Article
Electrochemistry
Azam Zolfaghari Asl, Amir Abbas Rafati, Sadegh Khazalpour
Summary: An electrochemical sensor based on a titanium dioxide and multi-walled carbon nanocomposite was fabricated for the simultaneous detection of guanine and adenine. The sensor exhibited high sensitivity, good reproducibility, long-term stability, and could successfully measure guanine and adenine in diluted human serum samples.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Ayesha Kousar, Ishan Pande, Laura F. Pascual, Emilia Peltola, Jani Sainio, Tomi Laurila
Summary: One of the major challenges in measuring dopamine (DA) using electro-chemical methods in living organisms is to achieve selectivity in the presence of interfering substances like ascorbic acid (AA) and uric acid (UA). Researchers have used complicated multimaterial structures and ill-defined pretreatments to enhance selectivity. However, the lack of control over the electrode structures has made it difficult to establish a relationship between selectivity and structure. Carbon nanofiber (CNF) electrodes have shown promise in neurobiological applications due to their easily customizable structure. In this study, the sensitivity and selectivity of CNF electrodes towards DA were controlled by adjusting the lengths of the CNF during the fabrication process while maintaining similar surface chemistries. It was found that increasing the fiber length enhanced the sensitivity towards DA while also causing a shift in the oxidation peaks of AA and DA, leading to excellent selectivity.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Emad A. Khudaish, Adhara Al-Badri
Summary: Functionalized carbon nanotubes with excess oxygen-containing functional groups were prepared using a modified Hummers method, showing exceptional electrochemical activity for norepinephrine detection in serum blood samples with a low detection limit. The sensor exhibited good selectivity and recovery rates.
Article
Chemistry, Analytical
Aysu Arman, Sener Saglam, Aysem Uzer, Resat Apak
Summary: The study presented a sensitive detection method for nitroaromatic explosives using a GC/MWCNTs/PEI electrode coated with gold nanoparticles. The method successfully detected TNT, DNT, 2,4-DNP, PA, and tetryl in a linear range, with detection limits ranging from 15 μg L-1 to 135 μg L-1. This method was also validated against the reference LC-MS method for analyzing explosives in soil samples.
Article
Electrochemistry
Sonia Sam, Manna Rachel Mathew, K. Girish Kumar
Summary: This article presents the development of a simple electropolymer-based voltammetric sensor for the sensitive determination of melanoma biomarkers, L-Dopa, and L-Tyrosine. The modified glassy carbon electrode exhibits excellent electro-catalytic properties for the oxidation of the analytes, enabling their simultaneous determination. The sensor shows consistent performance in terms of fabrication, characterization, calibration, and real sample applicability, and the spike recovery analysis confirms its practical application in real sample analysis.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Cheng-Hui Shen, Yu-Na Chang, You-Liang Chen, Chung-Wei Kung
Summary: A highly porous and chemically stable metal-organic framework (MOF) with enriched sulfonate groups, SO3-MOF-808, is synthesized and proposed as a porous alternative to Nafion for modulating the selectivity of electrochemical reactions. The use of SO3-MOF-808 thin film as an electrode coating significantly improves the current signal for dopamine oxidation and the selectivity against interfering compounds.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Ishfaq Ahmad Rather, Feroz Ahmad Sofi, Mohsin Ahmad Bhat, Rashid Ali
Summary: A facile method to obtain a new one-walled mesa-substituted phenylboronic acid-functionalized calix[4]pyrrole (C4P) has been demonstrated, and its excellent sensitivity and stability in electrochemical sensing of dopamine (DA) have been confirmed.
Article
Biochemical Research Methods
Reza Abbasi, Juanjuan Liu, Sorina Suarasan, Sebastian Wachsmann-Hogiu
Summary: Biosensors have great potential in detecting analytes of interest at the point-of-need. Integration of microfluidic and chemiluminescence systems on a single chip allows for simplified sample handling and data collection, making it suitable for applications in medical diagnosis.
