Article
Biotechnology & Applied Microbiology
Haruna Hori, Ayaka Kotani, Junya Abe, Shuji Matsuguchi, Yohei Hirai
Summary: The expression and processing of filaggrin in the skin epidermis is closely related to keratinocyte cornification. Extracellular EPM inhibits the expression of Pro-FLG and reduces the production of NMF in HaCaT keratinocytes.
Review
Biochemistry & Molecular Biology
Corinne Urwyler-Rosselet, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys, Wim Declercq
Summary: Receptor interacting protein kinases (RIPKs) are a family of enzymes that play important roles in integrating stress signals in the skin homeostasis. By activating various signaling pathways, RIPKs regulate the activation of NF-& kappa;B and mitogen-activated protein kinases, influencing processes such as cell death, inflammation, differentiation, and Wnt signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giorgia Cardinali, Enrica Flori, Arianna Mastrofrancesco, Sarah Mosca, Monica Ottaviani, Maria Lucia Dell'Anna, Mauro Truglio, Antonella Vento, Marco Zaccarini, Christos C. Zouboulis, Mauro Picardo
Summary: Studies have found that the synthetic AhR ligands NPD-0614-13 and NPD-0614-24 show potential in inhibiting inflammatory skin diseases such as psoriasis and atopic dermatitis, with beneficial effects observed in human skin models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael L. Samulevich, Rambon Shamilov, Brian J. Aneskievich
Summary: Intrinsically disordered proteins (IDPs) in keratinocytes, especially those associated with the cornified envelope, demonstrate high levels of intrinsic disorder and potential for liquid-liquid phase separation (LLPS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pa-Fan Hsiao, Yi-Ting Huang, Po-Hsuan Lu, Ling-Ya Chiu, Tzu-Han Weng, Chi-Feng Hung, Nan-Lin Wu
Summary: This study investigates the expression and regulation of TXNIP in psoriasis, as well as its role in skin keratinocyte differentiation and EGFR signaling.
Article
Oncology
Corinna Haist, Zoe Poschinski, Arthur Bister, Michele J. Hoffmann, Camilla M. Grunewald, Alexandra Hamacher, Matthias Kassack, Constanze Wiek, Kathrin Scheckenbach, Helmut Hanenberg
Summary: The study successfully generated a high-affinity EGFR CAR construct and demonstrated its efficacy and specificity in combating head and neck squamous cell carcinoma and other solid cancers.
Article
Multidisciplinary Sciences
Yosuke Harada, Tomohisa Sujino, Kentaro Miyamoto, Ena Nomura, Yusuke Yoshimatsu, Shun Tanemoto, Satoko Umeda, Keiko Ono, Yohei Mikami, Nobuhiro Nakamoto, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Tuneo Ikenoue, Atsushi Hirao, Yoshiaki Kubota, Takanori Kanai
Summary: This study revealed the metabolic properties of intestinal intraepithelial lymphocytes (IELs) and found that the intraepithelial compartment becomes hypoxic in the presence of microbes. Induced CD4(+)CD8 alpha alpha+TCR beta(+) T cells (DPIELs) increase in this location and have lower oxygen and glucose consumption, as well as unique alterations in mitochondria.
Article
Cell & Tissue Engineering
Songjiao Zhao, Xichen Wan, Yiqin Dai, Lan Gong, Qihua Le
Summary: This study found that WNT16B enhances the proliferation and self-renewal of LECs through the CXCR4/MEK/ERK signaling pathway and promotes corneal epithelial wound healing.
Article
Cell Biology
Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park
Summary: This study investigates the biological effects of exogenous NP and NDS, widely used as topical ceramide agents, on cultured human keratinocytes. NDS serves as a precursor for diverse ceramide species required for the permeability barrier and enhances differentiation and innate immunity, while NP does not have the same effects.
Article
Multidisciplinary Sciences
Katherine A. Freitas, Julia A. Belk, Elena Sotillo, Patrick J. Quinn, Maria C. Ramello, Meena Malipatlolla, Bence Daniel, Katalin Sandor, Dorota Klysz, Jeremy Bjelajac, Peng Xu, Kylie A. Burdsall, Victor Tieu, Vandon T. Duong, Micah G. Donovan, Evan W. Weber, Howard Y. Chang, Robbie G. Majzner, Joaquin M. Espinosa, Ansuman T. Satpathy, Crystal L. Mackall
Summary: This research identified MED12 and CCNC as key genes controlling T cell function through CRISPR knockout screening. Knockout of MED12 gene enhances antitumor activity, prolongs the effector phenotype of CAR-T and TCR-T cells, and promotes the expansion of non-engineered T cells. The study reveals the importance of Mediator in T cell effector programming and provides a new target to enhance the potency of antitumor T cell responses.
Article
Biology
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Kohei Yuyama, Daisuke Mikami, Katsuyuki Mukai, Yasuyuki Igarashi
Summary: Konjac ceramide (kCer) has effects on cell migration and differentiation in HaCaT keratinocytes, mediated by cascade crosstalk between Nrp1 and histamine-GPCR pathways.
Article
Dermatology
Huiting Liu, Biying Qiu, Huan Yang, Wen Zheng, Yingying Luo, Yadan Zhong, Ping Lu, Junyi Chen, Ying Luo, Jun Liu, Bin Yang
Summary: In this study, it was found that AHNAK peptide fragments were enriched in the lesions of PLCA patients, and OSMR mutations led to the elevated expression of AHNAK, which resulted in hyperproliferation and overdifferentiation of keratinocytes. This discovery might provide potential therapeutic targets for PLCA.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Review
Immunology
Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch
Summary: TCR signaling plays a crucial role in the development of T cells and the formation of self-reactive T cells, particularly in type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ahmed T. El-Serafi, Ibrahim El-Serafi, Ingrid Steinvall, Folke Sjoberg, Moustafa Elmasry
Summary: Cell regenerative therapy is a modern solution for difficult-to-heal wounds, and the secretions of keratinocytes play an important role in the differentiation of stem cells into keratinocytes. This systematic review found that keratinocyte secretions mainly include cytokines, growth factors, and antimicrobial peptides. Among them, growth factors, especially epidermal growth factor and members of the transforming growth factor family, have a significant impact on the differentiation process. However, most studies focused on the interaction between keratinocytes and inflammation, indicating the need for further research on the nature and regenerative capacities of keratinocyte secretions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Kaixuan Ren, Yumin Xia
Summary: Lipocalin 2 plays a crucial role in the pathogenesis of psoriatic inflammation by exerting versatile effects on skin resident cells and infiltrating immune cells. Neutralizing lipocalin 2 or relevant cytokines can alleviate psoriasis, highlighting lipocalin 2 as an effective interfering target.
JOURNAL OF INFLAMMATION RESEARCH
(2022)