Review
Oncology
Rosa A. Castillo-Rodriguez, Cristina Trejo-Solis, Alfredo Cabrera-Cano, Saul Gomez-Manzo, Victor Manuel Davila-Borja
Summary: In this review, the association between hypoxia and cancer is analyzed, focusing on the effects of hypoxia on tumoral cells and surrounding cells, as well as the involvement of HIF, NF-kappa B, and STAT signaling pathways. The response of immune cells to hypoxia and potential therapeutic applications are also discussed.
Review
Biochemistry & Molecular Biology
Jan Korbecki, Donata Siminska, Magdalena Gassowska-Dobrowolska, Joanna Listos, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This paper discusses the mechanisms and effects of chronic low-grade inflammation caused by chronic hypoxia and cycling hypoxia in malignant tumors, as well as their impact on the tumor microenvironment and cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Tanja Stachon, Lorenz Latta, Berthold Seitz, Nora Szentmary
Summary: The study investigates the effect of hypoxia through NF-kappa B signaling pathways on iNOS, HIF, ROS, and proliferation of normal and KC human corneal fibroblasts in vitro. Hypoxia increases NF-kappa B and iNOS mRNA expression in normal HCFs, but not in KC-HCFs, possibly due to preexisting oxidative stress. HIF and PHD2 do not show altered iNOS regulation under hypoxic conditions in KC-HCFs, suggesting they may not play a role in keratoconus pathogenesis.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hao Cai, Zhenzhong Bai, Ri-Li Ge
Summary: The study revealed that hypoxia exposure can promote the development of NASH by upregulating HIF-2 alpha, further activating NF-kappa B, exacerbating fibrosis and inflammation, providing a new approach for the treatment of NASH.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Shubham Rastogi, Sara Aldosary, Abdulaziz S. S. Saeedan, Mohd Nazam Ansari, Manjari Singh, Gaurav Kaithwas
Summary: Hypoxia in cancer cells is caused by persistent inflammation and involves the activation of NF-kappa B and HIF-1 alpha. NF-kappa B promotes tumor development and maintenance, while HIF-1 alpha aids cellular proliferation and adaptability to angiogenic signals. The key oxygen-dependent regulator of HIF-1 alpha and NF-kappa B activity is hypothesized to be Prolyl hydroxylase-2 (PHD-2). In non-hypoxic tumor cells, PHD-2 is inactive due to pyruvate-mediated competitive inhibition of 2-oxo-glutarate, leading to the canonical activation of NF-kappa B.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Biochemistry & Molecular Biology
Deborah Fratantonio, Fabio Virgili, Alessandro Zucchi, Kate Lambrechts, Tiziana Latronico, Pierre Lafere, Peter Germonpre, Costantino Balestra
Summary: The study found that exposure to different concentrations of hyperoxia leads to activation of different oxygen-sensitive transcription factor patterns in human peripheral blood mononuclear cells. Mild hyperoxia is perceived as hypoxic stress, leading to activation of HIF-1α and NRF2, while high and very high concentrations of hyperoxia induce an oxidative stress response, characterized by activation of NRF2 and NF-κB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Junfei Cheng, Yuemei Sun, Jiaxin He, Zihan Wang, Wenbin Li, Rong Wang
Summary: The high-altitude environment damages the intestinal mucosal barrier and leads to a high incidence of intestinal diseases, but the mechanism is not well defined. This study found that high altitude causes inflammatory damage to colon tissue and exacerbates intestinal hypoxia. The results highlight that the high-altitude environment reduces the concentration of oxygen in the colonic lumen microenvironment, disrupts the colonic mucosal barrier, and ultimately induces and exacerbates intestinal injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Yunhui Hu, Jia Sun, Tongxing Wang, Hairong Wang, Chunlai Zhao, Wenjia Wang, Kaijing Yan, Xijun Yan, He Sun
Summary: CDDP can protect animals from tissue damage caused by hypobaric hypoxia by improving oxidative stress and inflammation.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vittoria Borgonetti, Nicoletta Galeotti
Summary: Combining HDAC and BET inhibitors can effectively alleviate pain sensitivity in a mouse model of neuropathic pain and inhibit neuroinflammation in the spinal cord. This combination therapy shows potential as a new therapeutic option for targeting neuropathic pain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Pathology
Young San Ko, Jung-Soo Pyo, Won Jin Cho
Summary: The activation of NF-kappa B in BPH is found to be correlated with low total and T-zone volumes in transrectal ultrasonography, but not with HIF-1 alpha expression and microvessel density. Moreover, diffuse fibrosis is frequently observed in patients without NF-kappa B activation and with HIF-1 alpha positivity.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Huahua Tu, Wei Wang, Yanqing Feng, Linfei Zhang, Huadong Zhou, Caitao Cheng, Lei Ji, Qinghe Cai, Yong Feng
Summary: Beta-patchoulene (beta-PAE) is a compound extracted from patchouli with analgesic, anti-inflammatory, and antioxidant effects. This study found that beta-PAE can inhibit the growth, proliferation, migration, and epithelial-mesenchymal transition of hypoxia-induced hepatocellular carcinoma (HCC) cells, and promote apoptosis.
Review
Medicine, General & Internal
Lanxin Hu, Jinwei Hu, Yanlin Huang, Sihan Zheng, Ji Yin, Xiaohui Li, Daiying Li, Caifeng Lv, Sen Li, Wenjian Hu
Summary: Since the 1950s, hypoxia has been identified as a crucial characteristic of cancer cells and their microenvironment, promoting cancer growth, survival, and metastasis. In the early 1990s, the activation of hypoxia-inducible factor-1 alpha (HIF1 alpha) was discovered as a key process in hypoxia, influencing angiogenesis and contributing to tumorigenesis, development, immune escape, and recurrence.
