Article
Immunology
Yangyang Li, Weidong Sun, Quan Wang, Ying Yu, Ying Wan, Kai Zhou, Rong Guo, Xiangan Han, Zhaoguo Chen, Weihuan Fang, Wei Jiang
Summary: This study provides evidence that HutC protein in Vibrio parahaemolyticus plays important roles in bacterial stress response, swimming motility, biofilm formation, cytotoxicity, virulence, and gene regulation.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Garima Arya, Mohinder Pal, Monika Sharma, Bhupinder Singh, Swati Singh, Vishal Agrawal, Rachna Chaba
Summary: This study identified the effector-binding cavity in bacterial sugar acid regulators and demonstrated the similarities in effector-regulator recognition among the FadR subfamily. The research lays the foundation for further investigation into the impact of natural genetic variations on the sensitivity of FadR subfamily regulators to sugar acids and their influence on host-bacterial interactions.
MOLECULAR MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Siqi Zhou, Lian Li, Ming Zhang, Yang Qin, Bo Li
Summary: This article discusses the function and mechanisms of BORIS, particularly in cancer development, as well as the competition between BORIS and CTCF and its impact on chromatin loop formation, which may contribute to cancer progression.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Carlos Henrique Vieira-Vieira, Vita Dauksaite, Anje Sporbert, Michael Gotthardt, Matthias Selbach
Summary: Researchers have developed a quantitative RNA-interactome capture method to assess the function of phosphorylation sites in RNA-binding proteins.
Article
Multidisciplinary Sciences
Maowu Luo, Lei Bao, Yan Chen, Yuanyuan Xue, Yong Wang, Bo Zhang, Chenliang Wang, Chase D. Corley, Jeffrey G. McDonald, Ashwani Kumar, Chao Xing, Yisheng Fang, Erik R. Nelson, Jennifer E. Wang, Yingfei Wang, Weibo Luo
Summary: The histone reader ZMYND8 is selectively expressed in breast cancer stem cells (BCSCs) and promotes breast tumor initiation through its epigenetic functions by regulating 27-HC metabolism, leading to the accumulation of 27-HC in BCSCs and activation of liver X receptor.
Article
Biochemistry & Molecular Biology
Sangwoo Park, Giovanni B. Brandani, Taekjip Ha, Gregory D. Bowman
Summary: Chromatin remodelers use a helicase-type ATPase motor to shift DNA and exhibit a sequence-dependent bias in nucleosome positioning, which is influenced by local DNA perturbations throughout the nucleosome footprint.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Migle Tomkuvien, Markus Meier, Diana Ikasalaite, Julia Wildenauer, Visvaldas Kairys, Saulius Klimasauskas, Laura Manelyt
Summary: Methylation of cytosine is an important epigenetic mark that can alter DNA and chromatin structure. This study investigates how larger chemical variations in DNA affect chromatin structure and nucleosome formation.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuri A. Purtov, Olga N. Ozoline
Summary: Hormones and neurotransmitters can affect bacterial physiology, metabolism, and gene expression, and recent studies have shown that they can directly penetrate bacteria. By occupying the effector binding sites, neuromodulators can modulate the activity of bacterial transcription factors. Therefore, neuromodulators may preadapt bacteria to their habitat by perceiving host signaling molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chien Chen, Szu-Yu Tung, Chia-Wei Huang, Soo-Wah Gan, Bo-Chi Lin, Chia-Wei Chen, Zi-Qi Lin, Chin-Hung Sun
Summary: This study investigated the role of the topoisomerase Spo11 in the encystation process of Giardia lamblia. The findings indicate that Spo11 acts as a positive regulator in activating encystation, interacting with transcription factors involved in cwp gene expression for cyst formation. Disruption of the spo11 gene led to decreased cwp gene expression and cyst formation, highlighting the importance of Spo11 in regulating Giardia differentiation into cysts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Eugeniya I. Bondar, Maxim E. Troukhan, Konstantin V. Krutovsky, Tatiana V. Tatarinova
Summary: This study utilized computational approaches to predict genome-wide TSS in four conifer species, laying the groundwork for future research on gene regulatory regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Yibo Zhu, Bingnan Luo, Xingyu Mou, Yingjie Song, Yonghong Zhou, Yongbo Luo, Bo Sun, Youfu Luo, Hong Tang, Zhaoming Su, Rui Bao
Summary: TetR family regulators are widely distributed in bacteria and archaea and play vital roles in regulating gene expression and physiological processes. The newly discovered PvrA protein is a transcriptional activator that can simultaneously bind to multiple sites and upregulate target gene expression, providing new insights into the regulation mechanism of P. aeruginosa virulence.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Li Huang, Youwang Wang, Haizhen Long, Haoqiang Zhu, Zengqi Wen, Liwei Zhang, Wenhao Zhang, Zhenqian Guo, Longge Wang, Fangyi Tang, Jie Hu, Keyan Bao, Ping Zhu, Guohong Li, Zheng Zhou
Summary: This study reveals the interaction between SUV420H1 and H2A.Z-nucleosome or H2A-nucleosome through cryo-EM structures. It demonstrates that SUV420H1 directly interacts with H4 N-terminal tail, the DNA, and the acidic patch in the nucleosome. The study also highlights the crucial role of the SUV420H1 KR loop in the preferential recognition of H2A.Z-nucleosome.
