Article
Oncology
Audrey E. Brown, Amy M. Shui, Dieter Adelmann, Neil Mehta, Garrett R. Roll, Ryutaro Hirose, Shareef M. Syed
Summary: This retrospective analysis of 298 HCC patients who underwent liver transplant aimed to understand the impact of the number and type of local regional therapies (LRTs) on peri-operative outcomes. Patients who received more than 3 LRTs before liver transplant had a higher risk of biliary leak but similar outcomes to those with fewer LRTs. The study highlights the need for further evaluation on the effects of multiple rounds of LRTs on transplant outcomes.
Article
Surgery
Matteo Serenari, Jacopo Lenzi, Alessandro Cucchetti, Federica Cipriani, Matteo Donadon, Francesco Ardito, Federico Fazio, Daniele Nicolini, Maurizio Iaria, Simone Famularo, Pasquale Perri, Luca Ansaloni, Matteo Zanello, Quirino Lai, Simone Conci, Sarah Molfino, Cecilia Ferrari, Paola Germani, Mauro Zago, Maurizio Romano, Giuseppe Zimmitti, Adelmo Antonucci, Luca Fumagalli, Albert Troci, Valentina Ferraro, Riccardo Memeo, Michele Crespi, Marco Chiarelli, Giorgio A. Ercolani, Mohamed A. Hilal, Giacomo Zanus, Enrico Pinotti, Paola Tarchi, Guido Griseri, Gian Luca Baiocchi, Andrea Ruzzenente, Massimo Rossi, Elio Jovine, Marcello Maestri, Gian Luca Grazi, Fabrizio Romano, Raffaele Dalla Valle, Matteo Ravaioli, Marco Vivarelli, Alessandro Ferrero, Felice Giuliante, Guido Torzilli, Luca Aldrighetti, Matteo Cescon
Summary: This study aimed to evaluate the impact of a liver transplantation program on the outcomes of resectable hepatocellular carcinoma. The presence of a liver transplantation program was associated with decreased posthepatectomy liver failure rates and increased likelihood of salvage liver transplantation in case of tumor recurrence, which had a positive impact on postoperative survival.
Review
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Mamone, Settimo Caruso, Mariapina Milazzo, Giorgia Porrello, Ambra Di Piazza, Giovanni Gentile, Vincenzo Carollo, Francesca Crino, Gianluca Marrone, Gianvincenzo Sparacia, Luigi Maruzzelli, Roberto Miraglia, Salvatore Gruttadauria
Summary: Liver transplantation provides the best survival benefit for hepatocellular carcinoma (HCC) patients who cannot undergo resection. The Milan criteria have been developed to select suitable candidates for transplantation, aiming to improve survival and reduce the risk of HCC recurrence. However, up to 20% of cases experience HCC recurrence after transplantation, posing a significant challenge due to poor prognosis. Various extended criteria have been proposed to accommodate the increasing demand for organs and the associated higher risk of recurrence. Radiologists need to be aware of the possibility of HCC recurrence involving multiple organs after transplantation. Understanding the location and radiologic appearance of recurrent HCC is crucial for choosing the most appropriate therapy.
INSIGHTS INTO IMAGING
(2023)
Review
Oncology
Daniel A. Butcher, Kelli J. Brandis, Haolu Wang, Liam Spannenburg, Kim R. Bridle, Darrell HG. Crawford, Xiaowen Liang
Summary: The aim of this meta-analysis was to evaluate the effect of pre-liver transplantation transarterial chemoembolisation (TACE) on long-term survival and complications of hepatocellular carcinoma (HCC) patients. The study found that patients treated with TACE had similar outcomes to non-TACE patients, but they had worse prognostic features.
Article
Oncology
Riccardo Pravisani, Federico Mocchegiani, Miriam Isola, Dario Lorenzin, Gian Luigi Adani, Vittorio Cherchi, Maria De Martino, Andrea Risaliti, Quirino Lai, Marco Vivarelli, Umberto Baccarani
Summary: Inflammatory biomarkers have prognostic value in surgically treated HCC patients, while nutritional biomarkers predict outcomes after hepatic resection but not liver transplantation. Nutritional status improves significantly in HCC patients post-liver transplant at 1 year, while inflammatory state tends to persist. Post-liver transplant PLR and NLR maintain prognostic value, while CONUT and PNI acquire it.