Article
Electrochemistry
Gan Zhu, Yaqi Zhang, Yunhang Liu, Meimei Guo, Mingming Zhang, Tingting Wu, Yongfeng Li, Hongyuan Zhao
Summary: In this study, a modified glassy carbon electrode (GCE) sensor was developed using a nanocomposite material composed of graphitized and carboxylated multi-walled carbon nanotubes (GR-MWCNTs-COOH) and zirconia (ZrO2) nanoparticles. The sensor exhibited excellent electrochemical sensing performance for the determination of methyl parathion (MP) due to the synergistic effect of GR-MWCNTs-COOH and ZrO2.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Chemistry, Physical
Prottasha Kairy, Md Mosaraf Hossain, M. Azizur R. Khan, Albandary Almahri, Mohammed M. Rahman, Mohammad A. Hasnat
Summary: In this study, a pristine glassy carbon electrode (GCE) was electrochemically activated and used for efficient oxidation of ascorbic acid (AA). The GCE surface was characterized before and after functionalization using electrochemical and X-ray photoelectron spectroscopy (XPS). The oxidized GCE exhibited better electrochemical performance in an alkaline medium and followed 1st order and diffusion-controlled kinetics. The proposed oxidized GCE shows potential for use as an anode in AA fuel cells.
SURFACES AND INTERFACES
(2022)
Article
Electrochemistry
Mohammad A. Hasnat, Munira Siddika, S. M. Nizam Uddin, Khalid A. Alamry, Mohammed M. Rahman
Summary: An efficient electrocatalyst for the direct oxidation of ascorbic acid was developed and implemented on an IrOx immobilized glassy carbon electrode. The GC-IrOx electrode showed excellent oxidation performance and good stability, indicating its potential application as an anode in ascorbic acid fuel cells.
ELECTROCHIMICA ACTA
(2021)
Article
Electrochemistry
Gan Zhu, Qian Wang, Yunhang Liu, Meimei Guo, Runqiang Liu, Hongyuan Zhao
Summary: In this study, graphitized and carboxylated multi-walled carbon nanotubes (GCMCNTs) were used to modify the glass carbon electrode (GCE) to construct the GCMCNTs/GCE sensor for GA detection. The GCMCNTs, with one-dimensional nanotube-like structure, exhibited high specific surface area and excellent electrical conductivity. The GCMCNTs with high graphitization degree and carboxylation groups provided more microsites for electrochemical reaction and efficient electron transport channels, enhancing electron transmission and carbon material dispersibility. The GCMCNTs/GCE sensor achieved sensitive electrochemical determination of GA, with a low limit of detection of 0.0032 mu M (S/N=3) and a linear equation of I-p (mu A) =21.506C+3.134 (R-2 =0.995) in the linear GA concentration range of 0.01-10 mu M. Moreover, the sensor showed good GA detection performance in tap water samples.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Chemistry, Analytical
Liying Zhang, Chuanrui Zhao, Yujiao Bai, Qian Wang, Pan Ma, Xiaojie Ma, Peihua Zhu
Summary: This study successfully prepared an environmentally-friendly luminophore ZnBCBTP@MWCNTs, and constructed a label-free electrochemiluminescence biosensor based on it for ultra-sensitive detection of uric acid. The sensor exhibited a good linear relationship, low detection limit, and good selectivity, stability, and repeatability in clinical bioanalysis.
Article
Electrochemistry
Qingbo Du, Xiulun Sun, Changlei Song, Yingchun Fang, Xiaoxue Xie, Yu-e Duan, Na Zhang
Summary: In this study, an electrochemical ascorbic acid (AA) sensor was successfully fabricated using a composite film modified electrode. The sensor exhibited excellent electrocatalytic ability towards the oxidation of AA and achieved satisfactory results in the detection of AA in water samples, demonstrating high selectivity and stability.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2023)
Article
Chemistry, Analytical
Shuang-Ning Li, Ya You, Bo Liu, Xin-Yu Jiang, Jin-Gang Yu
Summary: A novel nanocomposite material, with intertwined ferric vanadate and multi-walled carbon nanotubes (FeV/MWCNTs), has been drop-coated onto a glassy carbon electrode. This constructed sensor shows improved conductivity, larger effective surface area, and better electrocatalytic activity for the sensitive determination of uric acid in biological fluids.
