi Uysal, Vesna Brankovic, Rebecca Herzog, Alexis Brice, Alexandra Durr, Stephan Klebe, Friedrich Stock, Almut Turid Bischoff, Tim W. Rattay, Maria-Jesus Sobrido, Giovanna De Michele, Peter De Jonghe, Thomas Klopstock, Katja Lohmann, Ginevra Zanni, Filippo M. Santorelli, Vincent Timmerman, Tobias B. Haack, Stephan Zuchner, Rebecca Schuele, Giovanni Stevanin, Matthis Synofzik, A. Nazli Basak, Jonathan Baets
Summary: This study identifies the association between SPTAN1 gene and neurological disorders such as ataxia and spastic paraplegia. Through screening a large number of datasets and protein modeling, multiple SPTAN1 variants are identified, and disrupted interlinking of spectrin helices is suggested as a key feature of the pathomechanism.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Nora Hertel, Magdalena Kuzma-Kozakiewicz, Marta Gromicho, Julian Grosskreutz, Mamede de Carvalho, Hilmi Uysal, Reinhard Dengler, Susanne Petri, Sonja Koerner
Summary: This study aimed to investigate the correlations between routine blood parameters and disease severity, progression rate, and survival in ALS patients. The results suggest that CK, ALB, CREA, and HDL may serve as potential markers for disease severity or progression, and may provide insights into ALS pathogenesis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Catarina Falcao de Campos, Marta Gromicho, Hilmi Uysal, Julian Grosskreutz, Magdalena Kuzma-Kozakiewicz, Miguel Oliveira Santos, Susana Pinto, Susanne Petri, Michael Swash, Mamede de Carvalho
Summary: This study analyzed the diagnostic pathway of ALS patients from different countries to identify the major challenges. The results showed that early diagnosis of ALS is difficult, but patients who were evaluated by a neurologist earlier and underwent electromyography had a higher probability of being diagnosed with ALS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Ana Rita Henriques, Marta Gromicho, Julian Grosskreutz, Magdalena Kuzma-Kozakiewicz, Susanne Petri, Hilmi Uysal, Susana Pinto, Marilia Antunes, Mamede De Carvalho, Ruy M. Ribeiro
Summary: A study found that the practice of contact sports, especially those associated with high-intensity physical activity and repetitive injuries to the cervical spine and head, may increase the risk of amyotrophic lateral sclerosis (ALS). The study analyzed 2247 individuals from European countries and discovered that those who participated in contact sports had a 76% higher chance of being diagnosed with ALS. Age, smoking status, and tobacco exposure were also identified as risk factors for ALS.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Mustafa Coban, Ugur Bilge, Hale Balseven, Hilmi Uysal, Betul Artut
Summary: The study aims to analyze the quality of economic evaluation studies for ALS. The Consensus on Health Economic Criteria (CHEC)-list was used to assess the studies. It was found that the studies mainly focused on medical costs and neglected social care costs. Although most studies scored high in terms of purpose and research question, some scored low in ethical dimension, comprehensiveness of expenditure items, sensitivity analyses, and study design. The recommendations include addressing the low-scoring checklist items and considering social care costs in future cost evaluation studies for ALS and other chronic diseases.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Asef Azad, Ummu Rana Gokmen, Hilmi Uysal, Sadi Koksoy, Ugur Bilge, Ayse Esra Manguoglu
Summary: Excessive autophagy levels in FoxP3(+) Tregs in ALS patients may contribute to increased cell death and worsened neuroinflammation and disease onset, although disease progression is not directly attributable to autophagy levels in FoxP3(+) Tregs.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Meeting Abstract
Clinical Neurology
Azize Yasemin Goksu Erol, Fatma Gonca Kocanci, Devrim Demir-Dora, Hilmi Uysal
Meeting Abstract
Clinical Neurology
Cansu Aydin Kaya, Abir Alaamel, Hilmi Uysal
Letter
Neurosciences
Abir Alaamel, Rifat Sahin, Merve Hashan, Tutku Taskinoglu, Tugba Ozel, Nazan Simsek Erdem, Hilmi Uysal
Summary: This article presents a case of acute inflammatory demyelinating polyneuropathy with facial onset after SARS-CoV-2 infection. The patient exhibited facial diplegia followed by bilateral ascendance paralysis, indicating possible neurological involvement due to viral infection.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Tugba Ozel, Nazan Simsek Erdem, Ali Unal, Ata Nevzat Yalcin, Dilara Inan, Nevruz Ilhanli, Hilmi Uysal
Summary: The study aimed to analyze the neurological manifestations in hospitalized COVID-19 patients and determine the association with mortality. The results showed that neurological symptoms were frequent in COVID-19 patients and could occur in the early or late stages of the disease, but they were not correlated with mortality.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Ferda Ilgen Uslu, Hilmi Uysal
Summary: Transient ischemic attack (TIA) of spinal cord (SC) is a rare condition characterized by sudden paralysis, sensory loss, and back pain. A case report of a patient with acute painful paraplegia is presented, with symptoms resolving within a few hours. Literature review identified a total of 10 patients, mostly male with a mean age of 53.8. Paraparesis/plegia was present in all cases, with radicular pain in most. Hypertension, smoking, and diabetes mellitus were common vascular risk factors. TIA duration ranged from 1 minute to 24 hours, and the most common etiology was aortic dissection.
AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY
(2022)
