Article
Agriculture, Dairy & Animal Science
Joaquin Barca, Ynte H. Schukken, Ana Meikle, Pablo Chilibroste, Mette Bouman, H. Hogeveen
Summary: This randomized controlled trial examined the effects of pegbovigrastim (PEG) treatment on the partial net return of grazing dairy cows. The study found that PEG treatment increased the partial net return and resulted in an economic benefit of $210 ± $100 per cow per year. It also reduced the cost of treatment for clinical mastitis and numerically reduced the cost of culling.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
D. M. Liebe, N. M. Steele, C. S. Petersson-Wolfe, A. De Vries, R. R. White
Summary: This study aimed to build models for predicting clinical mastitis (CM) incidence using time-series sensor data. The study found that model accuracy was crucial in terms of specificity (Sp) and positive predictive value. Additionally, there was an asymmetry between sensitivity (Se) and Sp when the disease incidence rate is low. Consequently, future CM predictive models should consider economic and practical implications.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Infectious Diseases
Anri Timonen, Marju Sammul, Suvi Taponen, Tanel Kaart, Kerli Motus, Piret Kalmus
Summary: This study investigated the usage of antimicrobial drugs in cows with clinical mastitis in large dairy herds in Estonia. The findings revealed that different treatment methods and drugs could impact the outcome of the treatment, and further research is needed to understand the factors that influence veterinarians' choices.
Article
Veterinary Sciences
Honglei Wang, Chen Chen, Chunshuang Liu, Xiaojie Chen, Jingju Zhang, Yufeng Wang, Mingyue Han, Yiming Liu, Xiubo Li
Summary: The clinical dosing regimen of 100 mg/gland every 12 h in a day achieved a 91.08% cure rate for the treatment of bovine mastitis caused by E. coli infection.
BMC VETERINARY RESEARCH
(2023)
Review
Veterinary Sciences
Pamela L. Ruegg
Summary: Treatment of clinical mastitis with antimicrobials is common in adult dairy cows, but few studies have assessed clinical outcomes. Somatic cell count is an important indicator, while differences among approved therapies are minimal.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
T. Tomazi, M. Sumnicht, A. C. C. H. Tomazi, J. C. C. Silva, L. Bringhenti, L. M. Duarte, M. M. M. Silva, M. X. Rodrigues, R. C. Bicalho
Summary: The study evaluated the effect of different intramammary antibiotic interventions on cure rates of clinical mastitis caused by gram-positive bacteria. It found that ceftiofur hydrochloride treatment had better clinical cure rates compared to amoxicillin treatment. Quarters in the negative control group had higher cfu counts compared to antibiotic-treated groups post-enrollment.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Infectious Diseases
Stefan Borchardt, Wolfgang Heuwieser
Summary: The study compared immediate intramammary antimicrobial treatment of mild and moderate clinical mastitis with a selective treatment protocol based on on-farm culture results. The results showed that implementing a pathogen-based treatment protocol for these cases can effectively reduce antimicrobial use without negative effects on cow health.
Article
Infectious Diseases
Franziska Preine, Demetrio Herrera, Christian Scherpenzeel, Piret Kalmus, Finola McCoy, Sebastian Smulski, Paivi Rajala-Schultz, Anne Schmenger, Paolo Moroni, Volker Kromker
Summary: This study compares the therapeutic approaches for mastitis treatment in lactation in different European countries. Veterinarians make the treatment decisions and farm personnel are responsible for treatment administration. Penicillin is increasingly becoming the first-choice drug for mastitis treatment. The use of critically important antimicrobials is limited in some countries. Monitoring systems for antibiotic use are being introduced in more countries. The exchange of different views can help European countries move towards a common high standard of antimicrobial stewardship in veterinary medicine.
Article
Agriculture, Dairy & Animal Science
Melina Richardet, Hernan G. Solari, Victor E. Cabrera, Claudina Vissio, Daniel Aguero, Julian A. Bartolome, Gabriel A. Bo, Cristina I. Bogni, Alejandro J. Larriestra
Summary: A simulation model was developed to capture the complexity and dynamics of bovine mastitis, considering its multiple effects. The model allows for customization and supports decision-making of producers and veterinarians.
