Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Gi-Ae Kim, Jonggi Choi, Gwang Hyeon Choi, Yun Bin Lee, Dong Hyun Sinn, Young-Suk Lim
Summary: This study aimed to investigate the association between baseline HBV viral load and on-treatment HCC risk in patients with CHB without cirrhosis. The study found that patients with moderate baseline viral load had the highest HCC risk.
Review
Microbiology
Yuanyuan Liu, Vaishnavi Veeraraghavan, Monica Pinkerton, Jianjun Fu, Mark W. Douglas, Jacob George, Thomas Tu
Summary: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with chronic HBV infection being a major risk factor. Current early diagnosis methods have low sensitivity, leading to higher rates of late-stage diagnosis and treatment challenges. Combining viral biomarkers with existing screening methods can improve the accuracy of early diagnosis and patient survival rates.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Marco Y. W. Zaki, Ahmed M. Fathi, Samara Samir, Nardeen Eldafashi, Kerolis Y. William, Maiiada Hassan Nazmy, Moustafa Fathy, Upkar S. Gill, Shishir Shetty
Summary: HBV and HCV infections are the most common risk factors for hepatocellular carcinoma (HCC), and their distribution affects the global prevalence of this type of liver cancer. Hepatitis infections elicit immune responses within the liver microenvironment, and persistent viral infection leads to chronic liver inflammation and carcinogenesis.
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Zelin Tian, Chen Xu, Peijun Yang, Zhibin Lin, Wenlong Wu, Wenjie Zhang, Jian Ding, Rui Ding, Xuan Zhang, Kefeng Dou
Summary: Hepatocellular carcinoma (HCC), caused by viral hepatitis, alcoholic, and non-alcoholic fatty liver disease (NAFLD), is the sixth most common cancer worldwide. Viral hepatitis accounts for 80% of HCC cases globally. NAFLD has become the most common liver disease and major risk factor for HCC in developed countries. This review discusses the specific and similar pathogenesis mechanisms of viral hepatitis-induced HCC and NAFLD-induced HCC, including viral proteins, genetic factors, epigenetic modifications, and abnormal lipid metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Erwan Vo Quang, Yusuke Shimakawa, Pierre Nahon
Summary: Hepatitis B and C are prominent risk factors for hepatocellular carcinoma in different regions, with a goal to eliminate viral hepatitis globally by 2030. Measures like vaccination, antiviral therapies, and liver cancer screening programs are crucial in reducing the burden of HCC worldwide.
LIVER INTERNATIONAL
(2021)
Review
Chemistry, Multidisciplinary
Huimin Kong, Enguo Ju, Ke Yi, Weiguo Xu, Yeh-Hsing Lao, Du Cheng, Qi Zhang, Yu Tao, Mingqiang Li, Jianxun Ding
Summary: Liver disease, particularly viral hepatitis and hepatocellular carcinoma, remains a global healthcare burden with over 2 million deaths per year. The CRISPR/Cas technology shows promise in tackling these diseases at the genetic level. This review focuses on the development of CRISPR editors and the integration of gene editing and nanotheranostics for liver diseases.
Review
Cell Biology
Saleh A. Alqahtani, Massimo Colombo
Summary: Chronic infections with hepatitis B or C virus are common risk factors for hepatocellular carcinoma. Effective antiviral therapies can reduce the risk of developing HCC, but do not eliminate it completely. More strategies are needed to further improve outcomes in preventing HCC in patients with chronic viral hepatitis.
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Cell Biology
Enakshi Sivasudhan, Neil Blake, Zhiliang Lu, Jia Meng, Rong Rong
Summary: This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC, and emphasizes the potential of targeting HBx for novel combinatorial therapies against liver cancer.
Article
Oncology
Yuan-Hung Kuo, Tzu-Hsin Huang, Jing-Houng Wang, Yen-Yang Chen, Ming-Chao Tsai, Yen-Hao Chen, Sheng-Nan Lu, Tsung-Hui Hu, Chien-Hung Chen, Chao-Hung Hung
Summary: This study confirms that while HCV-HCC patients may have a better prognosis when using sorafenib, there is no difference in prognosis between HBV-HCC and HCV-HCC patients when it comes to controlling viral load. The control of viral load is associated with prognosis, while HBV or HCV infection is not.
Review
Gastroenterology & Hepatology
Edina Amponsah-Dacosta
Summary: Eliminating viral hepatitis in sub-Saharan Africa by 2030 is challenging due to the high burden of chronic HBV carriers and the risk of HCC. Increasing coverage of HBV vaccination and improving early diagnosis and care for high-risk individuals is crucial in reducing new cases. Without intervention, HCC incidence and mortality rates in the region are projected to double by 2040, highlighting the urgent need for public health attention.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Microbiology
Toofan Datfar, Michael Doulberis, Apostolis Papaefthymiou, Ian N. Hines, Giulia Manzini
Summary: Viral hepatitis, especially hepatitis B and C, are closely associated with hepatocellular carcinoma development. Different genotypes of hepatitis B virus show varied disease progression, and mutations in viral genomes can predict HCC development. HCV infection leads to hepatocellular lipid accumulation associated with oncogenesis.
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Spiros P. Hiotis, Nuh N. Rahbari, Gerald A. Villanueva, Eunjie Klegar, Wei Luan, Qin Wang, Herman T. Yee
BMC GASTROENTEROLOGY
(2012)
Article
Gastroenterology & Hepatology
Noami Chaudhary, Catherine Lucero, Gerald Villanueva, Michael Poles, Colleen Gillespie, Sondra Zabar, Elizabeth Weinshel
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
Jonathan Cohen, Seth A. Cohen, Kinjal C. Vora, Xiaonan Xue, J. Steven Burdick, Simmy Bank, Edmund J. Bini, Henry Bodenheimer, Maurice Cerulli, Hans Gerdes, David Greenwald, Frank Gress, Irwin Grosman, Robert Hawes, Gerard Mullen, Felice Schnoll-Sussman, Anthony Starpoli, Peter Stevens, Scott Tenner, Gerald Villanueva
GASTROINTESTINAL ENDOSCOPY
(2006)