High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Interaction between Rad9–Hus1–Rad1 and TopBP1 activates ATR–ATRIP and promotes TopBP1 recruitment to sites of UV-damage

(2014) Eiji Ohashi et al.   DNA REPAIR

The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage

(2014) Dorthe H. Larsen et al.   NATURE CELL BIOLOGY

Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy

(2013) Nikolina Vlatković et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Akt Switches TopBP1 Function from Checkpoint Activation to Transcriptional Regulation through Phosphoserine Binding-Mediated Oligomerization

(2013) K. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)

(2011) Laura A. Lindsey-Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation

(2011) Henna M. Moore et al.   MOLECULAR & CELLULAR PROTEOMICS

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy

(2010) Meng Ling Choong et al.   CELL CYCLE

Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks

(2010) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer

(2009) K. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA

(2009) J.-H. Choi et al.   NUCLEIC ACIDS RESEARCH

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

(2008) Steffi Herold et al.   EMBO JOURNAL

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

ATR signaling can drive cells into senescence in the absence of DNA breaks

(2008) L. I. Toledo et al.   GENES & DEVELOPMENT

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY