Article
Agriculture, Dairy & Animal Science
Bethany Dado-Senn, Amy L. Skibiel, Geoffrey E. Dahl, Sebastian I. Arriola Apelo, Jimena Laporta
Summary: Heat stress during the dry period reduces milk yield, protein content, and protein yield in subsequent lactation, impacting mammary metabolism.
Review
Nanoscience & Nanotechnology
John D. Martin, Takuya Miyazaki, Horacio Cabral
Summary: The article discusses the progress in re-engineering the tumor microenvironment using nanomedicine, focusing on controlling drug action and modulating TME characteristics to improve the efficacy of anti-tumor treatments. It emphasizes the importance of re-engineering the TME to a quiescent state rather than destroying it, and discusses the immediate challenges and future prospects for TME-re-engineering nanomedicines.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Veronique Ouellet, Joao Negrao, Amy L. Skibiel, Valerie A. Lantigua, Thiago F. Fabris, Marcela G. Marrero, Bethany Dado-Senn, Jimena Laporta, Geoffrey E. Dahl
Summary: Late-gestation heat stress alters gene expression in the mammary gland, impacting key cellular processes and potentially disrupting mammary gland remodelling by modulating estrogen and prolactin signalling, leading to reduced milk yield in the subsequent lactation. Further research is needed to uncover the mechanisms behind production impairments caused by late-gestation heat stress.
Article
Biochemistry & Molecular Biology
Kazadi N. Mutoji, Mingxia Sun, Garrett Elliott, Isabel Y. Moreno, Clare Hughes, Tarsis F. Gesteira, Vivien J. Coulson-Thomas
Summary: After a corneal chemical injury, there were significant changes in the distribution of PGs, with an overall increase in CS and an increase in KS expression at a certain period, indicating the crucial roles of PGs and GAGs in maintaining corneal transparency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zaneta Dziegelewska-Sokolowska, Alicja Majewska, Adam Prostek, Malgorzata Gajewska
Summary: The mammary gland consists of epithelial tissue and stroma, with preadipocytes and adipocytes as important components of the stroma. This study investigated the effects of paracrine factors secreted by preadipocytes and adipocytes on the development of bovine mammary epithelial cells. The results showed that factors secreted by fully differentiated adipocytes and preadipocytes can decrease apoptosis and increase the size of spheroids formed by the mammary epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Anna Stejskalova, Victoria Fincke, Melissa Nowak, Yvonne Schmidt, Katrin Borrmann, Marie-Kristin von Wahlde, Sebastian D. Schaefer, Ludwig Kiesel, Burkhard Greve, Martin Goette
Summary: This study utilized endometrial spheroids to mimic the architecture of the endometrium and found that stromal spheroids exhibited coordinated directional migration on collagen I, resembling ectopic lesions. The spheroid assay proves to be a useful pre-clinical tool for evaluating potential treatments for endometriosis, including small molecule drugs and microRNA-based therapeutics.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
B. Krattley-Roodenburg, L. J. Huybens, M. Nielen, T. van Werven
Summary: The study aimed to investigate the effects of different management practices on udder health during the dry period, and found that factors such as reducing milk yield before dry-off, correct use of antimicrobials, and adherence to guidelines can help reduce the risk of new high SCC. The research also showed that farmers can balance limited use of antimicrobials at dry-off with management measures to maintain good udder health during the dry period.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Amy L. Skibiel, Jin Koh, Ning Zhu, Fanchao Zhu, Mi-Jeong Yoo, Jimena Laporta
Summary: Exposure to heat stress during dry period impairs mammary gland remodeling and function, leading to decreased milk production during lactation. This study investigated the proteomic and phosphoproteomic changes in the lactating mammary gland as a result of dry period heat stress, revealing the molecular mechanisms underlying disrupted mammary function and health.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Maddison Archer, Pallave Dasari, David Walsh, Kara L. Britt, Andreas Evdokiou, Wendy Ingman
