Article
Gastroenterology & Hepatology
Lorant Gonczi, Laszlo Lakatos, Zsuzsanna Kurti, Petra Golovics, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Peter L. Lakatos
Summary: This study conducted a prospective study on Crohn's disease patients in Hungary and found a high incidence rate, reflecting the era of biologic therapy in treatment strategies. The progression of disease behavior was low and long-term surgery rates had decreased.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Margaret L. P. Teng, Cheng Han Ng, Daniel Q. Huang, Kai En Chan, Darren J. H. Tan, Wen Hui Lim, Ju Dong Yang, Eunice Tan, Mark D. Muthiah
Summary: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease worldwide, with a higher incidence among males. The global prevalence of NAFLD among adults is 32%, and it has been increasing over time. The prevalence varies by world region, with the Americas and South-East Asia having the highest rates. If current trends continue, the prevalence of NAFLD is projected to increase significantly by 2030.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Amy L. Olson, Padmaja Patnaik, Nadine Hartmann, Rhonda L. Bohn, Elizabeth M. Garry, Laura Wallace
Summary: This study estimated the incidence and prevalence of fibrosing ILDs and chronic fibrosing ILDs with a progressive phenotype in the United States using a claims database, highlighting the high unmet need for treatment options in these diseases.
ADVANCES IN THERAPY
(2021)
Article
Gastroenterology & Hepatology
James D. Lewis, Lauren E. Parlett, Michele L. Jonsson Funk, Colleen Brensinger, Virginia Pate, Qufei Wu, Ghadeer K. Dawwas, Alexandra Weiss, Brad D. Constant, Maureen Mccauley, Kevin Haynes, Jeff Yufeng Yang, Douglas E. Schaubel, Andres Hurtado-Lorenzo, Michael David Kappelman
Summary: This study aimed to estimate the incidence, prevalence, and racial-ethnic distribution of physician-diagnosed inflammatory bowel disease (IBD) in the United States. Four administrative claims data sets were used, and corresponding estimates were obtained. The incidence of IBD remained relatively stable between the ages of 20 and 80, with variations in diagnosis rates among different races and ethnicities.
Article
Respiratory System
Toby M. Maher, Elisabeth Bendstrup, Louis Dron, Jonathan Langley, Gerald Smith, Javaria Mona Khalid, Haridarshan Patel, Michael Kreuter
Summary: IPF is a progressive lung disease with varying reported incidence and prevalence globally. Based on analyzed countries, estimated adjusted incidence and prevalence of IPF range from 0.09-1.30 and 0.33-4.51 per 10,000 persons, respectively. Future epidemiologic studies of IPF should account for age, sex, smoking status, and case definition specificity for consistency.
RESPIRATORY RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Yip Han Chin, Cheng Han Ng, Snow Yunni Lin, Sneha Rajiv Jain, Gwyneth Kong, Jeffery Wei Heng Koh, Darren Jun Hao Tan, David Eng Hui Ong, Mark Dhinesh Muthiah, Choon Seng Chong, Fung Joon Foo, Rupert Leong, Webber Pak Wo Chan
Summary: Upper gastrointestinal Crohn's disease (UGI-CD) is a significant subclassification of Crohn's Disease (CD) with a prevalence of 13%. It is most commonly found in the stomach and associated with concurrent ileocolonic involvement. Patients with L4-jejunal disease are more likely to require surgery.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Respiratory System
Ingrid A. Cox, Petr Otahal, Barbara Graaff, Tamera J. Corte, Yuben Moodley, Chris Zappala, Ian Glaspole, Peter Hopkins, Sacha Macansh, E. Haydn Walters, Andrew J. Palmer
Summary: This study utilized the MIAMOD method and software to estimate the mortality, incidence, and prevalence of IPF in Australia, with results showing an increase in these rates over the study period but a projected decrease in the future. The majority of IPF cases and deaths were found in individuals over 70 years old, with higher rates observed in males compared to females.