Article
Microbiology
Barbara Pees, Wentao Yang, Anke Kloock, Carola Petersen, Lena Peters, Li Fan, Meike Friedrichsen, Sabrina Butze, Alejandra Zarate-Potes, Hinrich Schulenburg, Katja Dierking
Summary: The study focused on C. elegans CLEC proteins, specifically clec-4, clec-41, and clec-42, and found that they play diverse roles in immunity. CLEC-4 functions in regulating feeding behavior to enhance resistance, while CLEC-41 and CLEC-42 act as antimicrobial proteins directly interacting with bacteria to defend against pathogen infection. The functional diversification of CLEC gene paralogs contributes to understanding the evolution of innate and invertebrate immune systems.
Article
Biochemistry & Molecular Biology
Shanshan Qiu, Anfei Fang, Xinhang Zheng, Shanzhi Wang, Jiyang Wang, Jing Fan, Zongtao Sun, Han Gao, Jiyun Yang, Qingtao Zeng, Fuhao Cui, Wen-Ming Wang, Jianping Chen, Wenxian Sun
Summary: In this study, a crucial virulence effector, SCRE4, was identified and characterized in U. virens. SCRE4 suppressed the expression of the immune positive modulator OsARF17, contributing to the infection process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
David Filipovic, Wenjie Qi, Omar Kana, Daniel Marri, Edward L. LeCluyse, Melvin E. Andersen, Suresh Cuddapah, Sudin Bhattacharya
Summary: The aryl hydrocarbon receptor (AhR) is a receptor that binds to environmental contaminants and its binding is tissue-specific and influenced by DNA sequences and chromatin context.
TOXICOLOGICAL SCIENCES
(2023)
Article
Virology
Myriam Scherer, Victoria Otto, Joachim D. Stump, Stefan Klingl, Regina Mueller, Nina Reuter, Yves A. Muller, Heinrich Sticht, Thomas Stamminger
JOURNAL OF VIROLOGY
(2016)
Article
Cell Biology
Walter Schaefer, Rita A. Eckart, Benedikt Schmid, Hasret Cagkoeylue, Kerstin Hof, Yves A. Muller, Bushra Amin, Anja Luehrmann
CELLULAR MICROBIOLOGY
(2017)
Article
Biochemical Research Methods
Kristin Rudolph, Christoph Parthier, Claudia Egerer-Sieber, Daniel Geiger, Yves A. Muller, Wolfgang Kreis, Frieder Mueller-Uri
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2016)
Article
Biochemical Research Methods
Madhumati Sevvana, Kristin Hasselt, Florian C. Grau, Andreas Burkovski, Yves A. Muller
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Karin Schmidt, Bernd R. Gardill, Alina Kern, Peter Kirchweger, Michael Boersch, Yves A. Muller
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Tanja Bartoschik, Stefanie Galinec, Christian Kleusch, Katarzyna Walkiewicz, Dennis Breitsprecher, Sebastian Weigert, Yves A. Muller, Changjiang You, Jacob Piehler, Thomas Vercruysse, Dirk Daelemans, Nuska Tschammer
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Bernd R. Gardill, Karin Schmidt, Yves A. Muller
JOURNAL OF STRUCTURAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yves A. Muller, Sigrun Haege, Sewar Alkhashrom, Tobias Hoellriegl, Sebastian Weigert, Simon Dolles, Kerstin Hof, Sascha A. Walzer, Claudia Egerer-Sieber, Marcus Conrad, Stephanie Holst, Josephine Loesing, Eric Sonntag, Heinrich Sticht, Jutta Eichler, Manfred Marschall
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Florian C. Grau, Jeannine Jaeger, Florian Groher, Beatrix Suess, Yves A. Muller
NUCLEIC ACIDS RESEARCH
(2020)
Article
Biochemical Research Methods
Stefan Klingl, Sina Kordes, Benedikt Schmid, Roman G. Gerlach, Michael Hensel, Yves A. Muller
PROTEIN EXPRESSION AND PURIFICATION
(2020)
Review
Virology
Manfred Marschall, Sigrun Haege, Marcus Conrad, Sewar Alkhashrom, Jintawee Kicuntod, Johannes Schweininger, Mark Kriegel, Josephine Loesing, Julia Tillmanns, Frank Neipel, Jutta Eichler, Yves A. Muller, Heinrich Sticht
Article
Biochemical Research Methods
Florian C. Grau, Andreas Burkovski, Yves A. Muller
Summary: P-II proteins are involved in regulating nitrogen/carbon balance in bacteria, archaea, plants, and algae through signal transduction modulated by effector molecules and post-translational modifications. The crystal structures of GlnK from Corynebacterium glutamicum, both adenylylated and unmodified, provide insights into the structural implications of covalent attachment of an AMP moiety to the T-loop. Adenylylation of GlnK does not alter the overall fold and does not interfere with the formation of functionally important T-loop conformations.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2021)
Article
Microbiology
Johannes Schweininger, Myriam Scherer, Franziska Rothemund, Eva-Maria Schilling, Sonja Worz, Thomas Stamminger, Yves A. Muller
Summary: Cytomegaloviruses have evolved a species-specific IE1 protein tertiary structure to effectively bind and inactivate the important cellular restriction factor PML, forming a barrier to cross-species transmission. The highly conserved fold of IE1 maximizes the efficacy of PML targeting in a species-specific manner, illustrating the co-evolution of viruses and their hosts.