Article
Dermatology
Amal T. Abdel-Rahman, Fatma G. Abdel-Hakeem, Maha H. Ragaie
Summary: This study compared the efficacy of microneedling with vitamin C and PRP in treating mixed melasma, with vitamin C showing more significant results. Vitamin C was more effective in reducing melanin and melanophages, as well as MART-1 positive cells, compared to PRP.
DERMATOLOGIC THERAPY
(2022)
Review
Dermatology
Gabriela Correia, Sofia Magina
Summary: This systematic review evaluates the effectiveness of topical vitamin C in treating photoaging and melasma, and finds that vitamin C can improve uneven and wrinkled skin, has depigmenting properties, but long-term use may be needed for noticeable changes. Q-switched Nd:YAG laser-associated protocols enhance the effects of vitamin C. Topical vitamin C may be a suitable alternative for melasma and photoaging, but more studies are needed to confirm these results and assess the ideal vitamin C concentration.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Dermatology
Maryam Khalili, Rezvan Amiri, Behzad Iranmanesh, Hamed Zartab, Mahin Aflatoonian
Summary: Mesotherapy is a popular novel therapeutic modality in aesthetic dermatology, suitable for patients with melasma who are refractory to first-line therapy, have low compliance with topical treatment, or have contraindications to oral tranexamic acid therapy. Further studies with larger sample sizes are needed to determine the optimal concentration and injection intervals of mesotherapy substances, evaluate the efficacy of different substances, and compare them with other treatment modalities.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Yasmina El Attar, Noha Doghaim, Nashwa El Far, Samar El Hedody, Soha Abdalla Hawwam
Summary: The use of topical tranexamic acid or vitamin C after microneedling is an effective and safe technique for melasma treatment, with significant improvements in pigmented lesions and vascular components.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Dermatology
Adrian Joseph Michel Bailey, Heidi Oi-Yee Li, Marcus G. Tan, Wei Cheng, Jeffrey S. Dover
Summary: This study conducted a systematic review and meta-analysis on the efficacy of microneedling as an adjuvant to topical therapies for the treatment of melasma. The results showed that microneedling as an adjuvant therapy improved melasma severity significantly, with better results compared to topical therapy alone. Microneedling was well tolerated with no serious adverse events reported.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
J. Zoutendijk, S. Koljenovic, M. Wakkee, A. L. Mooyaart, T. Nijsten, R. R. van den Bos
Summary: This study investigated the use of clinical and dermoscopic mapping to increase the detection rate of lentigo maligna melanoma (LMM). The results showed that 8.6% of biopsy-proven LM were actually LMM, and the clinical guidance of dermatologists did not increase the detection rate of LMM.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Nutrition & Dietetics
Anitra C. Carr, Gladys Block, Jens Lykkesfeldt
Summary: This study suggests that individuals with higher body weights may need to consume additional vitamin C to reach comparable levels as lighter individuals, potentially underscoring the inadequacy of current recommendations for higher body weight individuals.
Review
Nutrition & Dietetics
Bianca J. Collins, Mitali S. Mukherjee, Michelle D. Miller, Christopher L. Delaney
Summary: Vitamin C supplementation can increase vitamin C levels in populations with or without cardiovascular disease, but further research is needed for different population groups with varying baseline vitamin C levels to update supplementation guidelines.
Review
Medicine, Research & Experimental
Takwa Bedhiafi, Sourour Idoudi, Queenie Fernandes, Lobna Al-Zaidan, Shahab Uddin, Said Dermime, Nashiru Billa, Maysaloun Merhi
Summary: Vitamin C is a crucial nutrient in humans with important physiological functions. However, its therapeutic applications are limited due to low chemical stability. Although there are some nano-encapsulation techniques described in the literature, there are few clinical investigations on the therapeutic applications of nano-encapsulated vitamin C. Further research is needed to explore the potential clinical benefits of nano-encapsulated vitamin C.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Haopeng Li, Miao Cai, Haitao Li, Zhengmin (Min) Qian, Katie Stamatakis, Stephen Edward McMillin, Zilong Zhang, Qiansheng Hu, Hualiang Lin
Summary: This study suggests that ambient air pollution is an important risk factor for diabetes mellitus, and sufficient intake of antioxidant vitamins may reduce the adverse effects of air pollution on diabetes mellitus.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Enrica Flori, Arianna Mastrofrancesco, Sarah Mosca, Monica Ottaviani, Stefania Briganti, Giorgia Cardinali, Angela Filoni, Norma Cameli, Marco Zaccarini, Christos C. Zouboulis, Mauro Picardo
Summary: This study explores the role of sebaceous glands in the development of melasma. It found that sebocytes exposed to UVA radiation produce a range of substances related to melanogenesis and inflammation. The experiments also demonstrated the promoting effect of sebocytes on melanogenesis and confirmed the existence of these effects in vivo through analysis of sebum from melasma patients.
Article
Biochemistry & Molecular Biology
Cristian Sandoval, Jorge Farias, Mauricio Zamorano, Christian Herrera
Summary: The present review examined the relationship between vitamin deficiency and chronic liver disease. It was found that alcohol patients have low blood vitamin levels and that antioxidant mechanisms can prevent alcohol-induced liver damage. However, the effectiveness of antioxidants remains uncertain. Deficiencies in nutritional vitamins can rapidly develop during chronic liver disease.
Article
Nutrition & Dietetics
Javier Moreno-Montanes, Elsa Gandara, Laura Moreno-Galarraga, Maria S. Hershey, Jose Francisco Lopez-Gil, Stefanos Kales, Maira Bes-Rastrollo, Miguel Angel Martinez-Gonzalez, Alejandro Fernandez-Montero
Summary: Previous studies have shown contradictory results regarding the association between antioxidant consumption and glaucoma. This study found that while individual intake of vitamins A, C, and E did not demonstrate a significant protective effect, their combined consumption was associated with a reduced risk of glaucoma.
Review
Nutrition & Dietetics
Anitra C. C. Carr, Masuma Zawari
Summary: The global healthcare burden of an aging population is increasing, with a significant portion of diseases attributed to older individuals. Micronutrient deficiencies, including vitamin C, are common among older people and can contribute to chronic illnesses. While there is limited evidence suggesting that healthy aging is associated with lower vitamin C levels or increased requirements, institutionalized elderly individuals tend to have lower vitamin C status and enhanced requirements due to poor intake and chronic illness. Appropriate nutritional interventions are necessary to support healthy aging in this vulnerable population.