Article
Biochemistry & Molecular Biology
Ewa Stepien, Jakub Dworzanski, Anna Dworzanska, Bartlomiej Drop, Malgorzata Polz-Dacewicz
Summary: In patients with type 2 diabetes, EBV infection may lead to significant differences in the concentration of MMP-3 and MMP-9. MMPs may be useful biomarkers in the diagnosis, prognosis, and monitoring of diabetes associated with EBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney
Summary: Extracellular proteolysis and turnover play crucial roles in tissue homeostasis. MMPs, as the main matrix-degrading enzymes, are regulated by TIMPs. The balance between MMP activity and TIMP levels is essential for healthy tissue homeostasis and can be disrupted in pathological conditions.
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Infectious Diseases
Bastian Lubis, Aznan Lelo, Putri Amelia, Agus Prima
Summary: This study was a randomized controlled trial examining the effects of vitamin C and thiamine in septic patients. The study found that thiamine alone provided better advantages than either vitamin C alone or their combination.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Zdanowicz, Monika Kowalczuk-Kryston, Witold Olanski, Irena Werpachowska, Wlodzimierz Mielech, Dariusz Marek Lebensztejn
Summary: This study explores the early effects of alcohol intoxication on liver fibrosis in adolescents. The results show that even a single episode of alcohol intoxication can lead to an imbalance in markers of fibrosis.
Article
Pharmacology & Pharmacy
Kuang-Yi Tseng, Hung-Chen Wang, Kai-Feng Cheng, Yi-Hsuan Wang, Lin-Li Chang, Kuang- Cheng
Summary: Intrafascicular nerve injection can induce neuropathy through the dramatic but transient increases in enzymatic activities of MMP-9 and activating TIMP-1 in the operated nerves, leading to extracellular matrix degradation and endoneurial vascular permeability increase.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arno Kirchhain, Asta Zubriene, Visvaldas Kairys, Federico Vivaldi, Andrea Bonini, Denise Biagini, Delio Santalucia, Daumantas Matulis, Fabio Di Francesco
Summary: Matrix metalloproteinases play a crucial role in cancer progression and metastasis, and molecular probes have been successfully used to study their activity. In this study, a series of MMP-2 and MMP-9 binding probes were synthesized, showing high selectivity against MMP-2 and potential for sensor fabrication. The experimental results were confirmed by molecular modeling, indicating the potential application of these probes for targeted enzyme detection.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Deep Sankar Rudra, Uttam Pal, Nilkanta Chowdhury, Nakul Chandra Maiti, Angshuman Bagchi, Snehasikta Swarnakar
Summary: The repairing of damaged tissues in the gastric tract starts with extracellular matrix remodeling by matrix metalloproteinases (MMPs). The drug omeprazole, used to cure gastric ulcers, has been shown to restore MMP-2 activity and reduce apoptosis, preventing stress-induced gastric ulcers by modulating NF-kappa B and PPAR-gamma activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Psychiatry
Cansu Mercan Isik, Ayla Uzun Cicek, Dilara Ulger, Sevtap Bakir
Summary: This study evaluated the potential role of MMP-9, TIMP-1, and SIRT-1 in the etiology of Specific Learning Disorder (SLD). The findings showed lower serum MMP-9 levels and higher TIMP-1 levels in children with SLD compared to the control group, and the severity of SLD was negatively correlated with MMP-9 levels and positively correlated with TIMP-1 levels. These results suggest that MMP-9 may contribute to memory and learning in SLD by modulating synaptic plasticity, and the deregulation of the MMP-9/TIMP-1 ratio may play a role in SLD. Understanding these molecular pathways could help in the discovery of biomarkers and new treatment possibilities for SLD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Joana Mota, Rosa Direito, Joao Rocha, Joao Fernandes, Bruno Sepodes, Maria Eduardo Figueira, Anabela Raymundo, Ana Lima, Ricardo Boavida Ferreira
Summary: The study isolated and characterized an MMP-2 and -9 inhibitor from Lupinus albus, showing its efficacy in inhibiting MMP-9 activity in colon cancer cells and significantly reducing colitis symptoms in a mouse model. This novel type of MMP inhibitor in lupine, edible and proteinaceous in nature, holds high potential for application as a nutraceutical or functional food targeting pathologies related to high MMP-9 activity in the digestive system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Marwa Ben Ali Gannoun, Nozha Raguema, Hedia Zitouni, Meriem Mehdi, Ondrej Seda, Touhami Mahjoub, Julie L. Lavoie
Summary: This study found an increased frequency of heterozygous MMP-9 -1562 C/T genotype carriers in women with preeclampsia compared to healthy controls, suggesting it could be a genetic risk factor for preeclampsia in Tunisian women. However, there was no significant difference in the frequency distribution of the allele and genotype of MMP-2 -735 C/T polymorphism between healthy pregnant women and those with preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Isabel Santos, Ana Lima, Joana Mota, Patricia Rebelo, Ricardo Boavida Ferreira, Laurentina Pedroso, Maria Adelia Ferreira, Isabel Sousa
Summary: This study found that fermentation with specific lactic acid bacteria produced peptides with antibacterial activity, one of which derived from beat casein. This peptide showed effectiveness against various pathogens, inhibited metalloproteases, and reduced cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Juanjuan Song, Ligang Yuan, Hua Wang, Guojuan Chen, Shaoyu Chen
Summary: This study investigated the distribution and expression of MMP-2 and TIMP-2 in yak testes. The results showed that MMP-2 and TIMP-2 were mainly located in different cell types at different ages. The expression levels of MMP-2 and TIMP-2 varied with age, with a decrease from newborn to adult and an increase in old yaks. This study revealed the possible roles of MMP-2 and TIMP-2 in testicular functionality of yaks at different ages.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Biochemistry & Molecular Biology
Jessica Ares Blanco, Carmen Lambert, Manuel Fernandez-Sanjurjo, Paula Morales-Sanchez, Pedro Pujante, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Edelmiro Menendez Torre, Elias Delgado
Summary: The aim of this study was to investigate the glucose tolerance status after 15 years of pregnancy in women diagnosed with gestational diabetes mellitus (GDM) and to assess the long-term effect of GDM on circulating miRNA profile. The study included 30 randomly selected women diagnosed with GDM during 2005-2006, and glucose tolerance was measured using the National Diabetes Data Group criteria. Four miRNAs were analyzed in the plasma of women 15 years after the diagnosis of GDM. The study found that 50% of women had some degree of glucose intolerance 15 years after the diagnosis of GDM, which was directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed significantly increased levels of circulating hsa-miR-24-3p. Thus, initial weight and BMI, along with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ioanna A. Anastasiou, Ioanna Eleftheriadou, Anastasios Tentolouris, Chrysi Koliaki, Ourania A. Kosta, Nikolaos Tentolouris
Summary: Oxidative stress is implicated in many diseases, particularly in pancreatic beta-cell dysfunction and apoptosis associated with diabetes. Antioxidants, especially natural extracts, have shown protective effects on pancreatic beta-cells in vitro and in vivo, while evidence for the antioxidant effects of antidiabetic drugs is limited.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ioanna A. Anastasiou, Ioanna Eleftheriadou, Anastasios Tentolouris, Iordanis Mourouzis, Constantinos Pantos, Nikolaos Tentolouris
Summary: This mini-review presents current literature data on the role of L-glucose in cancer diagnosis, highlighting the specific uptake of L-glucose fluorescent probes by malignant cancer cells. Limited studies have examined the ability of cancer cells to take up L-glucose, suggesting the potential use of L-glucose fluorescent probes for visualization and characterization of cancer cells. Further research on the biological effects of L-glucose in cancer is warranted.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Marianne Benn, Frida Emanuelsson, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: The study found a causal relationship between high plasma glucose levels and increased risk of ischemic stroke. Glucose-lowering drugs such as glucagon-like peptide-1 receptor agonists and thiazolidinediones were shown to reduce the risk of stroke. These results may help guide clinicians in treating individuals at high risk for ischemic stroke.
Review
Endocrinology & Metabolism
Nikolaos Tentolouris, Georgia Samakidou, Ioanna Eleftheriadou, Anastasios Tentolouris, Edward B. Jude
Summary: This meta-analysis suggests that vitamin D supplementation is beneficial for ICU admission in COVID-19 patients, but not for mortality. Further research is needed to understand the benefits of vitamin D in COVID-19.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Nutrition & Dietetics
Christina Fytili, Theodora Nikou, Nikolaos Tentolouris, Ioulia K. Tseti, Charilaos Dimosthenopoulos, Petros P. Sfikakis, Dimitrios Simos, Alexandros Kokkinos, Alexios L. Skaltsounis, Nikolaos Katsilambros, Maria Halabalaki
Summary: This study aimed to investigate the potential effect of Hydroxytyrosol (HT) on human obesity. The results showed significant weight and visceral fat mass loss after 4 weeks of intervention in the group receiving the maximum HT dosage. This is the first study using a human cohort for a prolonged period of obesity research.