Summary: Mammographic density is associated with increased breast cancer risk. This study found that fibroblasts from high mammographic density breast tissue do not show inherent differences compared to those from low mammographic density, suggesting that the function of fibroblasts in breast cancer risk may be regulated by immune signals from surrounding cells in the microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Tracy J. Berg, Alexander Pietras
Summary: Cancer cells often exploit stromal cells' functions to support tumor progression and resistance to treatment. Therapies targeting cancer cells also affect stromal cells, leading to various responses that may promote tumor progression and treatment resistance. This review focuses on the response of stromal cells to cancer therapy, particularly radiotherapy in glioblastoma. Understanding how stromal cells respond to therapy can provide insights into potential targets to enhance tumor response to existing treatments.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong Xuan, Xiaodong Zhao, Qing Li, Yilin Zhao, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Zhibin Ji, Tianle Chao, Jianmin Wang
Summary: This study investigated the expression characteristics and molecular functions of long noncoding RNA (lncRNA) in goat mammary gland tissue. The results showed that lncRNA expression is differentially regulated at different stages of mammary gland involution and remodeling, and lncRNAs play a role in regulating various physiological activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Dairy & Animal Science
Rong Xuan, Tianle Chao, Xiaodong Zhao, Aili Wang, Yunpeng Chu, Qing Li, Yilin Zhao, Zhibin Ji, Jianmin Wang
Summary: This study investigated the structural and transcriptome changes of mammary gland tissue in nonlactating dairy goats during late lactation, the dry period, and late gestation. The results showed significant structural changes and cell apoptosis in the mammary gland tissue. Transcriptome analysis identified 1,381 genes with differential expression at the three developmental stages. Genes related to cell growth, apoptosis, immunity, nutrient transport, synthesis, and metabolism exhibited adaptive transcriptional changes.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biology
Kohei Saeki, Gregory Chang, Noriko Kanaya, Xiwei Wu, Jinhui Wang, Lauren Bernal, Desiree Ha, Susan L. Neuhausen, Shiuan Chen
Summary: The study presents an integrated mammary cell gene expression atlas derived from mouse and human single-cell RNA-sequence data, characterizing key life stages of mammary gland remodeling and inferring cells of origin for various breast cancer subtypes using breast cancer expression data.
COMMUNICATIONS BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
A. Kok, R. J. van Hoeij, B. Kemp, A. T. M. van Knegsel
Summary: Customized dry-period strategies using decision trees can help mitigate negative impacts of shortening or omitting the dry period on milk production and udder health, while retaining benefits from improved energy balance and fertility.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rong Xuan, Jianmin Wang, Qing Li, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Peipei He, Zhibin Ji, Tianle Chao
Summary: This study conducted transcriptome sequencing of goat-mammary-gland tissue at different developmental stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified, with 2528 circRNAs expressed in all three stages. Gene ontology analysis showed functional diversity of circRNAs' source genes. Furthermore, differentially expressed circRNAs and circRNA-miRNA-mRNA ceRNA regulatory networks were identified, providing insights into the regulatory role of circRNAs in mammary cell involution and remodeling.
Article
Agriculture, Dairy & Animal Science
C. J. McCabe, A. Suarez-Trujillo, K. A. Teeple, T. M. Casey, J. P. Boerman
Summary: Exposure to chronic light-dark phase shifts in late gestation decreased mammary development and increased insulin resistance in periparturient cows, resulting in subsequent lower milk yield.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Barry Donovan, Aridany Suarez-Trujillo, Theresa Casey, Uma K. Aryal, Dawn Conklin, Leonard L. Williams, Radiah C. Minor
Summary: Supplementing sow's feed with oat or yeast can increase milk proteins related to immune protection and reduce post-weaning diarrhea in piglets. While piglets born from oat-supplemented sows had higher birth weights, those born from sows supplemented with yeast and oat together had lower weights at weaning, indicating a potential negative impact on weight gain. Maternal diet supplementation with pre- and probiotics can positively affect milk, growth, and health of offspring.
