期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 23, 期 2, 页码 111-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1773-2247(13)50018-9
关键词
Inulin; Doxorubicin; Drug resistance; Conjugate; Cytotoxicity
资金
- NIH/NCI Center for Oncophysics [CTOPSOCU54-CA-143837]
- National Science Foundation
Chemotherapy is one of the primary treatment mechanisms for treating cancer. Current chemotherapy is systemically delivered and causes significant side effects; therefore the development of new chemotherapeutic agents or enhancing the effectiveness of current chemotherapeutic could prove vital to patients and cancer care. The purpose of this research was to develop a new conjugate composed of doxorubicin (chemotherapeutic) and inulin (polysaccharide chain) and evaluate its potential as a new therapeutic agent for cancer treatment. The synergistic effect of inulin conjugated to doxorubicin has allowed the same cytotoxic response to be maintained or improved at lower doses as compared to doxorubicin. Supporting results include cytotoxicity profiles, calf thymus DNA binding studies. confocal microscopy, and transport studies.
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