Article
Immunology
Yan Shen, Fangzheng Yu, Lili Qiu, Mengjia Gao, Puxin Xu, Lingjun Zhang, Xiangyan Liao, Min Wang, Xiangyu Hu, Yan Sun, Yihuai Pan
Summary: The study found that fluoride-resistant Streptococcus mutans has a negative impact on oral microbial ecology and caries prevention.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hong Chen, Sihong Xie, Jing Gao, Liwen He, Wenping Luo, Yunhao Tang, Michael D. Weir, Thomas W. Oates, Hockin H. K. Xu, Deqin Yang
Summary: This study investigated the effects of using flavonoids to inhibit Streptococcus mutans, Candida albicans, and dual-species biofilms, and to protect enamel hardness in a biofilm-based caries model for the first time. Baicalein showed promising results in reducing biofilm formation and protecting enamel hardness in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Kelley N. L. McKinley, Kelly M. Herremans, Andrea N. Riner, Vignesh Vudatha, Devon C. Freudenberger, Steven J. Hughes, Eric W. Triplett, Jose G. Trevino
Summary: This study explores the relationship between the oral and tumor microbiomes in patients with pancreatic ductal adenocarcinoma (PDAC). It reveals a high prevalence and relative abundance of oral bacteria, particularly Veillonella and Streptococcus, in tumor tissue. The most prevalent and abundant taxon, Veillonella atypica, was cultured from patient saliva, sequenced and annotated, identifying genes that may contribute to tumorigenesis. The sequence similarity between patient matched saliva and tumor tissue suggests that the microbiota in PDAC tumors may originate from the mouth. These findings may have clinical implications for the care and treatment of PDAC patients.
Review
Nutrition & Dietetics
Johan Peter Woelber, Ali Al-Ahmad, Kurt Werner Alt
Summary: Plaque control is commonly recommended for preventing caries and periodontal diseases, but modern unnatural lifestyle factors may be the true causes of their high prevalence.
Article
Dentistry, Oral Surgery & Medicine
Olivia Aherne, Roberto Ortiz, Magnus M. Fazli, Julia R. Davies
Summary: Hypochlorous acid (HOCl) stabilized with acetic acid (HAc) has a robust antimicrobial activity on oral biofilms without causing erosion of hydroxyapatite (HA) surfaces or affecting viability of oral keratinocytes, offering potential for prevention and/or treatment of biofilm-mediated oral diseases.
Article
Dentistry, Oral Surgery & Medicine
Heitor Sales de Barros Santos, Naile Dame-Teixeira, Martina Hitomi Nagano, Thuy Do, Clarissa Cavalcanti Fatturi Parolo, Marisa Maltz, Rodrigo Alex Arthur
Summary: This study identified acid tolerance genes in Lactobacillus spp. and found that these genes were over expressed in carious root surfaces. The genes are involved in various functions such as translation, ribosomal structure and biogenesis, and transport of nucleotides and amino acids, which are important for the adaptation of Lactobacillus spp. in acidic environments.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Microbiology
Xiaoying Lyu, Chungen Li, Jin Zhang, Liang Wang, Qingsong Jiang, Yusen Shui, Lan Chen, Youfu Luo, Xin Xu
Summary: The study introduced a novel small molecule, LCG-N25, derived from NAP, which exhibited promising antimicrobial activity against cariogenic bacteria without inducing drug resistance. This new compound could potentially serve as an effective adjuvant in the management of dental caries.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maayan Avraham, Doron Steinberg, Tamar Barak, Miriam Shalish, Mark Feldman, Ronit Vogt Sionov
Summary: The combination treatment of triclosan and cannabidiol (CBD) is more effective in preventing biofilm formation by Streptococcus mutans compared to each compound alone. The combined treatment exhibits stronger anti-bacterial and anti-biofilm activity at lower concentrations without toxicity to normal epithelial cells.
Article
Immunology
Xiuqin Chen, Akanksha Tyagi, Selvakumar Vijayalakshmi, Ramachandran Chelliah, Umair Shabbir, Deog-Hwan Oh
Summary: This study found that the combination of slightly acidic electrolyzed water (SAEW) and sodium benzoate (NaB) can effectively control Streptococcus mutans biofilm, reducing its adhesive strength and decreasing the height of the biofilm. This could be a promising new approach for treating dental caries.
