Article
Oncology
Ke Wang, Hua-Yang Fan, Xing Pang, Mei Zhang, Xiang-Hua Yu, Jia-Shun Wu, Bing-Jun Chen, Jian Jiang, Xin-Hua Liang, Ya-Ling Tang
Summary: High expression of Dll4 is associated with invasive front of SACC, solid tumor type, high TNM grade, and high metastasis and recurrence rates. Notch1 and Dll4 are positively correlated at the invasive front, with leader cells showing high Dll4 expression and follower cells showing high Notch1 expression in a 3D culture model. Silencing Dll4 reduces migration and invasion of SACC cells, but overexpression of Notch1 can rescue these abilities. Dll4/Notch1 signaling pathway may play a role in collective invasion of SACC and could be a potential target for SACC treatment.
Article
Biochemistry & Molecular Biology
Zichang Dai, Qiyuan Huang, Xueran Huang, Chuiyu Zhu, Kashif Rafiq Zahid, Tiancai Liu, Qiuyan Li, Chunmei Wu, Minghui Peng, Xiangyan Xiao, Umar Raza, Nan Yu, Tao Zeng
Summary: The expression of KIN17 is significantly increased in HCC and is associated with tumor progression and metastasis. KIN17 promotes migration and invasion of HCC cells by stimulating the TGF-beta/Smad2 pathway. It could serve as a potential therapeutic target and prognostic biomarker in HCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Endocrinology & Metabolism
Jie Xu, Na Xiao, Hailang He, Ailing Cao, Xianmei Zhou
Summary: The study aimed to investigate the action and mechanism of Asperuloside on non-small cell lung cancer (NSCLC). The results showed that Asperuloside significantly suppressed the proliferation, invasion, and migration abilities of NSCLC cells, promoted apoptosis, and reduced tumor size and weight in mice. Moreover, Asperuloside inhibited the TGF-β1/Smad2 pathway, resulting in down-regulation of N-Cadherin and Vimentin protein levels and up-regulation of E-Cadherin protein level.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Mei Zhang, Jia-Shun Wu, Hong-Chun Xian, Bing-Jun Chen, Hao-Fan Wang, Xiang-Hua Yu, Xin Pang, Li Dai, Jian Jiang, Xin-Hua Liang, Ya-Ling Tang
Summary: Our study confirmed the role of CXCR5 in SACC, facilitating PNI by downregulating miR-187 to disinhibit S100A4 expression.
Review
Oncology
Sosuke Sahara, Alexandra E. Herzog, Jacques E. Nor
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer with no standard chemotherapy currently available. Response rates to cytotoxic agents are around 10%, while combination therapies like CAP and cisplatin-vinorelbine have response rates of 18-31%. Inhibitors targeting VEGFR show relatively high response rates of 11-17%. Targeting cancer stem cells (CSC), drivers of chemoresistance and recurrence, could lead to valuable therapies for ACC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Carlos A. Rodriguez-Russo, Jacqueline C. Junn, Sue S. Yom, Richard L. Bakst
Summary: Adenoid cystic carcinoma (ACC) is a rare malignancy in the head and neck region with a high propensity for perineural invasion, often necessitating a balance between disease burden and treatment morbidity. Radiotherapy plays a crucial role in improving local control and managing unresectable disease, particularly in cases of perineural invasion. Target delineation and treatment regimens in different settings, including definitive, recurrent, and metastatic disease, are important considerations in the management of ACC.
Article
Oncology
Jun Wang, Zihui Yang, Yuanyang Liu, Huan Li, Xiangming Yang, Wanpeng Gao, Qi Zhao, Xinjie Yang, Jianhua Wei
Summary: This study investigates the role and molecular mechanisms of the neuropeptide GAL and its receptor GALR2 in the regulation of perineural invasion (PNI) in salivary adenoid cystic carcinoma (SACC). The results show that GAL and GALR2 are highly expressed in SACC tissues and are associated with PNI and poor prognosis in SACC patients. Nerve-derived GAL activates GALR2 expression, promoting epithelial-to-mesenchymal transition (EMT) in SACC cells and enhancing the PNI process. Blocking the GAL/GALR2 axis may be a novel strategy for anti-PNI therapy for SACC.
