Article
Microbiology
Giovanna Mosaico, Giulia Artuso, Mara Pinna, Gloria Denotti, Germano Orru, Cinzia Casu
Summary: This study aims to investigate the effect of L. reuteri on facial skin in orthodontic patients. Two case reports showed that the use of L. reuteri as a probiotic during fixed orthodontic treatment significantly improved gum hypertrophy and acne vulgaris.
Article
Dermatology
Lin Zhou, Lingna Chen, Xueping Liu, Yukun Huang, Yong Xu, Xia Xiong, Yongqiong Deng
Summary: The study demonstrates that treatment with BPO can improve symptoms of acne vulgaris, but it may also decrease skin microbial diversity and damage the epidermal barrier.
DERMATOLOGIC THERAPY
(2022)
Editorial Material
Pharmacology & Pharmacy
Veronica K. Emmerich, Caitlin G. Purvis, Steven R. Feldman
Summary: Acne vulgaris is the most common skin condition worldwide, and is often associated with significant psychological comorbidity. Topical therapies, such as retinoids, antibiotics, and benzoyl peroxide, are the mainstay of treatment for acne patients. Adapalene/benzoyl peroxide gel is considered safe and highly effective compared to other topical therapies, but cost and lack of generic alternatives may limit its use.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Uzma Nayeem, Aakriti Garg, Ayan Kumar Das, Neetu Shree, Yasmin Yasmeen, Yasmin Sultana, Shaista Ahmed, Mohd Ashif Khan
Summary: A novel chitosan-based transferosomal gel containing 1% clindamycin and 2.5% benzoyl peroxide was developed for the treatment of acne. The gel effectively encapsulated the active ingredients and demonstrated significant advantages in terms of skin deposition and permeation. In vivo studies on mice showed enhanced efficacy compared to standard treatment, with no skin irritation observed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Dermatology
Brigitte Dreno, Alison M. Layton, Patricia Troielli, Marco Rocha, Rajeev Chavda
Summary: Acne vulgaris is commonly treated with a combination of topical retinoids and antimicrobial agents. Adapalene 0.3%/BPO 2.5% is an approved medication for moderate-to-severe acne, with proven efficacy and safety across different patient profiles.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Infectious Diseases
Madisen A. Swallow, Ryan Fan, Jeffrey M. Cohen, Christopher G. Bunick
Summary: Almost 1 billion people worldwide have acne, and oral tetracyclines are commonly prescribed for treatment. However, concerns about antibiotic resistance and side effects have arisen. Sarecycline, a narrow-spectrum tetracycline approved in 2018, shows promise in reducing resistance risk by targeting the pathogenic bacterium in acne vulgaris.
Article
Polymer Science
Ahmad M. Eid, Hani Naseef, Nidal Jaradat, Lina Ghanim, Roaa Moqadeh, Miasar Yaseen
Summary: The study aimed to create a BPO nanoemulgel formulation to enhance its antibacterial properties. The formulation was prepared by combining BPO nanoemulsion with Carbopol hydrogel, and its solubility was tested in different oils and surfactants. The results showed that the nanoemulgel formulation had better antimicrobial activity against bacteria and acne compared to the market product. In conclusion, nanoemulgel is a promising approach for delivering BPO as it improves drug stability and antibacterial efficacy.
Article
Dermatology
Dong Hyo Kim, Sukkyu Sun, Soo Ick Cho, Hyoun-Joong Kong, Ji Won Lee, Jun Hyo Lee, Dae Hun Suh
Summary: In this study, an automated algorithm was developed and validated to detect and count acne lesions by type. The algorithm showed clinically applicable performance and utility as an assistance tool for evaluating acne severity.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Dermatology
Dong Hyo Kim, Ji Hoon Yang, Soo Ick Cho, Ji Young Yoon, Ji Won Kim, Sungjun Choi, Dae Hun Suh
Summary: The clinical efficacy of epidermal growth factor ointment (EGFO) on acne and acne scars was evaluated in this study. The results indicated that EGFO significantly improved acne lesions and scars. Treatment with EGFO altered the expression of various factors related to acne and scarring.
Editorial Material
Dermatology
Lydia Szymanski, Krysten Lisella Arekapudi
Summary: Benzoyl peroxide (BPO) is commonly used for acne treatment, but it may cause skin irritation and other adverse reactions. Data collected from a monitoring system indicate that the reporting rate of BPO-related adverse events is less than 1%.
