期刊
JOURNAL OF DENTAL RESEARCH
卷 92, 期 6, 页码 553-559出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034513487558
关键词
alveolar bone loss; osteogenesis; inflammation; wounds and injuries; bone remodeling; connective tissue
资金
- ICOI Implant Dentistry Research and Education Foundation
- Delta Dental Foundation
- NIDCR award from the National Institutes of Health [DE022327]
- Grants-in-Aid for Scientific Research [25870523] Funding Source: KAKEN
Intermittent parathyroid hormone (PTH) administration increases systemic and craniofacial bone mass. However, the effect of PTH therapy on healing of tooth extraction sites is unknown. The aims of this study were to determine the effect of PTH therapy on tooth extraction socket healing and to examine whether PTH intra-oral injection promotes healing. The mandibular first molars were extracted in rats, and subcutaneous PTH was administered intermittently for 7, 14, and 28 days. In a second study, maxillary second molars were extracted, and PTH was administered by either subcutaneous or intra-oral injection to determine the efficacy of intra-oral PTH administration. Healing was assessed by micro-computed tomography and histomorphometric analyses. PTH therapy accelerated the entire healing process and promoted both hard-and soft-tissue healing by increasing bone fill and connective tissue maturation. PTH therapy by intra-oral injection was as effective as subcutaneous injection in promoting tooth extraction socket healing. The findings suggest that PTH therapy promotes tooth extraction socket healing and that intra-oral injections can be used to administer PTH.
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