期刊
JOURNAL OF DAIRY SCIENCE
卷 97, 期 10, 页码 6129-6134出版社
ELSEVIER SCIENCE INC
DOI: 10.3168/jds.2014-8344
关键词
Staphylococcus aureus; mastitis; biofilm; lactose; milk
资金
- Talent Project of Anhui Agricultural University (Hefei, Anhui, China) [YJ2013-6]
- National Natural Science Foundation of China (Beijing, China) [31200107]
Staphylococcus aureus is the main etiological organism responsible for bovine mastitis. The ability of S. aureus to form biofilms plays an important role in the pathogenesis of mastitis. Biofilm formation in S. aureus is associated with the production of polysaccharide intercellular adhesin (PIA) protein and several other proteins. Several environmental factors, including glucose, osmolarity, oleic acid, temperature, and anaerobiosis, have been reported to affect biofilm formation in S. aureus. This study investigated the influence of lactose and milk on the biofilm formation capacity of 2 clinical bovine isolates of S. aureus. We found that lactose increased biofilm formation predominantly by inducing PIA production, whereas milk increased biofilm formation through PIA as well as by increasing the production of other biofilm-associated proteins, which might be mediated by the transcriptional regulators intercellular adhesion regulator (icaR) and repressor of biofilm (rbf).
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