Article
Microbiology
Conrad Izydorczyk, Barbara J. Waddell, Christina S. Thornton, John M. Conly, Harvey R. Rabin, Ranjani Somayaji, Michael G. Surette, Deirdre L. Church, Michael D. Parkins
Summary: This study investigated the natural history, transmission potential, and evolution of Stenotrophomonas maltophilia in a large Canadian cohort of 321 cystic fibrosis patients over a 37-year period. The findings revealed that S. maltophilia was recovered in 25.5% of the patients and shared pulsotypes were observed between different patients. Genomic analyses suggested common, indirect sources as the origins of S. maltophilia infections in the clinic population. These findings contribute to the understanding of S. maltophilia infection dynamics in cystic fibrosis patients.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Microbiology
Joanna S. Brooke
Summary: Stenotrophomonas maltophilia is an opportunistic pathogen that can cause various infections and has intrinsic drug resistance. Research is ongoing to uncover new strategies to combat this pathogen, which possesses diverse virulence factors and adaptability to different environments.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Medicine, General & Internal
Katarzyna Walicka-Serzysko, Magdalena Postek, Justyna Milczewska, Dorota Sands
Summary: Pulmonary exacerbation (PEx) significantly impacts the quality of life and life expectancy of patients with cystic fibrosis (CF). In our study, we found that LCI increased by 65% and FEV1 decreased by ≥10% in 40% of CF patients during PEx. After PEx treatment, FEV1 increased by 11.05% on average, while LCI decreased by 1.21 units on average, representing a 9.42% decrease compared to the beginning of PEx.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Genetics & Heredity
Quentin Menetrey, Pauline Sorlin, Estelle Jumas-Bilak, Raphael Chiron, Chloe Dupont, Helene Marchandin
Summary: In patients with cystic fibrosis, the lung microbiome experiences important selective pressures, leading to colonization by both common and emerging pathogens. Competitive interactions and evolutionary modifications among bacteria are major drivers of persistence in the CF lung, with emerging pathogens like Achromobacter xylosoxidans and Stenotrophomonas maltophilia becoming important members of the complex bacterial community in the CF lung.
Article
Respiratory System
Suzanne C. Carter, Alessandro N. Franciosi, Kate M. O'Shea, Orla M. O'Carroll, Ashutosh Sharma, Aoife Bell, Brian Keogan, Paul O'Reilly, Suzie Coughlan, Sheonagh M. Law, Robert D. Gray, Katherine B. Hisert, Pradeep K. Singh, Gordon Cooke, Brenda Grogan, Cillian F. De Gascun, Charles G. Gallagher, Trevor T. Nicholson, Bradley S. Quon, Edward F. McKone
Summary: This study reveals that there are different subphenotypes of CF pulmonary exacerbations, characterized by differences in biomarker profiles, clinical presentation, and outcomes. Viral infection status and C-reactive protein levels can be used to classify these subphenotypes, providing potential guidance for predicting prognosis.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Microbiology
Eliana Alcaraz, Daniela Centron, Gabriela Camicia, Maria Paula Quiroga, Jose Di Conza, Beatriz Passerini de Rossi
Summary: The study investigated sequential isolates of S. maltophilia from a Brazilian adult patient with CF, revealing a gradual loss of virulence factors possibly associated with high DSF production in evolved isolates. Additionally, late isolates showed decreased mutation rate and belonged to two related clones.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Respiratory System
Maryam Hassanzad, Arda Kiani, Atefeh Abedini, Hoseinali Ghaffaripour, Habib Emami, Niloufar Alizadeh, Ghazal Zoghi, Saeed Hashemi, Ali Akbar Velayati
Summary: Lung ultrasound (LUS) shows better diagnostic performance in evaluating cystic fibrosis (CF) pulmonary exacerbation, especially in detecting air bronchogram and consolidation. LUS exhibits high specificity for diagnosing pleural effusion and atelectasis.
BMC PULMONARY MEDICINE
(2021)
Article
Respiratory System
Christian Ronn, Peter Kamstrup, Josefin Eklof, Louise Lindhardt Toennesen, Jonas Bredtoft Boel, Christian Ostergaard Andersen, Ram Benny Dessau, Jon Torgny Wilcke, Pradeesh Sivapalan, Charlotte Suppli Ulrik, Jens-Ulrik Staehr Jensen
Summary: This observational cohort study found that a lower respiratory tract culture positive for S. maltophilia in COPD patients was associated with significantly increased mortality and hospitalisation for exacerbation of COPD. Randomised controlled trials are suggested to explore the potential of antibiotic treatment targeting S. maltophilia.