Review
Agriculture, Dairy & Animal Science
Ellen de Jong, Kayley D. McCubbin, David Speksnijder, Simon Dufour, John R. Middleton, Pamela L. Ruegg, Theo J. G. M. Lam, David F. Kelton, Scott McDougall, Sandra M. Godden, Alfonso Lago, Paeivi J. Rajala-Schultz, Karin Orsel, Sarne De Vliegher, Volker Kromker, Diego B. Nobrega, John P. Kastelic, Herman W. Barkema
Summary: The treatment of clinical mastitis (CM) and the use of antimicrobials for dry cow therapy account for a large amount of antimicrobial use (AMU) on dairy farms. However, recent advancements have allowed for the exclusion of nonsevere CM cases that are likely to be cured without antimicrobials, as well as cases with a low bacteriological cure rate. These advancements include the availability of rapid diagnostic tests and improved udder health management practices. This review provides an evidence-based protocol for selective CM treatment decisions, which can aid in reducing AMU, improving udder health, and benefiting farm economics.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Infectious Diseases
Jensine Wilm, Line Svennesen, Esben Ostergaard Eriksen, Tariq Halasa, Volker Kromker
Summary: The study investigated the treatment approach of Danish veterinarians towards clinical mastitis, finding that it generally involves systemic and intramammary antibiotic administration along with supportive nonsteroidal anti-inflammatory drugs. Challenges were identified in targeting treatment towards pathogens due to delays in current analysis practices, leading veterinarians to start treatment immediately rather than waiting for test results. Recommendations for improvement include encouraging rapid pathogen determination methods to target treatments effectively and potentially reducing combined antibiotic administration in specific cases.
Article
Microbiology
Isabel Krebs, Yanchao Zhang, Nicole Wente, Stefanie Leimbach, Volker Kromker
Summary: This study investigated factors associated with the severity of clinical mastitis (CM). The most common pathogens isolated were Escherichia coli and Streptococcus spp. High pathogen shedding, low previous somatic cell count (SCC), high outside temperature, and high humidity were associated with severe mastitis.
Article
Microbiology
Frederik Fredebeul-Krein, Anne Schmenger, Nicole Wente, Yanchao Zhang, Volker Kroemker
Summary: Severe mastitis can cause significant damage to the general condition of cows, even leading to sepsis and death. This study identified coliform bacteria and increasing pathogen shedding as factors associated with the severity of mastitis. Additionally, lactation stages and previous diseases prior to mastitis were found to be related to the progression of severe mastitis in cows. Understanding these risk factors can serve as a basis for further research on the exact influence they have on mastitis severity.
Article
Veterinary Sciences
Thomas Le Page, Sebastien Buczinski, Jocelyn Dubuc, Josiane Labonte, Jean-Philippe Roy
Summary: This study developed a tool for predicting the risk of death or culling in cases of severe clinical mastitis, helping veterinarians in prognosis prediction. The tool is important for making euthanasia decisions in poor prognosis cases.
VETERINARY SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ruifu Chen, Junpeng Chen, Ajing Peng, Lihua Yang, Ruijuan Zhou
Summary: This study compared the efficacy of VSD and precise ultrasound-guided debridement in the treatment of non-lactational mastitis, finding both methods to be satisfactory without significant differences. VSD is suitable for patients with inverted nipples and skin ulcers, while precise ultrasound-guided debridement is more suitable for patients with abscesses, small incisions, and short hospital stays.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Veterinary Sciences
Maya Gussmann, Carsten Kirkeby, Daniel Schwarz, Michael Farre, Tariq Halasa
PREVENTIVE VETERINARY MEDICINE
(2020)
Article
Veterinary Sciences
Tariq Halasa, Kaare Graesboll, Matthew Denwood, Lasse Engbo Christensen, Carsten Kirkeby
FRONTIERS IN VETERINARY SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Carsten Kirkeby, Daniel Schwarz, Matt Denwood, Michael Farre, Soren S. Nielsen, Maya Gussmann, Nils Toft, Tariq Halasa
Summary: The study found that the dynamics of SCC and DSCC after IMI varied between dairy herds, with differing effects depending on the causative pathogens.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemical Research Methods
Nina Matsumoto, Jarunee Siengsanan-Lamont, Laurence J. Gleeson, Bounlom Douangngeun, Watthana Theppangna, Syseng Khounsy, Phouvong Phommachanh, Tariq Halasa, Russell D. Bush, Stuart D. Blacksell
JOURNAL OF VIROLOGICAL METHODS
(2020)
Article
Agriculture, Dairy & Animal Science
Anette Boklund, Anne Sofie Hammer, Michelle Lauge Quaade, Thomas Bruun Rasmussen, Louise Lohse, Bertel Strandbygaard, Charlotte Svaerke Jorgensen, Ann Sofie Olesen, Freja Broe Hjerpe, Heidi Huus Petersen, Tim Kare Jensen, Sten Mortensen, Francisco F. Calvo-Artavia, Stine Kjaer Lefevre, Soren Saxmose Nielsen, Tariq Halasa, Graham J. Belsham, Anette Botner
Summary: Since 2019, SARS-CoV-2 has become a global pandemic, spreading to mink farms in the Netherlands and Denmark, where infected mink can easily transmit the virus within farms and to humans through close contact. The virus was detected in various samples from infected farms, showcasing the susceptibility of mink to SARS-CoV-2, but the exact routes of transmission between farms remain unclear, with direct human contact still being the primary mode of transmission.
