Article
Cell Biology
Chunyue Hao, Wei Wang, Bin Zhan, Zixia Wang, Jingjing Huang, Ximeng Sun, Xinping Zhu
Summary: The study demonstrates that the Trichinella-derived protein rTsPmy can ameliorate disease progression and reduce inflammatory responses in experimental colitis, by specifically promoting the expansion and differentiation of regulatory T cells in the inflamed colon. These findings provide insights into the immunological mechanisms involved in the therapeutic effect of helminth-derived proteins in inflammatory bowel diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Mobina Jalalvand, Samaneh Enayati, Maryam Akhtari, Elham Madreseh, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi, Aliakbar Amirzargar
Summary: This meta-analysis aimed to determine the frequency of peripheral blood regulatory T cells (Tregs) in inflammatory bowel disease (IBD) patients. The results showed no significant difference in the frequency of PB Tregs between IBD cases and control subjects. However, the frequency of CD4+CD25+CD127- and CD4+CD25+FoxP3+ Tregs were significantly lower in IBD cases. Additionally, UC cases and active IBD cases showed a significantly lower frequency of Treg cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kazuki Sato, Yumi Yamashita-Kanemaru, Fumie Abe, Rikito Murata, Yuho Nakamura-Shinya, Kazumasa Kanemaru, Masafumi Muratani, Andre Veillette, Motohito Goto, Mamoru Ito, Akira Shibuya, Kazuko Shibuya
Summary: DNAM-1 regulates Treg cell function via TIGIT signaling, and can potentially serve as a molecular target for enhancing Treg function in inflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Marcela Laukova, Arielle Glatman Zaretsky
Summary: Foxp3(+) T regulatory cells are essential for suppressing inflammation and maintaining tissue homeostasis. In particular, these cells play a critical role in maintaining the intestinal environment by mediating interactions with the microbiota, supporting barrier integrity, and regulating the immune system. Developing T regulatory cell therapies for intestinal inflammatory diseases, such as inflammatory bowel disease, is of particular interest.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Brody H. Foy, Thoralf M. Sundt, Jonathan C. T. Carlson, Aaron D. Aguirre, John M. Higgins
Summary: The study examines the recovery process of inflammation caused by trauma, ischemia, and infection by tracking the longitudinal dynamics of clinical laboratory measurements in hospitalized patients. The findings reveal a universal recovery trajectory characterized by exponential white blood cell decay and delayed linear growth of platelet count. The co-regulation of white blood cells and platelet dynamics provides a generic approach for identifying high-risk patients and predicting adverse outcomes.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Yijie Song, Man Yuan, Yu Xu, Hongxi Xu
Summary: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders caused by abnormal immune response. The development of proinflammatory cytokine therapeutic agents, including TNF inhibitors, shows promise for treating IBD. Antagonizing other cytokines has shown advantages in clinical trials and can be used to target anti-TNF therapy failure. Additionally, blocking lymphocyte homing helps alleviate inflammation and tissue damage.
Article
Toxicology
J. Chen, J. Jiang, Y. Liu, Y. Ye, Y. Ma, Y. Cen, W. Chen, S. Wang, G. Yang, A. Zhang
Summary: Arsenic disrupts lymphocyte morphology, decreases cell viability, and leads to abnormal proportions of T lymphocyte subsets. By affecting the acetylation levels of histone H4, arsenic may cause dysfunction in regulatory T cells, and histone deacetylase inhibitors may play a role in preventing and treating this immune injury caused by arsenic.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Review
Medicine, General & Internal
Blake O. Langley, Sara E. Guedry, Joshua Z. Goldenberg, Douglas A. Hanes, Jennifer A. Beardsley, Jennifer Joan Ryan
Summary: NLR may have utility for clinical and endoscopic disease activity differentiation and prediction of loss of response to infliximab (IFX). Overall findings suggest NLR may be a promising IBD biomarker. Assessment of NLR is non-invasive, low cost, and widely accessible given NLR is easily calculated from blood count data routinely and serially monitored in patients with IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Zhilin Zhang, Huan Zhang, Tian Chen, Lin Shi, Daorong Wang, Dong Tang
Summary: This article discusses the association between inflammatory bowel disease (IBD) and dysbiosis of the gut microbiota, which leads to persistent immune response and inflammation. Short-chain fatty acids (SCFAs) derived from fiber-rich diet produced by probiotic gut bacteria have shown anti-inflammatory effects and can delay the progression of IBD. The modulation of innate immune recognition and cytokine production by SCFAs may intervene in the progression of IBD. More studies are needed to investigate the clinical impact of SCFA.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Yimeng Yu, Hongyu Bai, Fenglin Wu, Jieqiong Chen, Bin Li, Yangyang Li
Summary: This review focuses on the tissue adaptation of adipose tissue-resident regulatory T cells (AT Treg cells) and their response to various environmental signals. The transcriptional cascades triggered by these signals ultimately establish unique transcriptional modules in adipose tissue Treg cell subsets.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Noriko Goda, Chika Nakashima, Ichiro Nagamine, Sunao Otagaki
Summary: This study explores the immune response of regulatory T cells and its impact on patient prognosis in triple-negative breast cancer (TNBC). The findings show a correlation between high expression of IL-33 and TGFb2 and FOXP3, which serves as a reliable prognostic factor for patients. This discovery provides potential for the development of novel treatment strategies, such as inducing the expression of these cytokines, and enhances our understanding of the role of FOXP3 in regulatory T cells in TNBC.