期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 26, 期 1, 页码 7-15出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09546634.2013.860209
关键词
cardiovascular disease risk; disease characteristics; efficacy; etanercept
类别
资金
- Wyeth Research
- Pfizer Inc.
- Pfizer Inc
- Abbott
- Amgen
- Centers for Disease Control
- Janssen
- Novartis
Cardiometabolic, clinical and quality-of-life (QoL) measures were assessed before and after etanercept treatment in patients who had moderate-to-severe plaque psoriasis with and without psoriatic arthritis (PsA) in the PRISTINE trial. Adult patients were randomized to receive etanercept 50mg once weekly or twice weekly double-blind for 12 weeks; all patients subsequently received etanercept 50mg once weekly open-label through week 24. Metabolic syndrome was identified in 44 and 41% of patients with and without PsA, elevated blood pressure in 73 and 56% (p<0.05) and diabetes in 21 and 9% (p<0.01), respectively. Significant improvements from baseline in Psoriasis Area Severity Index were observed with etanercept therapy at all time points over 24 weeks (p<0.001) independent of PsA history. At baseline, patients with PsA had worse QoL than patients without PsA. After 24 weeks of etanercept, both groups had significant improvement from baseline in QoL, but the PsA group had greater improvement than that without PsA. Cardiovascular comorbidities were common in psoriasis patients with and without PsA, suggesting that clinicians need to be attentive to cardiometabolic parameters in this population. Worse QoL was demonstrated in PsA versus psoriasis alone. Regardless of patients' PsA status, treatment with etanercept significantly improved skin symptoms and QoL measures.
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