Article
Immunology
Eleni Papadokostaki, Anastasios Tentolouris, Ioanna A. Anastasiou, Mina Psichogiou, Evangelia Iliaki, Ioanna Eleftheriadou, Angelos Hatzakis, Nikolaos Tentolouris
Summary: The mRNA-based BNT162b2 vaccine showed high efficacy against severe SARS-CoV-2 infection. Limited data is available regarding the immune response in people with diabetes after vaccination with the BNT162b2 vaccine. This study found that almost 17% of participants with diabetes did not develop adequate immune response after the first dose, but the response became high and similar between participants with and without diabetes after the second dose, and remained stable even two months after the second dose. There was no significant difference in antibody levels between participants with and without diabetes throughout the study. At least two doses of the BNT162b2 vaccine are required for sufficient and sustainable immune response in people with diabetes.
Article
Biochemistry & Molecular Biology
Maroula G. Kokotou, Christiana Mantzourani, Charikleia S. Batsika, Olga G. Mountanea, Ioanna Eleftheriadou, Ourania Kosta, Nikolaos Tentolouris, George Kokotos
Summary: This study presents a fast and straightforward liquid chromatography-high resolution mass spectrometry method for the simultaneous determination of 74 free fatty acids (FFAs) in human plasma. The method avoids derivatization steps and tedious sample preparation, making it suitable for the diagnosis and monitoring of metabolic disorders.
Letter
Cardiac & Cardiovascular Systems
Ourania Zacharopoulou, Georgia Samakidou, Ioanna Eleftheriadou, Anastasios Tentolouris, Nikolaos Chatzieleftheriou, Ourania Kosta, Nikolaos Tentolouris
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Article
Nutrition & Dietetics
Nikolaos Perakakis, Alexander Kokkinos, Angeliki M. Angelidi, Dimitrios Tsilingiris, Anna Gavrieli, Maria Yannakoulia, Nicholas Tentolouris, Christos S. Mantzoros
Summary: This study investigates the concentration changes of PGDPs after oral or intravenous intake of different nutrients and finds that their levels are regulated by body weight, administration route, and nutrient type. Obese individuals have increased levels of PGDPs before and after meals, which remain elevated after a mixed meal test.
CLINICAL NUTRITION
(2022)
Review
Environmental Sciences
Stamatina Driva, Aliki Korkontzelou, Serena Tonstad, Nikolaos Tentolouris, Paraskevi Katsaounou
Summary: Smokers with diabetes mellitus can substantially lower their risks of microvascular and macrovascular diabetic complications, particularly cardiovascular disease, by quitting smoking. However, post-smoking-cessation weight gain may negate some of the benefits of quitting smoking and discourage further attempts to quit. Weight gain can transiently exacerbate diabetes and worsen glycemic control and metabolic profile.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Diego Moriconi, Monica Nannipieri, Prince Dadson, Javier Rosada, Nikolaos Tentolouris, Eleni Rebelos
Summary: Obesity is an independent risk factor for chronic kidney disease, but weight loss induced by bariatric surgery can improve obesity-related glomerulopathy and renal function. However, assessing the impact of obesity and weight loss on renal function is challenging.
Article
Ophthalmology
Katrine L. L. Rasmussen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard, Ruth Frikke-Schmidt
Summary: This study aims to determine the association between genetic variations in the apolipoprotein E (APOE) gene and the risk of age-related macular degeneration (AMD). The results suggest that structural variations in the APOE gene may be important for the risk of AMD in individuals of European ancestry.
JAMA OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Gian Paolo Fadini, Cristobal Morales, Irene Caballero, Beatriz Gonzalez, Nikolaos Tentolouris, Agostino Consoli
Summary: This study extends a previous analysis of real-world data in patients with type 2 diabetes initiating dapagliflozin in Italy, Greece, and Spain. The results confirm the efficacy of dapagliflozin in reducing HbA1c in diverse real-world settings, with similar effects across countries and baseline characteristics.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Nutrition & Dietetics
Konstantinos Stefanakis, Alexander Kokkinos, Stamatia Simati, Georgia Argyrakopoulou, Sofia K. Konstantinidou, Matina Kouvari, Ajay Kumar, Bhanu Kalra, Christos S. Mantzoros
Summary: This study measured the levels of all proglucagon-derived peptides (PGDPs) in response to three mixed meal tolerance tests (MMTs), comparing postprandial PGDP responses between lean and obese subjects and between high-fat and high-carbohydrate meals. The results showed that the fat and carbohydrate content of a meal can significantly affect the postprandial levels of PGDPs, and the presence of leanness or obesity also influences the circulating levels of select PGDPs.
CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Edward B. Jude, Nikolaos Tentolouris, Ashu Rastogi, Moi H. Yap, Hermelinda C. Pedrosa, Stephanie F. Ling
Summary: This survey has shown that many clinicians prescribe vitamin D for the prevention and treatment of COVID-19, especially in Asia. Most doctors also recommend measuring vitamin D levels, but it is not common in patients with COVID-19.
HEALTH SCIENCE REPORTS
(2022)