MICROBIAL PATHOGENESIS
(2022)
Article
Multidisciplinary Sciences
Bo-Yan Chen, Wen-Zhen Lin, Yu -Lin Li, Chao Bi, Lin -Juan Du, Yuan Liu, Lu-Jun Zhou, Ting Liu, Shuo Xu, Chao-Ji Shi, Hong Zhu, Yong -Li Wang, Jian-Yong Sun, Yan Liu, Wu -Chang Zhang, Hai-Xia Lu, Yi-Hua Wang, Qiang Feng, Fu -Xiang Chen, Chang-Qian Wang, Maurizio S. Tonetti, Ya-Qin Zhu, Huili Zhang, Sheng-Zhong Duan
Summary: There is evidence linking periodontitis to hypertension, but the nature of this connection is unclear. Dysbiosis of oral microbiota leading to periodontitis can aggravate different systematic diseases, but the alterations of oral and gut microbiota in hypertension and their impacts on blood pressure need further investigation.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Microbiology
Joao Felipe Besegato, Priscila Borges Gobbo de Melo, Adilson Cesar Abreu Bernardi, Marina Trevelin Souza, Edgar Dutra Zanotto, Vanderlei Salvador Bagnato, Alessandra Nara de Souza Rastelli
Summary: This study evaluates the combined use of experimental ultrasound, aPDT, and bioactive glasses for the removal, decontamination, and remineralization of dentin caries lesions. The results suggest that the combination of ultrasound, aPDT, and bioactive glasses can be a promising minimally invasive treatment for caries lesions.
Article
Microbiology
Lanxin Zhang, Samantha Manning, Tong Tong Wu, Yan Zeng, Aaron Lee, Yan Wu, Bruce J. J. Paster, George Chen, Kevin Fiscella, Jin Xiao
Summary: This study evaluated the effects of Nystatin oral rinse on the oral microbiota of adults with oral candidiasis and identified predictive factors for the response to Nystatin. Twenty participants used Nystatin oral rinse for seven days and were followed up after one week and three months. The results showed that the salivary and plaque microbiomes remained stable overall, but a specific genus, Veillonella, emerged in the supragingival plaque after three months in participants who responded well to Nystatin. Additionally, an increased level of salivary Interferon (IFN)-& gamma;-inducible protein (IP-10) was associated with a lack of response to Nystatin rinse.
Review
Microbiology
Seyedeh Sara Aghili, Alireza Jahangirnia, Mostafa Alam, Asal Bagherzadeh Oskouei, Mohsen Golkar, Ashkan Badkoobeh, Kamyar Abbasi, Meysam Mohammadikhah, Shahryar Karami, Reza Sayyad Soufdoost, Reza Abdollahi Namanloo, Sahar Talebi, Samira Amookhteh, Maryam Hemmat, Sima Sadeghi
Summary: This review article aims to summarize the studies on the application of photodynamic therapy (PDT) in preventing and treating oral diseases caused by microbial biofilms in recent decades. Antimicrobial photodynamic therapy (APDT) has shown potential in treating endodontic, periodontal, and mucosal infections caused by bacteria as biofilms. Reactive oxygen species (ROS) induced by a non-toxic photosensitizer (PS) and visible light with appropriate wavelength can cause irreversible damage to microorganisms. However, a standardized protocol for APDT is not yet available.
JOURNAL OF BASIC MICROBIOLOGY
(2023)
Review
Polymer Science
Kan Yu, Qinrou Zhang, Zixiang Dai, Minjia Zhu, Le Xiao, Zeqing Zhao, Yuxing Bai, Ke Zhang
Summary: Smart dental materials are designed to respond intelligently to physiological changes and local environmental stimuli, protecting teeth and promoting oral health. Recent progress has been made in developing materials that possess antibacterial and remineralizing capabilities in response to oral pH, suppressing caries and promoting mineralization. This article reviews cutting-edge research on smart dental materials, discussing their microstructural and chemical designs, physical and biological properties, antibiofilm and remineralizing capabilities, and mechanisms of pH response, as well as exciting new developments and potential clinical applications.
Article
Microbiology
Jonathan J. J. Giacomini, Julian Torres-Morales, Floyd E. E. Dewhirst, Gary G. G. Borisy, Jessica L. Mark L. Welch
Summary: In this study, using genomic analysis and metagenomic information, the taxonomic classification of Veillonella species was clarified and their site specificity was tested. Different Veillonella species showed clear ecological preferences in different oral sites, validating the site specialist hypothesis. Comparative genomic analysis identified genes associated with vitamins and carbohydrates that may determine Veillonella distribution patterns and interspecies interactions.
MICROBIOLOGY SPECTRUM
(2023)