Article
Engineering, Biomedical
Danni Dai, Jianrong Wang, Hanshu Xie, Chao Zhang
Summary: In this study, a functional nanocomposite of epigallocatechin gallate (EGCG) and amorphous calcium phosphate (ACP) was developed for the prevention and restoration of demineralization. The EGCG-ACP exhibited good biocompatibility and showed sustained release of ACP to restore the microstructure and mechanical properties of demineralized enamel under neutral conditions. Under acidic conditions, protonated EGCG exerted a strong antibacterial effect, preventing demineralization in the presence of cariogenic bacteria. The pH-responsive features of EGCG-ACP facilitated its performance in remineralization to overcome the difficulty of restoring demineralized enamel in a cariogenic acidic environment.
MATERIALS TODAY BIO
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nayara Goncalves Emerenciano, Alberto Carlos Botazzo Delbem, Francyenne Maira Castro Goncalves, Julia Paiao Quinterio, Emerson Rodrigues de Camargo, Yara Teresinha Correa Silva-Sousa, Marcelle Danelon
Summary: The addition of 0.25% nano-sized beta-CaGPn to 1100F formulation increased the bioavailability of calcium and phosphate, promoting a higher level of remineralization.
JOURNAL OF DENTISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Jiarong Yan, Hongye Yang, Ting Luo, Fang Hua, Hong He
Summary: Enamel demineralization, a common dental problem, is a concern for dental professionals and patients due to its impact on both health and aesthetics. Amorphous calcium phosphate (ACP) has gained attention as a potential agent for preventing or treating enamel demineralization. This article briefly reviews ACP stabilizers and their mechanisms, as well as the scientific evidence supporting the remineralization ability of these agents. The limitations of current research and future prospects for clinical translation of ACP agents are also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Camila A. Zamperini, Ana K. Bedran-Russo
Summary: The aim of this study was to determine the immediate and sustained effect of fluoride varnish and its combinations with toothpastes in preventing root caries development. The study found that all prevention protocols significantly decreased dentin porosity and increased mineral density. The combination of fluoride varnish with toothpaste showed superior anti-caries effects.
Article
Dentistry, Oral Surgery & Medicine
Mauro A. Tudares, George J. Eckert, Frank Lippert
Summary: This study investigates the effects of 5% sodium fluoride varnish and 38% silver diamine fluoride on preventing demineralization of human enamel lesions of different severities. The results suggest that silver diamine fluoride may have comparable benefits to fluoride varnish in preventing mineral loss.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Seok-Min Choi, Hee-Won Jung, Ji Hyun Ryu, Hyung-Keun You
Summary: This study evaluated the remineralization of tooth enamel using one-pot coating with polydopamine and fluoride ions. The results showed that enamel coated with polydopamine and fluoride ions had the highest fluoride content and the lowest reduction in hardness. Scanning electron microscopy further supported the effect of the coating on enamel remineralization.
Article
Chemistry, Physical
Markus Reise, Stefan Kranz, Markus Heyder, Klaus D. Jandt, Bernd W. Sigusch
Summary: This study evaluated the effectiveness of Tooth Mousse compared to conventional fluoride-based versions in preventing enamel and dentin demineralization. Results showed that Tooth Mousse was less effective in preventing demineralization compared to fluoride toothpastes, but using Tooth Mousse during demineralization led to a reduced number of severe lesions.
Article
Nanoscience & Nanotechnology
Youna Paik, Min Joo Kim, Hyeryeong Kim, Sun-Woo Kang, Youn-Kyung Choi, Yong-Il Kim
Summary: The study aimed to evaluate the remineralization effect of calcium phosphate ion clusters (CPICs) on demineralized enamel surfaces and their effects on bracket shear bond strength. The results showed that CPIC treatment led to epitaxial growth of enamel, a decrease in demineralized enamel thickness, an increase in Ca/P ratio, and an improvement in microhardness. The radiolucency gradually decreased with longer CPIC treatment. The shear bond strength and adhesive remnant index results indicated improved bonding stability after CPIC treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Spectroscopy
Merve Atas Demir, Ebru Hazar Bodrumlu, Levent Demiriz
Summary: This study aimed to evaluate the changes in PO4-3 of enamel surfaces by using Raman analysis after applying three different remineralization agents containing Ca-PO4-3 in vitro. The study found that remineralizing agents have positive effects on the phosphate concentration of initial enamel caries, but there was no significant difference in PO4-3 changes between remineralized surfaces and intact surfaces.