RESPIRATORY RESEARCH
(2023)
Article
Microbiology
Yue Li, Ailan Zhao, Qin Yu, Nan Yu, Yao Cui, Xiaohan Ma, Haican Liu, Ruibai Wang
Summary: Tuberculosis (TB) is a significant infectious disease in China and accurate diagnosis and treatment are vital for TB prevention and control. A study found that Stenotrophomonas maltophilia, a multidrug-resistant bacterium, was isolated from stored Mtb cultures and had a negative impact on TB diagnosis and treatment. S. maltophilia showed resistance to multiple anti-TB drugs and altered the drug sensitivity test results, requiring attention and further research.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Giovanni Di Bonaventura, Carla Picciani, Veronica Lupetti, Arianna Pompilio
Summary: In this study, a proteomic approach was used to investigate the differential protein expression patterns during the planktonic-to-biofilm transition of Stenotrophomonas maltophilia. 57 proteins were found to be differentially expressed in biofilm cells compared to planktonic cells, with 38 overexpressed and 19 down-expressed. These findings provide insights into determinants potentially associated with S. maltophilia biofilm formation and may be used for developing effective anti-biofilm strategies against this bacterium.
Article
Microbiology
Jack P. Law, A. Jamie Wood, Ville-Petri Friman
Summary: This study investigated the impact of sub-minimum inhibitory concentration (MIC) antibiotic exposure on the tolerance evolution of Pseudomonas aeruginosa in polymicrobial cystic fibrosis (CF) infections. The presence of antibiotics drove the evolution of antibiotic tolerance, with reciprocal cross-tolerance observed between ciprofloxacin and tobramycin. The presence of Stenotrophomonas maltophilia did not affect tolerance or MIC evolution, but increased the likelihood of P. aeruginosa extinction in the presence of tobramycin.
MICROBIOLOGY SPECTRUM
(2022)
Editorial Material
Microbiology
Daniel D. Rhoads
Summary: Stenotrophomonas maltophilia is inherently resistant to several antibiotics, making treatment challenging. Automated susceptibility testing for S. maltophilia is limited by the performance of commercial test systems, requiring practical implementation and risk mitigation strategies.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rima Fanaei Pirlar, Jeroen Wagemans, Fabian Kunisch, Rob Lavigne, Andrej Trampuz, Mercedes Gonzalez Moreno
Summary: CUB19 is a novel bacteriophage that specifically targets the bacterial species Stenotrophomonas maltophilia. It exhibits stability over a wide range of temperatures and pH values and has potent antimicrobial and antibiofilm activity. The study also suggests that CUB19 is effective when co-administered with antibiotics, making it a promising targeted therapeutic agent against biofilm-associated Stenotrophomonas infections.
Article
Microbiology
Rebecca Horch, Diana Rasp, Annika Dietz, Ronald Ebbert, Joerg Steinmann, Ulrich E. Schaible, Uwe Mamat, Ralph Bertram
Summary: Stenotrophomonas maltophilia is an important nosocomial pathogen with intrinsic resistance to antibiotics. The implementation of tet regulation allows for the regulation of gene expression and provides a deeper understanding of its physiology and virulence.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Danuta Wojcieszynska, Judyta Klamka, Ariel Marchlewicz, Izabela Potocka, Joanna Zur-Pinska, Urszula Guzik
Summary: In this study, a plant sponge from Luffa cylindrica was used as a carrier for the immobilization of Stenotrophomonas maltophilia KB2 strain. The optimal conditions for immobilization were determined, and the immobilized strain showed potential for bioremediation processes.
Article
Respiratory System
Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B. Sanders, Stephanie D. Davis, Felix Ratjen
Summary: The changes in lung clearance index (LCI) have different thresholds for clinical relevance in children with cystic fibrosis (CF), and these thresholds can also be applied to healthy children.
Article
Respiratory System
Isabel Gascon Casaredi, Michelle Shaw, Valerie Waters, Ryan Seeto, Ana C. Blanchard, Felix Ratjen
Summary: This study conducted long-term follow-up observation on cystic fibrosis patients and found that antibiotic eradication therapy (AET) can improve lung function in patients with early Pseudomonas aeruginosa infection.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Review
Oncology
Grace Kusi, Eshetu G. Atenafu, Adwoa Bemah Boamah Mensah, Charlotte T. Lee, Auro Viswabandya, Martine Puts, Samantha Mayo
Summary: Psychoeducational intervention (PEI) has a positive effect on cancer caregivers, reducing caregiver burden, improving quality of life, and reducing anxiety and depression. The study also found that intervention characteristics such as studies conducted in high-income countries, group interventions, and studies focused on specific and mixed cancers can impact the effectiveness of the intervention.
