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Plasma platelet activation markers in patients with atopic dermatitis and concomitant allergic diseases

JOURNAL OF DERMATOLOGICAL SCIENCE (2011)

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JOURNAL OF DERMATOLOGICAL SCIENCE

卷 64, 期 1, 页码 79-82

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ELSEVIER IRELAND LTD

DOI: 10.1016/j.jdermsci.2011.07.001

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Dermatology

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Increased plasma miR-24 and miR-191 levels in patients with severe atopic dermatitis: Possible involvement of platelet activation

Misato Maeno, Risa Tamagawa-Mineoka, Yukiyasu Arakawa, Hiromi Nishigaki, Risa Yasuike, Koji Masuda, Norito Katoh

Summary: miR-24 and miR-191 may be involved in the pathomechanisms responsible for the worsening of AD, possibly through their effects on platelet activation.

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Neuroimmune interactions in atopic and allergic contact dermatitis

Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan

Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.

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Latest Progresses in Allergic Diseases Biomarkers: Asthma and Atopic Dermatitis

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Summary: The understanding of the pathologic mechanisms of asthma and atopic dermatitis has improved in recent years. However, the high heterogeneity of both diseases complicates diagnosis and treatment, with current strategies mainly focusing on symptom control rather than full healing. There is a need for more personalized approaches to improve diagnosis and treatment efficacy.

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Transient receptor potential vanilloid 3 expression is increased in non-lesional skin of atopic dermatitis patients

Nikolett Vasas, Zsofia Penzes, Kornel Kistamas, Peter Pal Nanasi, Szabolcs Molnar, Andrea Szegedi, Attila Gabor Szollosi, Tamas Biro

Summary: TRPV3, a pro-inflammatory ion channel, is significantly upregulated in the skin of atopic dermatitis patients. This study provides the first evidence of TRPV3 expression and function in non-lesional AD skin.

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Acceptance of oclacitinib maleate (Apoquel®) chewable tablets in client-owned dogs with allergic and atopic dermatitis

Marike Visser, Kelly Walsh, Vickie King, Gordon Sture, Laura Caneva

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Possible clinical efficacy and tolerability of platelet-rich plasma with atopic dermatitis

Ayman Yosef, Nada Elkady, Fathia Khattab

Summary: The combination of PRP injection with NB-UVB treatment can significantly improve clinical symptoms in patients with atopic dermatitis, shorten the treatment period, and increase patient compliance.

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Atopic Dermatitis-like Genodermatosis: Disease Diagnosis and Management

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Treatment complexity and caregiver burden are linked in owners of dogs with allergic/atopic dermatitis

Mary Beth Spitznagel, Andrew Hillier, Margaret Gober, Mark D. Carlson

Summary: The study shows that caregiver burden is associated with treatment plan complexity and disease severity in owners of dogs with atopic or other chronic allergic dermatitis. The relationship is independent of skin disease severity, highlighting the importance of simplicity in effective treatment planning.

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Beatrice Hanusch, Kathrin Sinningen, Folke Brinkmann, Stefanie Dillenhoefer, Mirjam Frank, Karl-Heinz Joeckel, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Christian Langrock, Thomas Reinehr, Patricia Maasjosthusmann, Bibiana Beckmann, Eckard Hamelmann, Dimitrios Tsikas, Thomas Luecke

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Emergency room visits for childhood atopic dermatitis are associated with floods?

Nai-Tzu Chen, Mu-Jean Chen, Chi-Da Wu, Yue Leon Guo

Summary: This retrospective population-based study in Taiwan found that floods were associated with an increase in emergency room visits for childhood atopic dermatitis (AD). The effects were most notable during the week of the flood, highlighting the importance for healthcare workers to be prepared for potential increases in AD flare-ups following flood events.

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Article Dermatology

Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: A multicenter retrospective case-control study

Hadley Johnson, Marcella R. Aquino, Alan Snyder, Reid W. Collis, Katlein Franca, Alina Goldenberg, Jennifer Y. Sui, Dawn Z. Eichenfield, Brittany J. Kozy, Jennifer K. Chen, Chelsea Shope, Ari M. Goldminz, JiaDe Yu

Summary: Children with atopic dermatitis are more likely to have allergic contact dermatitis and should undergo evaluation and patch testing for allergic contact dermatitis.

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Cascade of atopic dermatitis comorbidities in children after birth for 15 years

Ju Hee Kim, Eun Lee, Eun Kyo Ha, Jeewon Shin, Gi Chun Lee, Yeong Ho Rha, Man Yong Han

Summary: This study used national health insurance data to track individuals born in Korea between 2002 and 2003 and found that atopic dermatitis in children can lead to other diseases. The study identified 20 diseases that are associated with a higher risk of atopic dermatitis, and revealed a temporal sequence of interconnected comorbidities, starting with febrile seizures, constipation, and asthma in childhood and progressing to food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.

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Dupilumab effectiveness for the treatment of patients with concomitant atopic dermatitis and chronic rhinosinusitis with nasal polyposis

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Summary: Atopic dermatitis is a common inflammatory skin disorder affecting up to 20% of children worldwide, with patients commonly experiencing dry skin and itchiness and an increased risk for asthma and allergic rhinitis. The prevalence of AD has tripled in industrial countries over the past 30 years, prompting further investigation into the pathogenesis mechanisms amidst environmental exposures. Studies have identified a role for epigenetic regulation associated with AD and potential drivers for AD pathogenesis.

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Editorial Material Biochemistry & Molecular Biology

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Plasma platelet activation markers in patients with atopic dermatitis and concomitant allergic diseases

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ELSEVIER IRELAND LTD

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