Article
Oncology
Kentaro Takada, Yoshihiro Aizawa, Daisuke Sano, Ryo Okuda, Keisuke Sekine, Yasuharu Ueno, Shoji Yamanaka, Jun Aoyama, Kaname Sato, Tatsu Kuwahara, Takashi Hatano, Hideaki Takahashi, Yasuhiro Arai, Goshi Nishimura, Hideki Taniguchi, Nobuhiko Oridate
Summary: The study developed new in vitro and in vivo models of adenoid cystic carcinoma (ACC) using organoid culture and patient-derived tumor xenograft (PDX) techniques. Human ACC-derived organoids were successfully generated, providing insights into understanding the biology of ACC and creating personalized therapy design for patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shujuan Yan, Meng Wang
Summary: This study identified the regulatory axis of HCG11/miR-1297/EphA2 in SACC, which may provide novel therapeutic targets for SACC.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Review
Oncology
Fernanda Jardim da Silva, Juscelino Carvalho de Azevedo, Ana Carolina Lima Ralph, Joao de Jesus Viana Pinheiro, Vanessa Morais Freitas, Danielle Queiroz Calcagno
Summary: Adenoid cystic carcinoma (ACC) is an aggressive tumor commonly found in the head and neck region. Surgical resection is the primary treatment, but there is no effective systemic therapy for advanced disease. Molecular alterations involving genes such as MYB, MYBL1, and NFIB, as well as copy number alterations (CNAs), have been identified in ACC. Despite ongoing research, there are currently no FDA-approved systemic therapies for ACC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Renata Ferrarotto, Yoshitsugu Mitani, Daniel J. McGrail, Kaiyi Li, Tatiana Karpinets, Diana Bell, Steven J. Frank, Xingzhi Song, Michael E. Kupferman, Bin Liu, J. Jack Lee, Bonnie S. Glisson, Jianhua Zhang, Jon C. Aster, Shiaw-Yih Lin, P. Andrew Futreal, John Heymach, Adel K. El-Naggar
Summary: Salivary gland adenoid cystic carcinoma (ACC) exhibits heterogeneous clinical behavior and can be classified into two molecular subtypes: ACC-I and ACC-II. ACC-I is characterized by poor prognosis, upregulation of MYC and NOTCH mutations, while ACC-II shows less aggressive clinical course with upregulation of TP63 and receptor tyrosine kinases.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mao Li, Zi-xin Wan, Yue-yang Tang, Xin-hua Liang, Ya-ling Tang
Summary: Immunohistochemical staining was used to detect the expression of TIM-3, Gal-9, and CD160 in SACC and their correlation with clinicopathological characteristics. The results showed that overexpression of TIM-3 and CD160 were associated with SACC recurrence, while high expression of Gal-9 was correlated with pathological classification. The average percentage of TILs in SACC was 18.2%, with a higher occurrence in minor salivary glands. There were positive correlations observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells and TILs. These findings suggest that the density of TILs and the expression of TIM-3, Gal-9, and CD160 could be potential therapeutic targets in SACC.