Letter
Hematology
Marta Davidson, Florence Wong, Mostafa Atri, Hassan Sibai, Dawn Maze, Verna Cheung, Jeannie Callum, Eshetu G. Atenafu, Vikas Gupta
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biophysics
Maria Queralt Salas, Eshetu G. G. Atenafu, Ivan Pasic, Eshrak Al-Shaibani, Ora Bascom, Leeann Wilson, Carol Chen, Arjun Datt Law, Wilson Lam, Igor Novitzky-Basso, Dennis (Dong Hwan) Kim, Armin Gerbitz, Auro Viswabandya, Fotios V. V. Michelis, Jeffrey Howard Lipton, Jonas Mattsson, Shabbir Alibhai, Rajat Kumar
Summary: This study designs an HCT Frailty Scale to classify alloHCT candidates into different frailty groups, which can be implemented in the first consultation without additional cost. The scale uses eight variables to assess and calculate the frailty score of a patient, which can predict the one-year overall survival rate. The scale is a low-cost and highly informative prognostic signal for outcomes at the pre-transplant stage.
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Samantha A. Hershenfeld, Eshetu G. Atenafu, Steven Chan, Vikas Gupta, Dawn Maze, Andre Schuh, Hassan Sibai, Karen Yee, Aaron Schimmer
Summary: This study found that distance from the treatment center did not significantly affect the choice of upfront therapy, participation in clinical trials, or clinical outcomes for patients with acute myeloid leukemia (AML) in Ontario's single payer healthcare system.
ACTA HAEMATOLOGICA
(2023)
Article
Hematology
James T. T. England, Eshetu G. G. Atenafu, James A. A. Kennedy, Burhan Goraya, Verna Cheung, Taylor Nye, Karine Gauthier, Marta B. B. Davidson, Aniket Bankar, Hassan Sibai, Dawn Maze, Auro Viswabandya, Vikas Gupta
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
RuiQi Chen, Eshetu G. Atenafu, Jack Seki, Xing Liu, Steven Chan, Vikas Gupta, Dawn Maze, Andre C. Shuh, Mark D. Minden, Karen Yee, Aaron D. Schimmer, Hassan Sibai
Summary: This study found that PEG-ASP is associated with a higher incidence of VTE compared to L-ASP in patients with ALL, despite prophylactic anticoagulation. Further VTE mitigation strategies are needed for adult patients receiving PEG-ASP.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Jawad M. Melhem, Ali Tahir, Eirena Calabrese, Inga Granovskaya, Eshetu G. Atenafu, Arjun Sahgal, Mary Jane Lim-Fat, James R. Perry
Summary: This study aimed to validate the safety and efficacy of low-dose bevacizumab (BEV) for patients with recurrent glioblastoma (rGBM). The study found that compared to the standard dose regimen, low-dose BEV was associated with significantly prolonged overall survival and progression-free survival. Lower dose schedules may be a better and more cost-effective option, providing more equitable access to the palliative drug.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Editorial Material
Pediatrics
Ediane De Queiroz Andrade, Brooke Bailey, Jane C. C. Davies, Renee Jensen, Felix Ratjen, Clare J. J. Saunders, Christopher Short, Paul D. D. Robinson
PEDIATRIC PULMONOLOGY
(2023)
Review
Respiratory System
Lucy Perrem, Isaac Martin, Felix Ratjen
Summary: Pulmonary exacerbations in children with cystic fibrosis are common and even mild clinical events contribute to the progression of lung disease. Prompt diagnosis and management are necessary to preserve lung function.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Editorial Material
Respiratory System
Christine Bear, Felix Ratjen
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Nazanin Aghel, Dakota Gustafson, Diego Delgado, Eshetu G. Atenafu, Jason E. Fish, Jeffrey H. Lipton
Summary: Tyrosine kinase inhibitors (TKIs) have had a significant impact on the treatment of chronic myelogenous leukemia (CML), but they may have cardiovascular toxicities. This study examined the relationship between the marker hsCRP and vascular dysfunction markers with exposure to specific TKIs in CML patients. The results showed that hsCRP levels were not associated with disease activity or treatment with specific TKIs, but other markers of vascular dysfunction were altered in patients treated with certain TKIs.
LEUKEMIA & LYMPHOMA
(2023)
Article
Pediatrics
Dvir Gatt, Michelle Shaw, Valerie Waters, Fiona Kritzinger, Melinda Solomon, Sharon Dell, Felix Ratjen
Summary: This retrospective study analyzed 52 pulmonary exacerbation events in 28 children with PCD between 2010 and 2022. The majority of lung function recovery occurred within the first week of IV therapy. Lower BMI was associated with nonresponse to treatment.
PEDIATRIC PULMONOLOGY
(2023)
Letter
Respiratory System
Elias Seidl, Johann-Christoph Licht, Wallace B. Wee, Martin Post, Felix Ratjen, Hartmut Grasemann
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)