Article
Gastroenterology & Hepatology
Qiu-Yu Cai, Kun Tan, Xue-Li Zhang, Xu Han, Jing-Ping Pan, Zhi-Yin Huang, Cheng-Wei Tang, Jing Li
Summary: The incidence of CP in Sichuan Province, China is increasing, with an average annual incidence rate of 6.81 per 100000 person-years.The most common comorbidity in CP patients is diabetes. The number of CP-related hospitalizations and the hospitalization costs have been increasing over the years.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Valerie Crowell, Richard Houghton, Akanksha Tomar, Tricia Fernandes, Ferdinando Squitieri
Summary: Understanding the epidemiology of Huntington's disease is crucial for assessing disease burden and healthcare resource allocation. A model was developed and validated to estimate the diagnosed prevalence of the disease, with data from 8 countries indicating an estimated 66,787 individuals diagnosed with HD in 2020. The majority of patients were in less severe stages, with diagnosed prevalence rates varying between countries.
Article
Dermatology
Theofanis Zagoras, Rahime Inci, Despoina Kantere, Peter Holmstroem, Jenny Brostroem, Martin Gillstedt, Sam Polesie, Sirkku Peltonen
Summary: This retrospective registry-based cohort study aimed to estimate the incidence and prevalence of genodermatoses in the Swedish population and analyse healthcare usage. The study identified 73 unique genodermatosis diagnoses from the patient registry and verified the diagnoses using medical records. The incidence and prevalence of each diagnosis were calculated based on the nationwide cohort.
ACTA DERMATO-VENEREOLOGICA
(2023)
Review
Gastroenterology & Hepatology
Kiarash Riazi, Hassan Azhari, Jacob H. Charette, Fox E. Underwood, James A. King, Elnaz Ehteshami Afshar, Mark G. Swain, Stephen E. Congly, Gilaad G. Kaplan, Abdel-Aziz Shaheen
Summary: The prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) are significantly increasing worldwide, with higher rates in men compared to women. Greater awareness and cost-effective risk stratification strategies are needed to address the growing burden of NAFLD.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Rheumatology
Jeffrey A. Sparks, Yinzhu Jin, Soo-Kyung Cho, Seanna Vine, Rishi Desai, Tracy J. Doyle, Seoyoung C. Kim
Summary: This study investigated the prevalence, incidence, and cause-specific mortality of RA-associated interstitial lung disease (RA-ILD) among older US patients with RA. The results showed that RA-ILD was present or developed in nearly 5% of patients, and RA-ILD was associated with excess total, respiratory, and cancer mortality compared with RA without ILD.
Article
Gastroenterology & Hepatology
Jonathan P. Segal, Alan Askari, Susan K. Clark, Ailsa L. Hart, Omar D. Faiz
Summary: The study found that patients with inflammatory bowel disease are more likely to develop anal and cervical cancers compared to non-IBD patients, and have a lower survival rate.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Jonathan P. Segal, Alan Askari, Susan K. Clark, Ailsa L. Hart, Omar D. Faiz
Summary: This study demonstrates that patients with inflammatory bowel disease have a higher rate of anal and cervical cancers compared with the general population. Additionally, survival is poorer for anal cancers in the IBD group.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Dermatology
Retno Wahyuningsih, Robiatul Adawiyah, Ridhawati Sjam, Joedo Prihartono, Endah Ayu Tri Wulandari, Anna Rozaliyani, Robertus Ronny, Darma Imran, Mulyati Tugiran, Forman E. Siagian, David W. Denning
Summary: In Indonesia, an estimated 7.7 million people (2.89%) suffer from serious fungal infections annually. The incidence and prevalence of various fungal diseases vary, with cryptococcosis, Pneumocystis pneumonia, and candidaemia being among the most common.
