期刊
JOURNAL OF DIGESTIVE DISEASES
卷 10, 期 3, 页码 181-187出版社
WILEY
DOI: 10.1111/j.1751-2980.2009.00383.x
关键词
Crohn's disease; single nucleotide polymorphism; SLC22A4; SLC22A5
资金
- BIO-X Laboratory of Shanghai Jiaotong University
OBJECTIVE: Recent genomic surveys have identified two single nucleotide polymorphisms (SNP) in SLC22A4 and SLC22A5 as susceptibility loci for Crohn's disease (CD). We conducted the present study to assess whether the two SNP and exon variants in SLC22A4 and SLC22A5 could be implicated in the vulnerability to CD of the Chinese Han population. METHODS: A total of 180 CD patients and 180 healthy controls were studied. Genotyping for the two positive sites and the SNP that we screened from all the exon regions in SLC22A4 and SLC22A5 were typed using the direct sequencing method. RESULTS: Neither individual SNP nor any haplotype was found to be associated with CD in our case-control study. CONCLUSION: In contrast to the Caucasian population, SLC22A4 and SLC22A5 genes are unlikely to play a major role in susceptibility to CD in the Chinese Han population.
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