期刊
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
卷 30, 期 6, 页码 920-928出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01932690802646264
关键词
Bioavailability; cationic amphiphile; microemulsion; mucin; self-emulsifying drug-delivery system
资金
- Camurus AB
- Foundation for Knowledge and Competence Development in Sweden
The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据