Article
Biology
Jiye Kim, Gilsung Yoo, Taesic Lee, Jeong Ho Kim, Dong Min Seo, Juwon Kim
Summary: This study proposed a classification model for diabetic foot, necrotizing fasciitis (NF), and osteomyelitis (OM), and demonstrated their remarkable discriminatory power and applicability in clinical settings.
Article
Immunology
Nan Chen, Jie Deng, Zhihui Zhang, Xia Feng, Hongkang Wang, Jian Chen, Ling Li, Yemin Cao, Chenglin Jia, Yongbing Cao
Summary: Research suggests that diabetic patients are more susceptible to skin infections with Candida albicans, but the exact mechanism is still unclear. A study using diabetic mouse footpad infection model and molecular biotechnology revealed that intense oxidative stress response mediated the activation of NF-kappa B protein complex and triggered downstream pyroptosis and apoptosis through NLRP3 inflammasome, potentially leading to severe infectious skin injuries in diabetic mice.
MICROBIAL PATHOGENESIS
(2022)
Article
Medicine, General & Internal
Sowmya Kandregula, Aparna Behura, Chinmaya R. Behera, Dipti Pattnaik, Amaresh Mishra, Bandita Panda, Subrat Mohanty
Summary: This study investigated the prevalence of fungal infections in diabetic foot ulcers (DFUs). The results showed that 31.7% of DFUs were infected with fungus. It was recommended to perform fungal culture and appropriate antifungal treatment for better healing outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
David G. Armstrong, Tze-Woei Tan, Andrew J. M. Boulton, Sicco A. Bus
Summary: Approximately 18.6 million people worldwide are affected by diabetic foot ulcers each year, with 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people with diabetes and are associated with an increased risk of death.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Paola Caruso, Maria Ida Maiorino, Lorenzo Scappaticcio, Chiara Porcellini, Rita Matrone, Paolo Cirillo, Margherita Macera, Maurizio Gicchino, Maria Teresa Vietri, Giuseppe Bellastella, Nicola Coppola, Katherine Esposito
Summary: This study aimed to evaluate PTH levels in individuals with diabetic foot ulcers (DFU) and investigate the relationship between PTH levels and osteomyelitis (OM) in this population. The results showed that PTH levels were lower in DFU patients with OM compared to those without OM, and alkaline phosphatase levels were higher in the OM group. OM and alkaline phosphatase levels were independent predictors of PTH levels in this selected population.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Ying Tang, Yixuan Huang, Li Luo, Murong Xu, Datong Deng, Zhaohui Fang, Xiaotong Zhao, Mingwei Chen
Summary: This study aims to investigate the correlation between vitamin D deficiency and diabetic foot osteomyelitis (DFO), and explore the potential biomarkers for the diagnosis and prognosis of diabetic foot ulcer (DFU) and DFO. The results showed that the levels of serum 25(OH)VD and T-VDR expression decreased in patients with DFU and DFO, and were associated with treatment outcomes and diagnosis.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Endocrinology & Metabolism
Yan-Jun Hu, Chen-Sheng Song, Nan Jiang
Summary: Diabetes mellitus is a global health problem, and the increasing number of patients with diabetic foot ulcers (DFU) poses many challenges to physicians. Recent findings have identified single-nucleotide variations (SNVs) in several genes that may be associated with DFU development. Further multi-center studies with larger sample sizes and in-depth mechanistic research are needed to better understand DFU pathogenesis.
WORLD JOURNAL OF DIABETES
(2022)
Article
Dermatology
Eran Tamir, Oded Rabau, Yiftah Beer, Yossi Smorgick, Hanna Kaufman, Aharon S. Finestone
Summary: The objective of this study was to classify the anatomical deformities of first-ray ulcers and standardize treatment and reporting. Several biomechanical mechanisms related to anatomical deformities were identified through a review of patient files. The classification of anatomical deformities can guide the selection of corrective surgery.
ADVANCES IN SKIN & WOUND CARE
(2023)
Article
Endocrinology & Metabolism
Hassan Al-Balas, Zeyad A. Metwalli, Aaditya Nagaraj, David M. Sada
Summary: Foot infection, especially osteomyelitis, is a major risk factor for amputation in diabetic patients. Percutaneous fluoroscopy guided bone biopsy is a safe and accurate procedure that can provide valuable information about pathogens and their antibiotic susceptibility, allowing targeted treatment with narrow spectrum antibiotics.
JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Xuemei Li, Qingfeng Cheng, Zhipeng Du, Shenyin Zhu, Chao Cheng
Summary: The study found a higher microbiological concordance between soft tissue culture results and bone tissue culture results, which are suitable for identifying the bacteria in diabetic foot osteomyelitis (DFO). Antibiotic therapy should be chosen based on antimicrobial susceptibility testing in bone tissue specimen cultures.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Medicine, General & Internal
Sujit Kumar Das, Pinki Roy, Prabhishek Singh, Manoj Diwakar, Vijendra Singh, Ankur Maurya, Sandeep Kumar, Seifedine Kadry, Jungeun Kim
Summary: Diabetes is a chronic condition caused by uncontrolled blood sugar levels, and early diagnosis of complications such as diabetic foot ulcers (DFUs) can help prevent severe consequences. The use of deep learning, machine learning, and computer vision techniques provides promising solutions for assisting clinicians in diagnosing DFUs. This article provides a comprehensive overview of the current status of automatic DFU identification and highlights the dominance of CNN-based solutions in the field. It emphasizes the importance of combining traditional ML and advanced DL techniques for more reliable and efficient diagnostic decisions.
Review
Dermatology
Kwadwo Mponponsuo, R. Gary Sibbald, Ranjani Somayaji
Summary: Diabetic foot ulcers result from a combination of peripheral neuropathy, vascular compromise, and repetitive trauma, with a portion of patients developing diabetic foot infections and osteomyelitis. Diagnosis is primarily based on clinical criteria, with X-ray as the recommended imaging modality. Treatment involves surgical debridement and appropriate wound care.
ADVANCES IN SKIN & WOUND CARE
(2021)
Article
Public, Environmental & Occupational Health
Sohail Akhtar, Mujahid Latif, Omer Shabbir Ahmed, Aqsa Sarwar, Ayisham Alina, Muhammad Imran Khan
Summary: This study explores the prevalence of foot ulcers among diabetic patients in Punjab, Pakistan and identifies associated factors. The results indicate a relatively high prevalence of foot ulcers in Punjab, highlighting the need for better strategies and preventive measures to address this epidemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
