Article
Polymer Science
Ahmad M. Eid, Hani Naseef, Nidal Jaradat, Lina Ghanim, Roaa Moqadeh, Miasar Yaseen
Summary: The study aimed to create a BPO nanoemulgel formulation to enhance its antibacterial properties. The formulation was prepared by combining BPO nanoemulsion with Carbopol hydrogel, and its solubility was tested in different oils and surfactants. The results showed that the nanoemulgel formulation had better antimicrobial activity against bacteria and acne compared to the market product. In conclusion, nanoemulgel is a promising approach for delivering BPO as it improves drug stability and antibacterial efficacy.
Article
Pharmacology & Pharmacy
Uzma Nayeem, Aakriti Garg, Ayan Kumar Das, Neetu Shree, Yasmin Yasmeen, Yasmin Sultana, Shaista Ahmed, Mohd Ashif Khan
Summary: A novel chitosan-based transferosomal gel containing 1% clindamycin and 2.5% benzoyl peroxide was developed for the treatment of acne. The gel effectively encapsulated the active ingredients and demonstrated significant advantages in terms of skin deposition and permeation. In vivo studies on mice showed enhanced efficacy compared to standard treatment, with no skin irritation observed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Dermatology
Lin Zhou, Lingna Chen, Xueping Liu, Yukun Huang, Yong Xu, Xia Xiong, Yongqiong Deng
Summary: The study demonstrates that treatment with BPO can improve symptoms of acne vulgaris, but it may also decrease skin microbial diversity and damage the epidermal barrier.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
C. S. K. Fuchs, V. K. Ortner, F. S. Hansen, P. A. Philipsen, M. Haedersdal
Summary: A-BPO treatment improves skin micromorphology of acne patients by reducing sebum secretion and hyperkeratinization while increasing epidermal thickness. However, these changes do not significantly affect transfollicular delivery of microparticles.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Dermatology
Brigitte Dreno, Alison M. Layton, Patricia Troielli, Marco Rocha, Rajeev Chavda
Summary: Acne vulgaris is commonly treated with a combination of topical retinoids and antimicrobial agents. Adapalene 0.3%/BPO 2.5% is an approved medication for moderate-to-severe acne, with proven efficacy and safety across different patient profiles.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Linda Stein Gold, Edward Lain, James Q. Del Rosso, Michael Gold, Zoe D. Draelos, Lawrence F. Eichenfield, Neil Sadick, William P. Werschler, Melinda J. Gooderham, Mary Lupo
Summary: The IDP-126 gel, an innovative fixed-dose triple-combination treatment for acne, has shown promising efficacy and tolerability in two clinical studies involving participants with moderate-to-severe acne.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Lydia Szymanski, Krysten Lisella Arekapudi
Summary: Benzoyl peroxide (BPO) is commonly used for acne treatment, but it may cause skin irritation and other adverse reactions. Data collected from a monitoring system indicate that the reporting rate of BPO-related adverse events is less than 1%.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Susi Elaine Dal Belo, Leila Kanoun-Copy, Christina Lambert, Celine Cornillon, Benoit Muller, Hussein Jouni, Magali Moreau, Irina Palamarchuk, Delphine Kerob, Luc Aguilar
Summary: This study compares the efficacy of a dermocosmetic cream (DC-Eff) with benzoyl peroxide (BPO) gel in treating acne. The results show that DC-Eff is as beneficial as BPO in improving mild-to-moderate acne, and is better tolerated by patients.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Veronica K. Emmerich, Caitlin G. Purvis, Steven R. Feldman
Summary: Acne vulgaris is the most common skin condition worldwide, and is often associated with significant psychological comorbidity. Topical therapies, such as retinoids, antibiotics, and benzoyl peroxide, are the mainstay of treatment for acne patients. Adapalene/benzoyl peroxide gel is considered safe and highly effective compared to other topical therapies, but cost and lack of generic alternatives may limit its use.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Ivan Lukac, Branislav Husar, Martin Danko, Richard G. Weiss
Summary: The conversion of BZ to BP in polymer films under irradiation and the efficient method for chain crosslinking through thermal decomposition of BP pendant groups are highlighted. The use of BZ and BP derivatives provides convenient routes for modifying polymer chains, particularly in terms of crosslinking.
Article
Chemistry, Physical
Xiang Xu, You Yang, Yong Guan, Dafu Wei, Anna Zheng
Summary: Carbon nanotubes (CNTs) exhibit a remarkable catalytic effect on the decomposition of benzoyl peroxide (BPO) in ethanol. The decomposition of BPO by CNTs occurs via a free-radical pathway involving benzoate radicals. Multi-walled CNTs and single-walled CNTs contain persistent free radicals (PFRs) with strong electron-transfer ability.
Review
Pharmacology & Pharmacy
Christina Kontzias, Mallory Zaino, Steven R. Feldman
Summary: This study evaluated the efficacy, safety, and clinical application of 0.1% tretinoin-3% benzoyl peroxide cream. The cream significantly reduced acne lesions and improved assessment ratings. Compared to other acne treatments, it showed similar effectiveness but may have a higher cost.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Cell Biology
Bodo C. Melnik
Summary: This article provides insights into the pathogenesis of acne and the mode of action of isotretinoin through the study of acne transcriptomics. It reveals that puberty-induced IGF-1, insulin, and androgen signaling, as well as a Western diet, activate the AKT/mTORC1 signaling pathway, leading to the development of acne. Isotretinoin, on the other hand, inhibits sebum production by regulating the expression of p53, FoxO1, and FoxO3 and has various adverse effects.
Review
Medicine, General & Internal
Dawn Z. Eichenfield, Jessica Sprague, Lawrence F. Eichenfield
Summary: Acne vulgaris is a common inflammatory skin disease that affects approximately 9% of the global population. Treatment options include topical therapies for mild cases and systemic therapies for more severe cases, such as oral antibiotics or isotretinoin.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Engineering, Environmental
Wen-He Wang, Yan Huang, Shao-Yu Hu, Wei Su, Yong Pan, Chi-Min Shu
Summary: The study investigated the effect of hexanoic acid on the thermal decomposition of BPO, revealing that hexanoic acid increased the thermal hazard of BPO. Additionally, various kinetic models and decomposition mechanism function calculation methods were used to analyze the reaction process.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)