Article
Agriculture, Dairy & Animal Science
T. M. Casey, K. Plaut, J. Boerman
Summary: Circadian rhythms are crucial for regulating physiological changes during pregnancy and lactation. Disruption of the circadian timing system can impact mammary gland development, maternal metabolism, and milk production.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
R. N. Klopp, C. R. Ferreira, T. M. Casey, J. P. Boerman
Summary: This study aimed to investigate the relationships between circulating and colostrum lipids in cows and calves, and the effects of maternal metabolic status on circulating and colostrum lipids. The results showed that circulating lipids in cows and calves were distinct from colostrum lipids, except for phosphatidylglycerol (PG), where colostrum appeared to serve as the source for PG in the calf's circulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Aridany Suarez-Trujillo, Nguyen Hoang, Leela Robinson, Conor J. McCabe, Dawn Conklin, Radiah C. Minor, Jonathan Townsend, Karen Plaut, Uduak Z. George, Jacquelyn Boerman, Theresa M. Casey
Summary: The metabolic, circadian, sleep, and reproductive systems are interconnected and regulated, but the understanding of their mechanism is limited. This study disrupted the circadian timing system in pregnant nonlactating cows and found that body temperature and hormone concentrations were affected, especially in relation to gestation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Bryce Bitsie, Erin Kay Ison, Leah Parker Jenkins, Rebecca Klopp, Conor McCabe, Kayla Mills, Griffin Nicholls, Andrew Richards, Larissa Shirley, Kelsey Teeple, Allan P. Schinckel, Angela Kwon, Kara R. Stewart, Amber Jannasch, Aridany Suarez-Trujillo, Theresa M. Casey
Summary: The early nutritional environment of female animals has an impact on their lactating ability as adults, with the level of colostrum intake affecting mammary development and DNA synthetic rate. Higher levels of lysine in the perinatal period favored cell division over differentiation in the mammary glands of neonatal pigs. Further research is required to explore these relationships.
Review
Agriculture, Dairy & Animal Science
Theresa M. Casey, Karen Plaut
Summary: Understanding the biology of circadian clocks is crucial for optimizing cow health and production efficiency. Circadian clocks regulate metabolic and reproductive systems, and disruption of these clocks can negatively affect mammary development and lactation in dairy cows. External and internal cues, such as light and nutrients, play a role in setting the timing of circadian rhythms.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Adedeji Adetunji, Theresa Casey, Jackeline Franco, Devendra Shah, Yewande Fasina
Summary: Proteomic analysis revealed significant changes in the spleen proteome of broiler chickens infected with Salmonella enteritidis, including alterations in cell cycle progression, cytoskeleton, mRNA processing, redox homeostasis, lysosomal activities, energy production, and developmental progression.
Article
Agriculture, Dairy & Animal Science
Prabha Rajput, Uma K. Aryal, Ketaki Bhide, Radiah C. Minor, Sairam Krishnamurthy, Theresa M. Casey
Summary: Lectin-based affinity purification and shotgun proteome analysis were used to identify 545 glycosylation sites on 220 glycoproteins in sow milk. Glycoproteins were found in all three phases of milk production and showed variations in abundance and glycosylated site distribution between colostrum, transitional, and mature milk.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biology
Kayla Mills, Jocelyn Sheets, Kelsey Teeple, Adrianna Mann, Aridany Suarez-Trujillo, Kara Stewart, Christina Ferreira, Theresa Casey
Summary: Low colostrum intake is associated with poor health and fertility in swine. This study found that the lipid profiles in the vaginal area are correlated with colostrum intake and weight gain in piglets. Animals with low colostrum intake had abnormal lipid compositions, suggesting potential dysfunction.
Article
Multidisciplinary Sciences
Kelsey Teeple, Prabha Rajput, Maria Gonzalez, Yu Han-Hallett, Esteban Fernandez-Juricic, Theresa Casey
Summary: Excessive fatness and circadian disruption affect physiology and hormones, such as cortisol, in female mice. Feeding a high fat diet to mice resulted in increased daytime feeding, weight gain, body fat percentage, hair corticosterone levels, and disrupted fecal corticosterone rhythms.
Article
Agriculture, Dairy & Animal Science
Linda M. Beckett, Victor M. R. Malacco, Susan Hilger, Theresa M. Casey, Shawn S. Donkin
Summary: This study examines the effects of post-ruminal infusion of palm oil or flaxseed oil with propionate or acetate on blood metabolites and hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase expression. The infusion of flaxseed oil changes plasma cis C18:3n-3 but has no effect on PC or PCK1 expression. Infusion of palm oil has no effect on plasma metabolites or PC or PCK1 expression.
Meeting Abstract
Agriculture, Dairy & Animal Science
Kara R. Stewart, Theresa Casey, Christina Ferreria
JOURNAL OF ANIMAL SCIENCE
(2022)
Meeting Abstract
Agriculture, Dairy & Animal Science
Jocelyn V. Sheets, Kayla Mills, Kara R. Stewart, Theresa Casey
JOURNAL OF ANIMAL SCIENCE
(2022)
Meeting Abstract
Agriculture, Dairy & Animal Science
Mercedes E. Brunton, Maria Elisa Montes, Adrianna Mann, Kelsey Teeple, Uduak George, Jaquelyn P. Boerman, Theresa Casey
JOURNAL OF ANIMAL SCIENCE
(2022)