DERMATOLOGY AND THERAPY
(2022)
Review
Dermatology
Dillon J. Patel, Neal Bhatia
Summary: Oral antibiotics are crucial for treating inflammatory acne, but there are concerns about antibiotic resistance and phobia. Dermatologists need to carefully consider dosage, duration, and frequency when prescribing oral antibiotics, and avoid using them as monotherapy. Factors such as concomitant medications, allergies, and disease severity, as well as costs and patient demographics, can influence prescribing plans and variability.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Article
Health Care Sciences & Services
Karolina Chilicka, Aleksandra M. Rogowska, Renata Szygula
Summary: This study examined the effectiveness of hydrogen purification treatment for women with acne vulgaris, showing that the treatment significantly improved skin parameters, reduced sebum levels, and increased skin moisture. Therefore, topical hydrogen purification is an effective and safe treatment for acne vulgaris.
Article
Dermatology
Parvathy Santhosh, Mamatha George
Summary: Clascoterone is a topical drug approved by the FDA for the treatment of acne vulgaris, with a mechanism of action involving androgen receptor inhibition. It shows promising results in reducing acne symptoms with mild and infrequent adverse effects, and long-term safety studies have not shown systemic antiandrogenic effects in male participants.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
C. S. K. Fuchs, V. K. Ortner, F. S. Hansen, P. A. Philipsen, M. Haedersdal
Summary: A-BPO treatment improves skin micromorphology of acne patients by reducing sebum secretion and hyperkeratinization while increasing epidermal thickness. However, these changes do not significantly affect transfollicular delivery of microparticles.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Microbiology
Raja K. Sivamani, Jessica Maloh, Yvonne Nong
Summary: This study found that skin biophysical properties and acne lesion counts are closely correlated with stress levels and hormone levels in the blood. In addition, gut bacteria have different associations with inflammatory and non-inflammatory lesion counts. We hope that these findings will stimulate further research on the gut-mind-stress-skin axis within acne.
Review
Dermatology
Giuseppe Ingrasci, Nour El-Kashlan, Andrew Alexis, Gil Yosipovitch
Summary: Chronic pruritus disproportionately affects African Americans and racial differences in skin structure and function may contribute to the pathogenesis of itch in this population. Despite this, knowledge and management of pruritus in African Americans remain understudied and there is a significant unmet need in this area.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Letter
Dermatology
Daniel C. Butler, Eric Simpson, Emma Guttman-Yassky, Lawrence F. Eichenfield, Alexandra K. Golant, John Y. M. Koo, April W. Armstrong, Andrew F. Alexis, Peter A. Lio, Justin W. Marson, Mark Lebwohl
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Trisha Kaundinya, Uros Rakita, Armaan Guraya, Donna Maria Abboud, Emily Croce, Jacob P. Thyssen, Andrew Alexis, Jonathan Silverberg
Summary: The psychometric validity and reliability of widely used atopic dermatitis (AD) outcome measures across different races and ethnicities are unclear. This study systematically reviewed studies reporting psychometric properties of AD outcome measures and found a lack of consideration for race and ethnicity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Dermatology
Valerie D. Callender, Hilary Baldwin, Fran E. Cook-Bolden, Andrew F. Alexis, Linda Stein Gold, Eric Guenin
Summary: Acne is a common cause of post-inflammatory hyperpigmentation (PIH), which can be more distressing to patients than the acne itself. Topical retinoids are effective in treating PIH, especially in patients with skin of color, and should be started early. Patients should manage their expectations during treatment, and combining retinoids with other treatments like chemical peels can help improve symptoms.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Letter
Dermatology
Junko Takeshita, Matthias Augustin, Elke M. G. J. de Jong, Kimberly Parnell Lafferty, Wayne Langholff, Richard G. Langley, Alan Menter, Andrew F. Alexis
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Susan C. Taylor, Andrew F. Alexis, April W. Armstrong, Zelma C. Chiesa Fuxench, Henry W. Lim