Article
Cell Biology
Mei Zhang, Min Zheng, Li Dai, Wei-long Zhang, Hua-yang Fan, Xiang-hua Yu, Xin Pang, Peng Liao, Bing-jun Chen, Sha-sha Wang, Ming-xin Cao, Xiang-rui Ma, Xin-hua Liang, Ya-ling Tang
Summary: The study revealed that activation of the CXCL12/CXCR4 axis in SACC may promote perineural invasion (PNI) by inducing tumor cells to differentiate towards Schwann-like cells through the Twist/S100A4 axis, accelerating cancer progression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Qian Jiang, Xing Liu, Qifen Yang, Liang Chen, Deqin Yang
Summary: Microorganisms have been found to be closely linked to the development of cancer in humans. This study compared the salivary microbiome of salivary adenoid cystic carcinoma (SACC) patients and healthy controls, revealing higher abundance of Streptococcus and Rothia in SACC patients and more Prevotella and Alloprevotella in healthy controls. Functional gene analysis identified specific KEGG pathways, carbohydrate-active enzymes, antibiotic resistances, and virulence factors in SACC patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Li Zeng, Jiahui Wei, Dong Han, Haochen Liu, Yang Liu, Na Zhao, Shichen Sun, Yixiang Wang, Hailan Feng
Article
Oncology
Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wang
Article
Medicine, Research & Experimental
Zhongfang Zhao, Ying Han, Zhihui Zhang, Wenwen Li, Xiaoli Ji, Xiaodan Liu, Jianqiu Jin, Si Xu, Hongmei Cui, Zhe Cheng, Qian Wang, Xing Wang, Xiang Guo, Yixiang Wang, Hongwei Liu
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Oncology
Li Zeng, Na Zhao, Fang Li, Dong Han, Yang Liu, Haochen Liu, Shichen Sun, Yixiang Wang, Hailan Feng
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Cell Biology
Li Zeng, Shichen Sun, Dong Han, Yang Liu, Haochen Liu, Hailan Feng, Yixiang Wang
CELLULAR SIGNALLING
(2018)
Article
Dentistry, Oral Surgery & Medicine
Li Zeng, Jiahui Wei, Na Zhao, Shichen Sun, Yixiang Wang, Hailan Feng
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Chemistry, Analytical
Lixing Liu, Beiyuan Fan, Diancan Wang, Xiufeng Li, Yeqing Song, Ting Zhang, Deyong Chen, Yixiang Wang, Junbo Wang, Jian Chen
Article
Pharmacology & Pharmacy
Zewen Han, Qingxiang Li, Yifei Wang, Lin Wang, Xiaoxu Li, Na Ge, Yixiang Wang, Chuanbin Guo
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Oncology
Wenwen Li, Ying Han, Zhongfang Zhao, Xiaoli Ji, Xing Wang, Jianqiu Jin, Qian Wang, Xiang Guo, Zhe Cheng, Mingxing Lu, Guodong Wang, Yixiang Wang, Hongwei Liu
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Cell & Tissue Engineering
Xiaoxia Li, Jing Xie, Yue Zhai, Tengjiaozi Fang, Nanquan Rao, Shuang Hu, Liping Yang, Yuming Zhao, Yixiang Wang, Lihong Ge
STEM CELLS INTERNATIONAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Juan Liu, Yixiang Wang, Huanxin Meng, Jingting Yu, Hongye Lu, Wenjing Li, Ruifang Lu, Yibing Zhao, Qiqiang Li, Li Su
JOURNAL OF CLINICAL PERIODONTOLOGY
(2019)
Article
Cell Biology
Yidi Wang, Yue Liu, Haotian Chen, Xiaojing Liu, Yi Zhang, Yixiang Wang, Yan Gu
Summary: In this study, FGFR2 mutation p.Cys342Arg was found to promote osteogenesis by enhancing mitochondrial metabolism-mediated FGF/FGFR-AMPK-Erk1/2 signaling pathway. This finding suggests the potential of targeting AMPK or Erk1/2 for the treatment of syndromic craniosynostosis.
Article
Cell Biology
Yuejiao Xin, Yang Liu, Jie Li, Dandan Liu, Chenying Zhang, Yixiang Wang, Shuguo Zheng
Summary: This study identified a novel osteoclast-specific lncRNA (OC-lncRNA) in CCD, which positively regulated osteoclastogenesis and bone resorption by competitively binding to miR-221-5p and promoting the expression of CXCR3. These findings uncover the underlying mechanism of OC-lncRNA-mediated osteoclast dysfunction in the delayed tooth eruption of CCD.
Article
Medicine, Research & Experimental
Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wang
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Li Zeng, Na Zhao, Dong Han, Haochen Liu, Yang Liu, Yixiang Wang, Hailan Feng
ARCHIVES OF ORAL BIOLOGY
(2017)
