Article
Plant Sciences
Wenshuai Wang, Yaohan Zhang, Zhiying Wang, Jianjun Zhang, Le Jia
Summary: This study investigated the protective effects of Ganoderma lucidum polysaccharides (GLP) on high-fat diet-induced hyperlipidemia and explored the underlying mechanism. The results showed that GLP decreased body weight gain, reduced lipid levels, alleviated tissue injury, and improved oxidative stress and inflammation response. GLP also modulated bile acids synthesis, lipid regulatory factors, and promoted reverse cholesterol transport.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
M. A. Oke, F. J. Afolabi, O. O. Oyeleke, T. A. Kilani, A. R. Adeosun, A. A. Olanbiwoninu, E. A. Adebayo
Summary: Ganoderma lucidum, also known as Lingzhi, is a medicinal mushroom used in traditional medicine for various health benefits. It contains a wide range of bioactive compounds, including triterpenoids and polysaccharides, which have been shown to possess numerous pharmacological activities. Studies have demonstrated the potential of Ganoderma lucidum in disease prevention and treatment, leading to the development of various formulations and products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Shaodan Chen, Xiaoying Guan, Tianqiao Yong, Xiong Gao, Chun Xiao, Yizhen Xie, Diling Chen, Huiping Hu, Qingping Wu
Summary: In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have a protective effect on liver damage caused by restraint stress in mice by improving oxidative status. Two polysaccharides, including a neutral beta-glucan (GLPB2) and an acidic beta-glucan (GLPC2), were purified from GLP. GLPC2 exhibited a stronger hepatoprotective effect compared to GLPB2. The findings provide a theoretical basis for the potential application of G. lucidum polysaccharides as hepatoprotective agents in the food and pharmaceutical industry.
Article
Biochemistry & Molecular Biology
Jiaqi Jiao, Tianqiao Yong, Longhua Huang, Shaodan Chen, Chun Xiao, Qingping Wu, Huiping Hu, Yizhen Xie, Xiangmin Li, Yuancao Liu, Manjun Cai, Ruifang Zhang, Ting Xie, Rongjie Liu
Summary: In this paper, we revealed the hypoglycemic effect of Ganoderma lucidium polysaccharide F31, which showed efficacies between 45 and 54%, approaching that of liraglutide (52%). F31 reduced body weight gains and food intakes, protected kidney function, promoted apoptosis in epididymal fat, and induced early apoptosis in 3 T3-L1 preadipocyte cells. Molecular docking showed a possible cross-talk between kidney and epididymal fat through the glycerophosphorylcholine-Bax axis. Overall, F31 alleviated hyperglycemia through kidney protection and adipocyte apoptosis in db/db mice, providing novel insights into the hypoglycemic activity of polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Fang Kou, Yunfei Ge, Weihao Wang, Yuxia Mei, Longkui Cao, Xuetuan Wei, Hang Xiao, Xian Wu
Summary: Ganoderma lucidum polysaccharides have unique functional properties and various processing technologies have been used to improve their yield and utilization. This review summarizes the structure and health benefits of G. lucidum polysaccharides, and discusses factors that may affect their quality, including chemical modifications. These modifications improve the physicochemical characteristics and utilization of G. lucidum polysaccharides, making them more stable and suitable for encapsulating active substances. Ultimately, G. lucidum polysaccharide-based nanoparticles are designed to deliver functional ingredients for better health-promoting effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Zhiyuan Chen, Guozhi Xiao
Summary: The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 from Ganoderma lucidum, which possess immune-enhancing activities, were prepared using a one-pot glycan assembly strategy that features orthogonal one-pot glycosylation, one-pot assembly of oligosaccharides, and modular and convergent [4+5+5] assembly of the highly branched tetradecasaccharide.
Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Ming Cai, Hua Mu, Haoyong Xing, Zhenhao Li, Jing Xu, Wei Liu, Kai Yang, Peilong Sun
Summary: The study found that Ganoderma lucidum spores with the sporoderm removed showed stronger metabolic promotion effects and better anti-inflammatory properties after in vitro digestion.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Ming Cai, Haoyong Xing, Baoming Tian, Jing Xu, Zhenhao Li, Hua Zhu, Kai Yang, Peilong Sun
Summary: The study revealed that Ganoderma lucidum polysaccharides can extend swimming time, enhance endurance, and promote fatigue recovery, especially polysaccharides with molecular weights above 10 kDa. These GLPs may reduce the activities of SUN and CK, decrease the levels of MDA and BLA, increase the level of Gly, accelerate fat transformation, and improve the activities of GPx, SOD, and LDH in all treated mice. Therefore, GLPs above 10 kDa could be potential agents with antifatigue activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Chung-Hsiung Huang, Tzu-Yu Chen, Guo-Jane Tsai
Summary: This study investigated the hypouricemic effects of submerged culture of Ganoderma lucidum. The results demonstrated the stronger hypouricemic effect of the submerged culture's mycelium, as well as the effectiveness of the extracellular polysaccharides in improving renal and hepatic function.
Article
Biochemistry & Molecular Biology
Loreto Robles-Hernandez, Nora A. Salas-Salazar, Ana C. Gonzalez-Franco
Summary: This study aimed to purify and characterize the antibacterial activity against plant pathogenic bacteria from culture fluids of Ganoderma lucidum, revealing that the bioactive compounds are small polysaccharides. This is the first report of such polysaccharides produced by G. lucidum with activity against bacterial plant pathogens.
Review
Biochemistry & Molecular Biology
Emin Cadar, Ticuta Negreanu-Pirjol, Carolina Pascale, Rodica Sirbu, Irina Prasacu, Bogdan-Stefan Negreanu-Pirjol, Cezar Laurentiu Tomescu, Ana-Maria Ionescu
Summary: This review examines the scientific research on the natural bioactive compounds found in extracts of Ganoderma lucidum (G. lucidum) and their potential in cancer treatment. The study reveals that G. lucidum contains important bioactive compounds such as polysaccharides, triterpenoids, and sterols, which have demonstrated multiple anticancer effects including immunomodulatory, anti-proliferative, cytotoxic, and antioxidant actions. However, there is still uncertainty about the effects of G. lucidum bioactive compounds in treating different types of cancer, and further clinical trials are needed to clarify their potential benefits in cancer prevention and treatment.
Article
Nutrition & Dietetics
Guo Liu, Jun Zhang, Qixin Kan, Mingyue Song, Tao Hou, Siyu An, Hongyu Lin, Hongzhang Chen, Liuyun Hu, Jie Xiao, Yunjiao Chen, Yong Cao
Summary: Ganoderma lucidum polysaccharides (GLP) have excellent immunomodulatory activity. Among them, the high molecular weight Restriction Fragment Length Polymorphism (RGLP) exhibits stronger immunomodulatory activity than the low molecular weight EGLP. Structural analysis reveals that RGLP-1 is a β-pyran polysaccharide with specific glycosyl bonds, showing potential immunomodulatory properties.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Liyuan Li, Yannan Guo, Qing Huang, Xiaojin Shi, Qingqing Liu, Fang Wang, Qingfei Liu, Kang Yu, Zhao Wang
Summary: The compound GPP, composed of water-soluable Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP), enhances immune function in mice by enhancing macrophage cell function and natural killer (NK) cell activity. GPP also increases the diversity of intestinal microorganisms and has a positive effect on colitis model mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Integrative & Complementary Medicine
Hua Luo, Dechao Tan, Bo Peng, Siyuan Zhang, Chi Teng Vong, Zizhao Yang, Yitao Wang, Zhibin Lin
Summary: Ganoderma lucidum polysaccharides (GLPs) have been extensively studied for their therapeutic effects, but the exact mechanisms and pathways still require further research.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)