Article
Veterinary Sciences
Tariq Halasa, Carsten Kirkeby
FRONTIERS IN VETERINARY SCIENCE
(2020)
Article
Veterinary Sciences
Carsten Kirkeby, Victoria J. Brookes, Michael P. Ward, Salome Durr, Tariq Halasa
Summary: Computer-based disease spread models are commonly used in veterinary science to predict disease impacts, plan control strategies, and provide insights into disease causation. Individual-based models are a specific type of disease spread models, and can be built using practical methods and code examples. Important steps in building these models include verification, validation, and convergence analysis, as well as sensitivity analysis to assess the impact of parameter uncertainty. Recent developments in disease spread models are also discussed.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Jensine Wilm, Line Svennesen, Esben Ostergaard Eriksen, Tariq Halasa, Volker Kromker
Summary: The study investigated the treatment approach of Danish veterinarians towards clinical mastitis, finding that it generally involves systemic and intramammary antibiotic administration along with supportive nonsteroidal anti-inflammatory drugs. Challenges were identified in targeting treatment towards pathogens due to delays in current analysis practices, leading veterinarians to start treatment immediately rather than waiting for test results. Recommendations for improvement include encouraging rapid pathogen determination methods to target treatments effectively and potentially reducing combined antibiotic administration in specific cases.
Article
Infectious Diseases
Nina Matsumoto, Jarunee Siengsanan-Lamont, Tariq Halasa, James R. Young, Michael P. Ward, Bounlom Douangngeun, Watthana Theppangna, Syseng Khounsy, Jenny-Ann L. M. L. Toribio, Russell D. Bush, Stuart D. Blacksell
Summary: The study investigated the outbreak of African swine fever virus (ASFV) in smallholder villages in Thapangtong, Laos, finding significant financial losses and the need for increased local government resources, monitoring of wild boars, and educational support to address risk factors within the villages.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Veterinary Sciences
Carsten Kirkeby, Tariq Halasa, Michael Farre, Galal Nazih Chehabi, Kaare Graesboll
Summary: This study investigated the transmission dynamics of Corynebacterium spp. in two Danish dairy cattle herds. It was found that these bacteria can be prevalent within the herd and transmit directly between cows. The study highlighted the importance of researching cost-effective control measures against Corynebacterium spp.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Francis Edwardes, Mariska van der Voort, Tariq Halasa, Menno Holzhauer, Henk Hogeveen
Summary: Hoof disorders and sub-optimal mobility have significant economic impacts on dairy farming. Previous simulation models did not consider the dynamics of hoof disorders and their varying severities. This study developed a novel bio-economic simulation model to estimate the economic loss of sub-optimal mobility caused by different hoof disorders.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Veterinary Sciences
Catharina E. Exel, Tariq Halasa, Gerrit Koop, Wilma Steeneveld, Theo J. G. M. Lam, Lindert Benedictus, Maya Gussmann
Summary: The study found that different S. aureus strains have a significant impact on the economic and epidemiologic outcomes of various intervention strategies. Among 19 different intervention strategies, culling cows with a recovery probability lower than 50% was the most effective strategy for most strains.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Veterinary Sciences
Jake Fountain, Marta Hernandez-Jover, Carsten Kirkeby, Tariq Halasa, Jennifer Manyweathers, Yiheyis Maru, Victoria Brookes
Summary: This study developed a simulation model to explore the impact of BVDV on beef cattle production in southeast Australia, finding that disease transmission in cattle herds is influenced by introduction time and herd size, with short- and long-term economic impacts on production outputs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biology
Anna Irene Vedel Sorensen, Julie Elvekjaer Hansen, Tariq Halasa
JOURNAL OF THEORETICAL BIOLOGY
(2020)
Article
Immunology
Anne Sofie Hammer, Michelle Lauge Quaade, Thomas Bruun Rasmussen, Jannik Fonager, Morten Rasmussen, Karin Mundbjerg, Louise Lohse, Bertel Strandbygaard, Charlotte Svaerke Jorgensen, Alonzo Alfaro-Nunez, Maiken Worsoe Rosenstierne, Anette Boklund, Tariq Halasa, Anders Fomsgaard, Graham J. Belsham, Anette Botner
Summary: Novel virus variants in farmed mink in Denmark were found to subsequently appear in the local human community, highlighting the potential for interspecies transmission of the virus.
EMERGING INFECTIOUS DISEASES
(2021)