Review
Oncology
Filippo Pelizzaro, Martina Gambato, Enrico Gringeri, Alessandro Vitale, Umberto Cillo, Fabio Farinati, Patrizia Burra, Francesco Paolo Russo
Summary: Recurrence of hepatocellular carcinoma after liver transplantation is a major concern, with poor prognosis and uncertainty in management. There is currently lack of specific surveillance strategy and sufficient data to support immunosuppressive drugs and adjuvant therapy.
Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Deok-Gie Kim
Summary: This study investigated the use of antiplatelet drugs in preventing hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). The findings suggest that antiplatelet therapy does not impact HCC recurrence or HCC-specific mortality when used after LT.
Review
Biochemistry & Molecular Biology
Zurabi Lominadze, Kareen Hill, Mohammed Rifat Shaik, Justin P. Canakis, Mohammad Bourmaf, Cyrus Adams-Mardi, Ameer Abutaleb, Lopa Mishra, Kirti Shetty
Summary: The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC), with potential benefits in liver transplantation settings. Immune therapeutic agents have shown promise in down-staging advanced HCCs pre-transplant and managing recurrent HCC post-transplant. This review discusses optimal regimens in the context of liver transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Liangshuo Hu, Zhen Zhao, Fan Mu, Siyi Dong, Chun Zhang, Jianhua Shi, Min Tian, Kun Guo, Xufeng Zhang, Liang Yu, Yi Lv, Bo Wang
Summary: This study aimed to assess the overall survival and disease-free survival of patients with hepatocellular carcinoma (HCC) following liver transplantation (LT) using grafts from deceased donors over 60 years old. The study found that disease-free survival was significantly lower in HCC patients with elderly donors, especially for those with tumors beyond the Milan criteria.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Oncology
Weili Qi, Junlong Dai, Zhancheng Qiu, Youwei Wu, Tianfu Wen, Fei Xie, Fengwei Gao, Yu Zhang, Chuan Li
Summary: We developed a nomogram model for predicting the risk of moderate-to-severe liver surgery-specific complications after hepatectomy in patients with hepatocellular carcinoma (HCC). The model included several predictive factors and showed good clinical value.
Review
Gastroenterology & Hepatology
Sang Jin Kim, Jong Man Kim
Summary: Liver transplantation is an effective treatment for hepatocellular carcinoma, but some patients still experience recurrence after transplantation. Prediction models for HCC recurrence after transplantation have been published, but a standard has not been established. This review summarizes the latest prediction models for HCC recurrence after liver transplantation, focusing on radiologic, serologic, and pathologic factors, and includes studies on living donor and deceased donor transplantation.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Oncology
Mingyang Bao, Qiuyu Zhu, Tuerganaili Aji, Shuyao Wei, Talaiti Tuergan, Xiaoqin Ha, Alimu Tulahong, Xiaoyi Hu, Yueqing Hu
Summary: Surgical treatment remains the best option for patients with hepatocellular carcinoma caused by chronic hepatitis B virus infection, but predicting postoperative complications remains a challenge. Models were developed based on conventional variables to assess the risk of severe complications before and after liver resection. These models could serve as guidelines for surveillance follow-up and post-resection adjuvant therapy design.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Leana Frankul, Catherine Frenette
Summary: Downstaging treatment is crucial for patients with unresectable hepatocellular carcinoma who are not eligible for liver transplantation, but severe organ shortage limits its broader application. Debate over the optimal treatment protocol and assessment method for downstaging treatment is pushing the boundaries of liver transplantation candidate selection.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Oncology
Gil Ho Lee, Hyo Jung Cho, Garam Lee, Han Gyeol Kim, Hee Jung Wang, Bong-Wan Kim, Mi Young Lee, So Young Yoon, Choong-Kyun Noh, Chul Won Seo, Jung Woo Eun, Jae Youn Cheong, Sung Won Cho, Soon Sun Kim
Summary: The study demonstrated that the preoperative edema index using bioelectrical impedance analysis can predict post-hepatectomy complications, especially in patients with liver cirrhosis. Tumor size was identified as the only significant predictive factor for short-term survival after hepatectomy.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)