Article
Chemistry, Analytical
Viktoriia D. Luzanova, Nina B. Rozhmanova, Yuri V. Volgin, Pavel N. Nesterenko
Summary: A HPLC method using a faujasite-packed column and methanol as eluent was developed for direct determination of water impurities in various organic solvents. Water peaks were detected by refractometry or indirect spectrophotometry at 204 nm. The method achieved a LOD and LOQ of 0.001 wt% and 0.0033 wt% respectively for a 20 μL sample volume and obtained a linear calibration plot (R2 = 0.9998) for water content between 0.01 and 9.55 wt%. The method was successfully applied to the analysis of polar organic solvents including acetonitrile, nitromethane, 1,4-dioxane, 2-ethoxyethanol, methanol, dimethyl sulfoxide (DMSO), ethanol and 2-propanol.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Nikita Sarvin, Ruslan Puzankov, Georgii Vasiyarov, Pavel N. Nesterenko, Sergey M. Staroverov
Summary: Macrocyclic glycopeptide antibiotics immobilized on silica are effective stationary phases for chiral recognition and HPLC separation. The enantioselectivity depends on the ligand structure, immobilization chemistry, and separation conditions. In this study, three new chiral stationary phases based on eremomycin were prepared and investigated for enantioseparation of amino acids. The chloreremomycin-based stationary phase demonstrated the most successful chiral recognition, and efficient enantioselective separation of amino acids was achieved using pure water as the eluent.
Article
Chemistry, Analytical
Lewellwyn J. Coates, Andrew Gooley, Shing Chung Lam, Boyjie Firme, Paul R. Haddad, Hans-Jurgen Wirth, Angel Diaz, Frank Riley, Brett Paull
Summary: Due to their size, conventional high performance liquid chromatographs (HPLCs) are difficult to place close to a reaction vessel within a pharmaceutical manufacturing or development site. However, a compact and modular separation system using capillary HPLC has been developed to enable co-location of an HPLC with a small-scale reactor for reaction monitoring. The compact system showed equivalent quantitative performance to an Agilent 1290 Infinity II HPLC system.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Maria Zorina, Victor V. Dotsenko, Pavel N. Nesterenko, Azamat Temerdashev, Ekaterina Dmitrieva, Yu-Qi Feng, Sanka N. Atapattu
Summary: In this study, phthalylglycyl chloride was proposed as a derivatization agent for the determination of octopamine, adrenaline, and dopamine in urine for the first time. The derivatization process combined reversed-phase liquid chromatography with positive electrospray ionization-high-resolution mass spectrometry. An LC-HRMS method with quantification limits of 5 ng/mL and detection limits of 1.5 ng/mL for all analytes was developed. The derivatization with phthalylglycyl chloride at pH 6.5 and 30 degrees C resulted in a 95-97% yield of derivatives. The proposed method was successfully applied to the analysis of human urine samples and compared with conventional derivatization procedures using 9-fluorenyl-methoxycarbonyl chloride and dansyl chloride.
Article
Chemistry, Multidisciplinary
Liang Wu, Arushi Manchanda, Vipul Gupta, Brett Paull
Summary: A novel thread-based electrofluidic analytical method incorporating isotachophoresis (ITP) and graphene oxide (GO) surfacefunctionalized zones on nylon threads was developed for DNA hybridization. The method demonstrated quantitative trapping and visualization of hybridized DNA bands, allowing potential applications in point-of-care (POC) diagnostic devices.
Article
Chemistry, Analytical
Samia Alsefri, Thanih Balbaied, Hanan Alatawi, Ibtihaj Albalawi, Anna Hogan, Eric Moore
Summary: PCBs have been detected in soil due to industrial pollution in the past two decades, despite being banned. Therefore, it is crucial to develop an analytical method to identify and monitor the sources of PCBs. This study presents a gas chromatography with mass spectrometry technique using the QuEChERS method to effectively extract and detect PCBs in soil samples. The method was found to be simple, sensitive, efficient, and environmentally friendly.
