Review
Biochemistry & Molecular Biology
Wei-Chen Chien, Tsen-Fang Tsai
Summary: This article explores the pathological effects of mechanical pressure on the skin from a cellular perspective, highlighting the response and functionality of different cells, as well as the pathological changes induced by mechanical pressure. Investigating mechanotransduction and mechanoresponsive pathways is crucial for diagnosing and managing dermatological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Geonhee Han, Hyosuk Kim, Da Eun Kim, Yeonjoo Ahn, Joongsoo Kim, Ye Ji Jang, Kwangmeyung Kim, Yoosoo Yang, Sun Hwa Kim
Summary: This study found that bovine colostrum-derived exosomes have potential beneficial effects on UV-induced aging and damage. They can prevent the generation of reactive oxygen species in keratinocytes, reduce melanin production in melanocytes, and enhance collagen production in fibroblasts.
Review
Biochemistry & Molecular Biology
Hugo Moreiras, Miguel C. Seabra, Duarte C. Barral
Summary: Several models have been proposed to explain the transfer of melanin in the skin epidermis, with recent observations supporting exo/phagocytosis and shed vesicles models. Limited knowledge about melanin processing within keratinocytes suggests that different mechanisms may co-exist to sustain skin pigmentation. Addressing new questions in understanding basal skin pigmentation could lead to new strategies for treating pigmentary disorders and have cosmetic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ahmed T. El-Serafi, Ibrahim El-Serafi, Ingrid Steinvall, Folke Sjoberg, Moustafa Elmasry
Summary: Cell regenerative therapy is a modern solution for difficult-to-heal wounds, and the secretions of keratinocytes play an important role in the differentiation of stem cells into keratinocytes. This systematic review found that keratinocyte secretions mainly include cytokines, growth factors, and antimicrobial peptides. Among them, growth factors, especially epidermal growth factor and members of the transforming growth factor family, have a significant impact on the differentiation process. However, most studies focused on the interaction between keratinocytes and inflammation, indicating the need for further research on the nature and regenerative capacities of keratinocyte secretions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Vitor Helio de Souza Oliveira, Mayara Alves Amorim, Janiana Raiza Jentsch Matias de Oliveira, Bruna Silva Soley, Fernanda Grillo Rocha, Margareth de Mello Bandenburg, Vanessa Bordenowsky Pereira Lejeune, Alvaro Henrique Bernardo de Lima Silva, Deborah A. Witherden, Wendy L. Havran, Janaina Menezes Zanoveli, Daniela Almeida Cabrini, Joao Batista Calixto, Michel Fleith Otuki, Eunice Andre
Summary: The study aimed to determine the potential topical anti-inflammatory and antiproliferative effects of baclofen cream in an inflammatory skin disease model. The results demonstrate that baclofen exhibits notable topical antiproliferative and anti-inflammatory properties, making it a potential therapeutic alternative for treating inflammatory and proliferative skin diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Qinyue Xie, Jianhong Yang, Feifei Pan, Jun Cai
Summary: This study evaluated the wound healing performance of 6-carboxyl chitin, which was found to promote the proliferation of human skin fibroblasts and keratinocytes depending on concentration and molecular weight. The optimal conditions observed were 10-40 kDa and 10-100 μg/mL for fibroblast proliferation, while keratinocyte proliferation increased with lower concentration and molecular weight. Additionally, 6-carboxyl chitins were able to induce the secretion of growth factors by macrophages and fibroblasts, indicating potential as an active ingredient for wound healing.
CARBOHYDRATE POLYMERS
(2021)
Article
Dermatology
Alec Sevilla, Jeremy Cheret, Wendy Lee, Ralf Paus
Summary: This pilot study aimed to investigate the effects of melatonin on melanin production and melanocytes in intact human epidermis. The results showed that melanin content and melanocyte dendricity increased with melatonin treatment, while tyrosinase activity was inhibited. Higher doses of melatonin increased the number and proliferation of melanocytes and keratinocytes, as well as the expression of the premelanosomal marker gp100. These findings suggest that long-term melatonin therapy may stimulate melanogenesis and increase the activity of epidermal melanocytes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Seoyeon Lee, Luye An, Paul D. Soloway, Andrew C. White
Summary: This study identified three different cell states of melanocytes - quiescent melanocyte stem cells, activated melanocyte stem cells, and differentiated melanocytes - through analyzing melanocyte nuclei of mice. The study also revealed potential gene regulators for these cell states and provided an online tool for further research on melanocyte stem cell regulation upon natural or UVB-mediated activation.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Review
Anatomy & Morphology
Kimihiko Sugaya
Summary: This review investigated the changes in skin characteristics caused by aging in mice and their correlation with keratinocyte and melanocyte stem cells. The study aimed to analyze these changes throughout the mouse lifetime. It was found that curved hair follicles and white hairs were considered as biomarkers of aging in mice, and the low number of tyrosinase-related protein 2-positive melanocyte stem cells may contribute to the induction of melanocyte and keratinocyte-derived characteristics by aging.
CELLS TISSUES ORGANS
(2023)
Review
Biochemistry & Molecular Biology
Maria Pia Polito, Grazia Marini, Michele Palamenghi, Elena Enzo
Summary: The epidermis is a protective tissue in the human body, consisting of proliferative basal cells and differentiating suprabasal layers. Understanding the molecular mechanisms and pathways involved in keratinocytes' organization and regeneration is crucial for therapeutic approaches. Single-cell techniques have identified disease-specific drivers and therapeutic targets, advancing personalized therapies. This review summarizes the latest findings on transcriptomic and epigenetic profiling of human epidermal cells under different skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Asako Yamamoto, Lingli Yang, Yasutaka Kuroda, Jiao Guo, Lanting Teng, Daisuke Tsuruta, Ichiro Katayama
Summary: The skin, as the outermost barrier of the body, is a major target of oxidative stress. Local synthesis of estrogen in the skin to protect from oxidative stress has been explored, with abnormal local estrogen synthesis potentially involved in skin disorders. The findings suggest potential new intervention targets for combination therapy for conditions such as vitiligo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Marit H. Aure, Jennifer M. Symonds, Carlos U. Villapudua, Joshua T. Dodge, Sabine Werner, Wendy M. Knosp, Matthew P. Hoffman
Summary: The study reveals the crucial role of FGFR2 in salivary gland development and differentiation, specifically in seromucous acinar cells. Additionally, the findings suggest that MEC-derived FGF7 activates FGFR2 signaling to drive acinar differentiation.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yo Oguma, Yasumasa Kuroda, Shohei Wakao, Yoshihiro Kushida, Mari Dezawa
Summary: In human bone marrow-mesenchymal stromal cells, the pluripotent-like Muse-MSCs and multipotent MSCs show differential gene expression patterns, with Muse-MSCs exhibiting higher expression of genes related to signal acceptance, metabolism, and ribosomes, and MSCs showing higher expression of genes related to cell cycle, cytoskeleton, and extracellular matrix.
