期刊
JOURNAL OF DENTAL RESEARCH
卷 91, 期 6, 页码 598-604出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034512444128
关键词
antibacterial dentin primer; quaternary ammonium salt; dental biomaterials; bond strength; dental plaque microcosm biofilm; caries inhibition
资金
- China National Science Foundation [81100745]
- School of Stomatology of Capital Medical University in China
- Coordination for Improvement of Higher Education CAPES/Fulbright [0523/11-9]
- NIH [R01DE17974, R01DE14190]
- University of Maryland School of Dentistry
Antibacterial bonding agents could combat recurrent caries at the tooth-composite margins. The objectives of this study were to develop novel antibacterial dentin primers containing quaternary ammonium dimethacrylate (QADM) and nanoparticles of silver (NAg), and to investigate the effects on dentin bond strength and dental plaque microcosm biofilms for the first time. Scotchbond Multi-Purpose (SBMP) bonding agent was used. QADM and NAg were incorporated into SBMP primer, yielding 4 primers: SBMP primer (control), control + 10% QADM (mass), control + 0.05% NAg, and control + 10% QADM + 0.05% NAg. Human saliva was collected to grow microcosm biofilms. The NAg particle size (mean +/- SD; n = 100) was 2.7 +/- 0.6 nm. Dentin shear bond strengths (n = 10) with human third molars were approximately 30 MPa for all groups (p > 0.1). QADM-NAg-containing primer increased the bacteria inhibition zone by 9-fold, compared with control primer (p < 0.05). QADM-NAg-containing primer reduced lactic acid production and colony-forming units of total micro-organisms, total streptococci, and mutans streptococci by an order of magnitude. In conclusion, novel QADM-NAg-containing primers were strongly antibacterial without compromising dentin bond strength, and hence are promising to inhibit biofilms and secondary caries. The processing method of incorporating QADM and NAg together into the same primer produced the strongest antibacterial effect, which could have a wide applicability to other bonding systems.
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