JOURNAL OF RAMAN SPECTROSCOPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Francyenne Maira Castro Goncalves, Alberto Carlos Botazzo Delbem, Leonardo Fernandes Gomes, Nayara Goncalves Emerenciano, Juliano Pelim Pessan, Giovana Dornelas Azevedo Romero, Mark L. Cannon, Marcelle Danelon
Summary: The study demonstrated that the combination treatment of 1100 F-TMP and MI Paste Plus (R) had the best effect on enamel remineralization, significantly increasing subsurface hardness and promoting an increase in calcium and phosphorus concentrations.
ARCHIVES OF ORAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Jiarong Xu, Hui Shi, Jun Luo, Haiyan Yao, Pei Wang, Zhihua Li, Junchao Wei
Summary: This article discusses the importance of enamel remineralization and the application of advanced materials, pointing out that remineralization treatment can effectively control the progression of caries and restore the structure and hardness of the enamel.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiankang He, Jianhai Yang, Min Li, Yachong Li, Yanyun Pang, Jiayin Deng, Xu Zhang, Wenguang Liu
Summary: This study developed a dual-functional nanocomposite with antibiofilm and remineralization properties, composed of zwitterionic poly(carboxybetaine acrylamide) and amorphous calcium phosphate. The nanocomposite exhibited significant inhibitory effects on bacterial adhesion and biofilm formation, and demonstrated bactericidal activities under acidic conditions. Furthermore, it showed better effects in promoting dental caries treatment compared to fluoride.
Article
Biochemistry & Molecular Biology
Hani M. Nassar, Frank Lippert
Summary: This study investigated artificial caries lesion characteristics after secondary demineralization with different levels of fluoride and theobromine. The results showed that fluoride-containing groups had significantly deeper lesions, while theobromine did not have an additional effect on mineral uptake.
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Article
Multidisciplinary Sciences
James R. Fernando, Glenn D. Walker, Thomas Kwan-Soo Park, Peiyan Shen, Yi Yuan, Coralie Reynolds, Eric C. Reynolds
Summary: Assessment of enamel subsurface lesion remineralisation is crucial for evaluating novel remineralisation technologies. This study compared the efficacy of transverse microradiography (TMR) and surface microhardness (SMH) in assessing enamel remineralisation after treatment with calcium-containing technologies. Results showed that the parameters obtained from TMR and SMH analyses were not significantly correlated, suggesting that TMR is a more appropriate method for evaluating enamel subsurface remineralisation. The study also found a significant correlation between TMR measurements and the water-soluble calcium concentration of the remineralisation products.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bashayer H. Baras, Jirun Sun, Mary Anne S. Melo, Franklin R. Tay, Thomas W. Oates, Ke Zhang, Michael D. Weir, Hockin H. K. Xu
Article
Materials Science, Biomaterials
Yang Xia, Yu Guo, Zukun Yang, Huimin Chen, Ke Ren, Michael D. Weir, Laurence C. Chow, Mark A. Reynolds, Feimin Zhang, Ning Gu, Hockin H. K. Xu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Hong Chen, Yunhao Tang, Michael D. Weir, Jianghong Gao, Satoshi Imazato, Thomas W. Oates, Lei Lei, Suping Wang, Tao Hu, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Wen Zhou, Xian Peng, Xuedong Zhou, Michael D. Weir, Mary Anne S. Melo, Franklin R. Tay, Satoshi Imazato, Thomas W. Oates, Lei Cheng, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Xiuzhi Fei, Yuncong Li, Michael D. Weir, Bashayer H. Baras, Haohao Wang, Suping Wang, Jirun Sun, Mary A. S. Melo, Jianping Ruan, Hockin H. K. Xu
Article
Engineering, Biomedical
Yoontae Kim, Eun-Jin Lee, Albert Davydov, Stanislav Frukhtbeyen, Jonathan E. Seppala, Shozo Takagi, Laurence Chow, Stella Alimperti
Summary: Biofabrication has been utilized to engineer patient-specific biosynthetic grafts for bone regeneration, with a new 3D printing approach developed in this study using calcium phosphate cement (CPC) and non-aqueous CPC bioinks. The choice of PVB solvents, EtOH or THF, was found to affect the rheological properties, microstructure, mechanical properties, and osteoconductivity of the scaffolds. This novel method opens up possibilities for engineering high-resolution, implantable, and osteoconductive scaffolds with predetermined properties for bone regeneration.
BIOMEDICAL MATERIALS
(2021)
Article
Cell & Tissue Engineering
Gengtao Qiu, Mingguang Huang, Jin Liu, Ping Wang, Abraham Schneider, Ke Ren, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu, Liang Zhao
Summary: The novel CPCC + DOX scaffold demonstrated excellent mechanical properties and strong antibacterial activity, while also supporting proliferation and osteogenic differentiation of hPDLSCs. This scaffold has the potential to enhance bone regeneration and combat bone infections in dental, craniofacial, and orthopedic applications.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Heba Mitwalli, Rashed AlSahafi, Ebtehal G. Albeshir, Quan Dai, Jirun Sun, Thomas W. Oates, Mary Anne S. Melo, Hockin H. K. Xu, Michael D. Weir
Summary: The study developed a new bioactive nanocomposite with antibacterial and remineralizing properties by incorporating DMAHDM and nCaF2. The composites demonstrated good mechanical properties, potent antibacterial activity against biofilms, and high F and Ca ion releases, showing potential for preventing caries.
JOURNAL OF DENTISTRY
(2021)
Article
Engineering, Biomedical
Christopher J. Panebianco, Sanjna Rao, Warren W. Hom, James H. Meyers, Tiffany Y. Lim, Damien M. Laudier, Andrew C. Hecht, Michael D. Weir, Jennifer R. Weiser, James C. Iatridis
Summary: This study developed an injectable composite biomaterial using degradable oxidized alginate microbeads for delivering annulus fibrosus cells to injured intervertebral discs. The composite material achieved a balance between biomechanical and biological demands, providing promising results for cell delivery and repair.
Article
Dentistry, Oral Surgery & Medicine
Rashed AlSahafi, Heba Mitwalli, Abdullah Alhussein, Mary Anne S. Melo, Frederico Martinho, Christopher D. Lynch, Thomas W. Oates, Hockin H. K. Xu, Michael D. Weir
Summary: This study investigated the efficacy of a novel resin cement containing DMAHDM and NACP in inhibiting saliva microcosm biofilm. The results showed that the cement exhibited strong antibacterial action and continuous ion release, indicating its potential for remineralization.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hanan Filemban, Ghalia Bhadila, Xiaohong Wang, Mary Ann S. Melo, Thomas W. Oates, Gary D. Hack, Christopher D. Lynch, Michael D. Weir, Jirun Sun, Hockin H. K. Xu
Summary: This study developed a bioactive low-shrinkage-stress composite with antibacterial and remineralizing properties. After thermal cycling, the composite demonstrated good mechanical properties and maintained its strong antibacterial activity. This material shows great potential in inhibiting recurrent caries and increasing restoration longevity.
JOURNAL OF DENTISTRY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ghalia Y. Bhadila, Bashayer H. Baras, Abdulrahman A. Balhaddad, Mary Ann Williams, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu
Summary: This study reviewed different recurrent caries models used to evaluate restorative materials and compared their methodology and parameters. Specific recommendations for future investigations were also provided.
JOURNAL OF DENTISTRY
(2023)
Article
Engineering, Biomedical
Michael D. Weir, Papatya Kaner, Alexander Marin, Alexander K. Andrianov
Summary: The study used novel polyphosphazenes to modify tooth surfaces, improving the stability of the bonded interface between composite restorations and teeth. Results showed significant and stable adsorption of polyphosphazenes onto teeth, potentially leading to a more stable bonded interface.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Michael D. Weir, Jianping Ruan, Ning Zhang, Laurence C. Chow, Ke Zhang, Xiaofeng Chang, Yuxing Bai, Hockin H. K. Xu