Article
Biochemical Research Methods
Ibraam E. Mikhail, Mohamed Hemida, Leo Lebanov, Snezhana Astrakhantseva, Vipul Gupta, Philip Hortin, John S. Parry, Mirek Macka, Brett Paull
Summary: A novel approach for multi-wavelength ultraviolet absorbance detection using a single board computer and a field programmable gate array is introduced. The method shows excellent linearity and can simultaneously determine multiple compounds in pharmaceutical analysis.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Review
Chemistry, Analytical
Mohamed Hemida, Alireza Ghiasvand, Mirek Macka, Vipul Gupta, Paul R. Haddad, Brett Paull
Summary: Liquid chromatography is a widely used analytical technique in separation science and chemical analysis, and there has been an increasing interest in miniaturizing this technique in recent years. This has been made possible by the development of new miniature and portable detection technologies, allowing for on-site and portable analyses. Significant advancements have been made in the miniaturization of liquid chromatography with photometric, electrochemical, and mass spectrometric detection, leading to the development of field-deployable and portable instruments for various applications. This review provides an overview of recent developments in the miniaturization of detection systems for portable liquid chromatographic systems, along with critical comments and expected future trends.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Oleg Rodinkov, Victor Postnov, Valery Spivakovskyi, Ekaterina Znamenskaya, Anastasia Zheludovskaya, Pavel Nesterenko
Summary: A new scheme for rapid preconcentration and determination of volatile organic substances in air using flame ionization detector is proposed. The scheme involves changing the geometry of the adsorbent layer from adsorption to thermal desorption and utilizes novel magnetic adsorbents. This scheme significantly reduces the preconcentration time and improves the efficiency of analyte determination.
Article
Education & Educational Research
Elaine Stratford, Phillipa Watson, Brett Paull
Summary: This paper presents a research study conducted in an Australian university, exploring the challenges and expectations of early career academics. The findings highlight the need for stronger support and focus on career development within the organizational and sectoral contexts.
Article
Chemistry, Analytical
Harrison Stevens, Estrella Sanz Rodriguez, Brett Paull, Andrew R. Bowie, Zanna Chase, Leon A. Barmuta, Bernadette C. Proemse
Summary: This study presents a simple extraction method for the rapid and selective determination of monosaccharide anhydrides (MAs) concentrations in sediments. MAs detection was performed using ion chromatography with tandem mass spectrometry. The method showed good analytical performance with LODs of 0.10, 0.12, and 0.50 mu g L-1 for LEV, MAN, and GAL, respectively. The developed method was validated using reference materials and successfully applied to quantify MAs in lake sediment samples, allowing the reconstruction of recent fire events.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Arushi Manchanda, Vipul Gupta, Liang Wu, Brett Paull
Summary: A new method and platform based on thread-based electrofluidics has been developed for direct transfer, electrophoretic separation, and pre-concentration of swabbed samples. The physicochemical interactions between the analyte, swab, and thread were studied to understand their effect on transfer efficiency. This method has been successfully applied to transfer, separate, and pre-concentrate DNA from blood, as well as directly analyze dried blood samples.
Article
Chemistry, Analytical
Jawairia Umar Khan, Mirbaz Ali Pathan, Sepidar Sayyar, Brett Paull, Peter C. C. Innis
Summary: Electrophoresis on textile fiber substrates allows for the movement, separation, and concentration of charged analytes. Researchers have developed an approach to optimize the experimental conditions affecting the electrophoretic separation on textile-based substrates. By adjusting the electric field magnitude, sample concentration, and sample volume, efficient separation can be achieved without compromising the analysis time on simple and low-cost textile substrates.
ANALYTICAL METHODS
(2023)
Review
Chemistry, Analytical
Vahid Jalili, Abdullah Barkhordari, Brett Paull, Alireza Ghiasvand
Summary: PFAS are a group of fluorocarbon compounds with wide-ranging applications, but their persistence and toxic properties make them a concern in the environment. Their strong C-F bonds make it difficult for chemical or biological mechanisms to break them down. Therefore, sensitive and selective analytical methods are needed to detect and trace PFAS in biological and environmental matrices.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Liang Chen, Alireza Ghiasvand, Estrella Sanz Rodriguez, Peter C. Innis, Brett Paull
Summary: This research introduces a nanomaterial-assisted thread-based isotachophoresis setup for the clean-up, preconcentration, and trapping of alkaloids in biological fluids, followed by their determination using on-thread desorption electrospray ionization mass spectrometry. The method increases the sensitivity of model solutes up to 10-fold compared to direct DESI-MS analysis, demonstrating the potential of nanomaterial-modified threads in electrofluidic separation and concentration procedures. This innovative approach presents a promising avenue for further exploration in the field of thread-based electrofluidic separation coupled with ambient ionization MS.
