Article
Microbiology
Emma C. L. Marrs, Audrey Perry, John D. Perry
Summary: This study compared the efficacy of three commercially available selective media for the isolation of Burkholderia cepacia complex (BCC). The results showed that all three media were effective for BCC isolation, with BCSA being more selective than the other two media.
Article
Microbiology
Cedric Lood, Charlotte Peeters, Quentin Lamy-Besnier, Jeroen Wagemans, Daniel De Vos, Marijke Proesmans, Jean-Paul Pirnay, Fedoua Echahidi, Denis Pierard, Matthieu Thimmesch, Anca Boeras, Katrien Lagrou, Evelien De Canck, Elke De Wachter, Vera van Noort, Rob Lavigne, Peter Vandamme
Summary: The study found that Burkholderia multivorans, a pathogenic bacterium within the Burkholderia cepacia complex, primarily spreads among cystic fibrosis patients through environmental sources with rare cases of patient-to-patient transmission. Genomic analysis of an endemic strain infecting multiple patients revealed significant genomic diversity between patients, suggesting the presence of a microdiverse reservoir for this strain with active diversification. Additionally, the study identified specific genomic adaptations across multiple patients, indicating that the genomic background of a strain may dictate its route of adaptation within the cystic fibrosis lung.
Review
Immunology
Silvia A. Sousa, Antonio M. M. Seixas, Joana M. M. Marques, Jorge H. Leitao
Summary: This review discusses immunization and immunotherapy approaches against human infections caused by opportunistic pathogens such as Pseudomonas aeruginosa and Burkholderia cepacia complex. It covers vaccination strategies, ongoing clinical trials, as well as novel bacterial targets for development of immunization and immunotherapy strategies.
Review
Medicine, General & Internal
Freddy Frost, Matthew Shaw, Dilip Nazareth
Summary: This review examined the current evidence for long-term antibiotic therapy in people with CF and chronic BCC infection, finding insufficient evidence to determine an effective strategy for treating chronic BCC infection. The primary objective of the review was to assess the efficacy of treatments in terms of improvements in lung function and reductions in exacerbation rate, with secondary objectives including quantifying adverse events, mortality, and changes in quality of life associated with treatment.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Infectious Diseases
Frieder Schaumburg, Evgeny A. Idelevich, Alexander Mellmann, Barbara C. Kahl
Summary: Burkholderia cepacia complex (Bcc) in the airways of cystic fibrosis (CF) patients is associated with higher morbidity and mortality. This study assessed the susceptibility of Bcc to ceftazidime/avibactam and other standard drugs used for CF treatment, as well as identified the genomic determinants of resistance. The results showed that Bcc had a high susceptibility rate to ceftazidime/avibactam, while being less susceptible to other antibiotics.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Microbiology
Shekooh Behroozian, James E. A. Zlosnik, Wanjing Xu, Loretta Y. Y. Li, Julian E. Davies
Summary: There is a crisis in healthcare due to antibiotic-resistant bacteria, necessitating the search for novel antimicrobial agents. Kisameet clay has been found to inhibit acute infections, presenting a potential therapy. This offers hope for addressing the challenge of chronic bacterial infections and improving treatment options.
Article
Biotechnology & Applied Microbiology
Evelise Bach, Fernando Hayashi Sant'Anna, Guilherme Dubal dos Santos Seger, Luciane Maria Pereira Passaglia
Summary: This study performed pangenome analysis on Burkholderia sensu lato for the first time, and focused on the specific features of B. catarinensis in the pangenome of Burkholderia sensu stricto and Burkholderia cepacia complex (Bcc). The results showed great variability and unknown potential in these genomes. The genome of B. catarinensis contains genes related to hydmlase production and plant growth promotion.
Article
Agriculture, Dairy & Animal Science
Xiaona Wei, Wei Chen, Qianjin Sun, Qian Zhong, Zhuanqian Yan, Qingfeng Zhou, Yongchang Cao, Feng Chen, Xiangbin Zhang
Summary: In this study, it was found that among 487 suspected M. synoviae infection samples in China, 324 samples were positive, with a positive rate of 66.53%. A total of 104 strains were isolated and genotyped using the MLST method, and they belonged to 8 sequence types, with ST-34 being the most prevalent. BURST analysis showed that these 104 isolates were grouped together with 56 other strains isolated from China, indicating their similarity and independence from strains abroad.
