Article
Biochemistry & Molecular Biology
Wenchao Xu, Taotao Sun, Jiaxin Wang, Tao Wang, Shaogang Wang, Jihong Liu, Hao Li
Summary: GPX4 improves erectile function by modulating ferroptosis in diabetes mellitus-induced erectile dysfunction (DMED), providing a potential target in deciphering the molecular mechanism of hyperglycemia-induced ferroptosis.
Review
Oncology
Bartlomiej Salata, Agnieszka Kluczna, Tomasz Dzierzanowski
Summary: Sexual disorders are common in cancer patients and often overlooked. Opioid drugs play a major role in causing sexual dysfunction, although the exact mechanisms are still being studied. Treatment options are limited and should be personalized based on the underlying pathology.
Article
Endocrinology & Metabolism
Jingxuan Peng, Dongjie Li, Longyun Liu, Yali Xiang, Yuxin Tang
Summary: This study investigated the differences between diabetes-induced erectile dysfunction (DMED) and non-diabetic erectile dysfunction (ED), as well as the characteristics of ED of varying severity in the two groups. The results showed significant differences in age, physical indicators, and biochemical indicators between the two groups. The findings can provide important reference for clinical treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lei Zhang, Binghao Bao, Jianqiang Guo, Zhongjian Qin, Haonan Huang, Lu Chen, Baoxing Liu
Summary: This study conducted a bibliometric analysis of literature on diabetes mellitus-induced erectile dysfunction (DMED) and discussed the research hotspots and future development directions in this field. The results showed that the Journal of Sexual Medicine published the most articles (92 articles), and the United States and China were leading in DMED research. Cross-institutional collaboration on DMED research worldwide needs to be strengthened. The main research hotspots in DMED included mechanism discussions and disease treatment and management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chandrasekar Palanichamy, Damodar Nayak Ammunje, Parasuraman Pavadai, Sureshbabu Ram Kumar Pandian, Panneerselvam Theivendren, Shanmugampillai Jeyarajaguru Kabilan, Ewa Babkiewicz, Piotr Maszczyk, Selvaraj Kunjiappan
Summary: This study demonstrates the significant effects of Mimosa pudica Linn. extract on the male sexual system of rats with diabetes, including scavenging excessive free radicals and alleviating the deleterious effects of diabetes. The extract improves body weight, reproductive organ weight, sperm characteristics, and testes histocellular arrangement in rats. Additionally, it increases hormone levels and antioxidant enzymes while reducing oxidative stress markers in both serum and testicular homogenates. In silico molecular docking also predicts high potential compounds in the extract that show binding affinities with the PDE5 receptor. Overall, ethanolic extract of M. pudica L. exhibits significant aphrodisiac performance in diabetic rats.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Wenchao Xu, Hongyang Jiang, Jihong Liu, Hao Li
Summary: Erectile dysfunction is a common sexual dysfunction in males, and diabetes-induced erectile dysfunction differs significantly from non-diabetic erectile dysfunction. However, the role of non-coding RNAs in diabetes-induced erectile dysfunction is still not well-studied.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Steven M. Hollenberg, Mervyn Singer
Summary: This review explores the definition, epidemiology, diagnosis and pathophysiology of septic cardiomyopathy, focusing on interpreting this condition in the clinical context. Advances in diagnostic techniques have increased sensitivity in detecting myocardial abnormalities, posing challenges in linking these abnormalities to therapeutic strategies. Sophisticated methodologies have elucidated various pathophysiological mechanisms, but the question of whether these are adaptive responses remains to be definitively answered.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Plant Sciences
Jian Xiong Ma, Bin Wang, Hai Song Li, Jia Yu, Hui Min Hu, Cai Fei Ding, Wang Qiang Chen
Summary: Through network pharmacology and chemical analysis, this study identified the potential therapeutic mechanisms of LCG on DMED, revealing common target genes between LCG and DMED, elucidating the regulation of nine hub genes by LCG in DMED, and its effects on multiple signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Bedoor Qabazard, Mariam Yousif, Alyaa Mousa, Oludotun Adebayo Phillips
Summary: The study investigates the potential protective role of hydrogen sulfide in diabetes-induced erectile dysfunction, with findings suggesting that H2S may reduce corporal contraction and fibromuscular changes in diabetic penile tissue, as well as having a link with plasma/urinary levels. These findings indicate that H2S could be a new strategy for preventing and treating diabetes-induced ED.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Samantha Klaas, Jessica Barbut Siva, Maarten Bak, Mark Govers, Rudy Schreiber
Summary: Although PSSD has been recognized as a medical condition, it is still largely unknown and under-diagnosed. This study aims to understand the symptomatology, mechanisms, and treatment options of PSSD through a design thinking approach. Insights from a targeted patient's needs and pains were used to generate new ideas, which informed a literature search on potential pathophysiological mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Mohammad Dweib, Nuha El Sharif
Summary: This study investigated the factors associated with diabetes-related microvascular complications among individuals with diabetes in the West Bank of Palestine. The results showed that age, education level, residency location, and adherence to diabetes management guidelines were all associated with the occurrence of microvascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Sangiorgi, Alberto Cereda, Daniela Benedetto, Michela Bonanni, Gaetano Chiricolo, Linda Cota, Eugenio Martuscelli, Francesco Greco
Summary: Erectile dysfunction (ED) is the inability to achieve or maintain sufficient erection for successful sexual intercourse, significantly impacting life quality and relationships. Atherosclerosis of penile arteries is a common cause, warranting investigation for potential coexisting diseases. Understanding the pathophysiology and molecular basis has led to advancements in pharmacological and mechanical treatments for ED.
Article
Plant Sciences
Ruxandra Stefanescu, Lenard Farczadi, Adina Hutanu, Binca E. Osz, Marius Marusteri, Ancuta Negroiu, Camil E. Vari
Summary: The study evaluated the mechanisms of action of Tribulus terrestris extracts in diabetes, finding that they can lower blood glucose levels and increase follicle-stimulating hormone and testosterone levels.
Article
Multidisciplinary Sciences
Rui Gao, Qi Fu, He-Min Jiang, Min Shen, Rui-Ling Zhao, Yu Qian, Yun-Qiang He, Kuan-Feng Xu, Xin-Yu Xu, Heng Chen, Quan Zhang, Tao Yang
Summary: By conducting temporal RNA sequencing and longitudinal analysis of metabolic characteristics, we found that high-fat diet induced diabetes led to dynamic deterioration of islet function, variable development of insulin resistance in different tissues, and joint programming of beta-cell compensatory adaptation and irreversible islet dysfunction by islets and liver.
Article
Andrology
Wenchao Xu, Taotao Sun, Jiaxin Wang, Tao Wang, Shaogang Wang, Jihong Liu, Kang Liu, Hao Li
Summary: This study revealed the presence of ferroptosis in diabetes-induced erectile dysfunction. GPX4, SLC7A11, and ACSL4 play important roles in controlling the viability of smooth muscle cells and may serve as potential therapeutic targets.