Summary: Terrestrial sunlight, which includes UV radiation, visible light, and infrared radiation, has deleterious effects on skin health, particularly in individuals with light skin tones and skin of color. Despite evolving recommendations from medical societies and the US Food and Drug Administration, misconceptions about skin damage related to sunlight and the benefits of photoprotection are still prevalent. Skin disorders and impaired skin health due to sun exposure negatively impact the quality of life in individuals with skin of color.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Darrell S. Rigel, Susan C. Taylor, Henry W. Lim, Andrew F. Alexis, April W. Armstrong, Zelma C. Chiesa Fuxench, Zoe D. Draelos, Iltefat H. Hamzavi
Summary: In recent decades, the negative effects of sun exposure have gained better recognition. While most attention has been on the effects of UVB light, there is increasing appreciation for the effects of longer wavelengths, such as UVA and visible light. Studies have shown that visible light can cause hyperpigmentation in individuals with dark skin and exacerbate pigmentary disorders. However, there are still gaps in understanding the need for photoprotection and guidance for clinicians.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Andrew Alexis, Marjolein de Bruin-Weller, Stephan Weidinger, Weily Soong, Sebastien Barbarot, Ileana Ionita, Fan Zhang, Hernan Valdez, Claire Clibborn, Natalie Yin
Summary: This study investigated the effectiveness of abrocitinib in the treatment of atopic dermatitis (AD), finding that abrocitinib can rapidly and persistently improve symptoms of AD in different body regions, with particularly significant effects in difficult-to-treat areas such as the head and neck.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Andrew Alexis, Heather Woolery-Lloyd, Anneke Andriessen, John Koo, Amy McMichael, George Han
Summary: There is limited data on racial/ethnic variations, effects of skin care, and treatment implications for psoriasis patients with skin of color. Recognizing the impact of ethnicity on psoriasis can help reduce disparities in care and improve treatment outcomes.
JOURNAL OF DRUGS IN DERMATOLOGY
(2022)
Article
Allergy
Kristian Reich, Peter A. Lio, Robert Bissonnette, Andrew F. Alexis, Mark G. Lebwohl, Andrew E. Pink, Kenji Kabashima, Mark Boguniewicz, Roman J. Nowicki, Hernan Valdez, Fan Zhang, Marco DiBonaventura, Michael C. Cameron, Claire Clibborn
Summary: The study found that patients treated with abrocitinib and dupilumab had greater improvement in the symptoms and signs of moderate-to-severe atopic dermatitis compared to patients treated with placebo.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Dermatology
James Q. Del Rosso, Edward Lain, Jean Philippe York, Andrew Alexis
Summary: The clinical appearance and response to treatment of acne vulgaris may vary in people with skin of color compared with those with lighter skin types. This study demonstrates the favorable efficacy and safety of trifarotene 0.005% cream in treating facial and truncal acne in subjects with skin of color.
DERMATOLOGY AND THERAPY
(2022)
Review
Dermatology
Sami Jelousi, Divya Sharma, Andrew Alexis, Jenny E. Murase
Summary: Atopic dermatitis is a common inflammatory skin disease that significantly affects the quality of life for those affected. Patients with skin of color have a greater disease burden compared to patients of European descent. There is a lack of research on the burden of atopic dermatitis experienced by refugees and migrants. Displaced individuals face unique risk factors that make them particularly vulnerable to the disease.
DERMATOLOGY AND THERAPY
(2022)
Editorial Material
Dermatology
Andrew Alexis, J. Klint Peebles
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Hilary E. Baldwin, Andrew F. Alexis, Anneke Andriessen, Diane S. Berson, Julie Harper, Edward Lain, Shari Marchbein, Linda Stein Gold
Summary: This article presents an evidence-based clinical treatment and maintenance algorithm for the prevention, treatment, and management of rosacea. The algorithm includes foundational measures such as education, behavioral modifications, avoidance of triggers and skin irritants, preventative skincare, and sun avoidance and sunscreen use. The algorithm also provides guidance on assessing skin condition and grading of cutaneous rosacea during treatment and maintenance.
JOURNAL OF DRUGS IN DERMATOLOGY
(2022)
Article
Dermatology
Andrew Alexis, Heather Woolery-Lloyd, Anneke Andriessen, Seemal Desai, George Han, David Rodriguez
Summary: This article explores the clinical presentation and treatment considerations of rosacea in skin of color populations and discusses the role of cleansers and moisturizers in managing rosacea. The findings suggest that rosacea is more common in individuals with darker skin, but the clinical features may be less noticeable, leading to underdiagnosis. Using moisturizers and sunscreen has been shown to improve rosacea symptoms.
JOURNAL OF DRUGS IN DERMATOLOGY
(2022)