Article
Respiratory System
Rianald Fischer, Carsten Schwarz, Rebecca Weiser, Eshwar Mahenthiralingam, Knut Smerud, Nils Meland, Hugo Flaten, Philip Rye
Summary: This study evaluated the safety and efficacy of inhaled OligoG as a therapy for CF patients with Bcc infection. The results showed a decrease in bacterial colony-forming units after OligoG treatment, although the difference was not statistically significant. There was no significant improvement in lung function parameters, but some quality of life scores showed relative improvement. The study suggests the potential of OligoG for the treatment of Bcc infection.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Microbiology
Min Yi Wong, Yuan-Hsi Tseng, Tsung-Yu Huang, Bor-Shyh Lin, Chun-Wu Tung, Chishih Chu, Yao-Kuang Huang
Summary: Burkholderia cepacia complex (BCC) is a group of closely related bacteria that are opportunistic pathogens causing nosocomial infections. Different species within the BCC complex can be accurately distinguished using MLST technology. The study revealed diverse bacterial species and sequence types within BCC, indicating high genetic diversity and potential clinical effects in different infections.
Article
Immunology
Tien-Hao Chang, Yu -Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng
Summary: This study investigated the clinical characteristics and outcomes of BCC bacteremic patients without cystic fibrosis. The findings suggest that no single regimen is associated with improved mortality, but selection of an appropriate antibiotic may provide better clinical outcomes among patients with BCC bacteremia.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Chemistry, Medicinal
Katerina Bendova, Vladislav Raclavsky, Radko Novotny, Dominika Luptakova, Miroslav Popper, Zbynek Novy, Marian Hajduch, Milos Petrik
Summary: Bacteria from the Burkholderia cepacia complex are generally considered non-pathogenic, but can cause serious infections in immunocompromised patients. This study developed a radiolabeled siderophore, ORNB, and demonstrated its effectiveness in positron emission tomography imaging for diagnosing Burkholderia infections. The radiolabeled complex showed optimal characteristics in vitro and accumulated at the site of infection in animal models. The results suggest that [Ga-68]-Ga-ORNB is a promising tool for diagnosing, monitoring, and evaluating therapeutic response to B. cepacia complex infection.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Dustin Maydaniuk, Bin Wu, Dang Truong, Sajani H. Liyanage, Andrew M. Hogan, Zhong Ling Yap, Mingdi Yan, Silvia T. Cardona
Summary: Bacteria of the genus Burkholderia, including pathogenic species, show intrinsic drug resistance. Auranofin analogs such as MS-40 and MS-40S exhibit antibiotic activity against Burkholderia clinical isolates, killing stationary-phase cells without inducing multistep resistance, and demonstrating low toxicity in model organisms. Further investigations are needed to explore the therapeutic potential of these compounds against Burkholderia infections.
Article
Microbiology
Leslie-Mariana Morales-Ruiz, Mariana Rodriguez-Cisneros, Jeniffer-Chris Kerber-Diaz, Fernando-Uriel Rojas-Rojas, J. Antonio Ibarra, Paulina Estrada-de los Santos
Summary: This study corrected the misclassification of B. servocepacia according to ICNP standards and renamed it as Burkholderia orbicola sp. nov. The original proposal of B. servocepacia was misleading as the name derived from Latin meaning "to protect/watch over" did not accurately reflect the opportunistic infection capability of the species.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biology
Andrew J. Hayes, Jessica M. Lewis, Mark R. Davies, Nichollas E. Scott
Summary: The study reveals that glycosylation in Burkholderia bacteria mainly targets Serine residues, and glycoproteins/glycosylation sites are highly conserved across Burkholderia isolates. This suggests that PglL enzymes are Serine-preferring oligosaccharyltransferases within the Burkholderia genus.
COMMUNICATIONS BIOLOGY
(2021)