Article
Gastroenterology & Hepatology
Anders Forss, Mark Clements, Par Myrelid, Hans Strid, Charlotte Soderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: This study demonstrates the long-term clinical effectiveness of ustekinumab in patients with active Crohn's disease, as well as its improvement in Health-related Quality of Life (HRQoL) measures.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Johanna Holmgren, Anna Froborg, Isabella Visuri, Jonas Halfvarson, Henrik Hjortswang, Pontus Karling, Par Myrelid, Ola Olen, Jonas F. Ludvigsson, Olof Grip
Summary: In patients with inflammatory bowel disease, the incidence rate of serious infection did not increase with the use of anti-TNF therapy and actually decreased more than 1 year after treatment initiation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jie Chen, Yajing Zhou, Yuhao Sun, Shuai Yuan, Rahul Kalla, Jing Sun, Jianhui Zhao, Lijuan Wang, Xuejie Chen, Xuan Zhou, Siqi Dai, Yu Zhang, Gwo-tzer Ho, Dajing Xia, Qian Cao, Zhanju Liu, Susanna C. Larsson, Xiaoyan Wang, Kefeng Ding, Jonas Halfvarson, Xue Li, Evropi Theodoratou, Jack Satsangi
Summary: This study identified 14 proteins associated with the risk of ulcerative colitis (UC) through the analysis of serum proteomic profiling data. Further analysis using Mendelian randomisation confirmed the causal relationship between two chemokines and the increased risk of UC. Additionally, a new protein associated with UC risk was identified. Reverse Mendelian randomisation analysis did not find any influence of genetic predisposition to UC on these three inflammation proteins.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Respiratory System
Maaike Giezeman, Josefin Sundh, Asa Athlin, Karin Lisspers, Bjorn Stallberg, Christer Janson, Scott Montgomery, Marta A. Kisiel, Anna Nager, Hanna Sandelowsky, Mikael Hasselgren
Summary: The study aimed to examine the association between comorbid heart disease and hospitalization and mortality in COPD patients. The findings showed that COPD patients with heart disease had a higher risk of hospitalization and mortality, mainly due to cardiovascular and other causes. Therefore, there is a need for strong primary and secondary prevention of cardiovascular disease in COPD patients.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Fang Fang, Ola Olen, Mingyang F. Song, Jonas Halfvarson, Bjorn Roelstraete, Hamed Khalili, Jonas Ludvigsson
Summary: In this study, individuals who underwent endoscopic biopsy with normal mucosa were followed up for a median of 10 years. The study found that these individuals had an elevated risk of inflammatory bowel disease (IBD) for at least 30 years. These findings imply the presence of a substantial symptomatic period before the diagnosis of IBD and emphasize the importance of considering the long-term risk of IBD in patients with symptoms but normal mucosa on gastrointestinal investigation.
Article
Gastroenterology & Hepatology
Aiva Lundberg Bave, Ola Olen, Jonas Soederling, Jonas F. Ludvigsson, Annika Bergquist, Caroline Nordenvall
Summary: Colectomy in UC patients was not associated with a decreased risk of subsequent PSC. The observed differences in the risk of PSC development over calendar periods are likely due to changes in PSC-diagnosis and UC-treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jamie M. Horrigan, Edouard Louis, Antonino Spinelli, Simon Travis, Bjorn Moum, Jessica Salwen-Deremer, Jonas Halfvarson, Remo Panaccione, Marla C. Dubinsky, Pia Munkholm, Corey A. Siegel
Summary: This study investigated the global use and barriers to using patient-reported outcomes (PROs) in clinical practice for inflammatory bowel disease (IBD). The majority of healthcare providers use PROs in clinical practice, but there are variations in which PROs are used and how they influence management. Barriers to using PROs include lack of familiarity, integration issues, and time constraints. Education about PROs and the use of an accepted set of PROs can help overcome these barriers and achieve global harmonization.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Joel Thunberg, Olle Granno, Daniel Bergemalm, Carl Eriksson, Isabella Visuri, Michael Eberhardson, Jonas Halfvarson
Summary: This study examined the agreement between a point-of-care test (POCT) by ProciseDx and the in-house enzyme-linked immunosorbent assay (ELISA) for infliximab (IFX) quantification. The results showed good agreement between the two methods, supporting the use of ProciseDx's POCT for rapid IFX quantification.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Medicine, General & Internal
Ferdinando D'Amico, Virginia Solitano, Fernando Magro, Pablo A. Olivera, Jonas Halfvarson, David Rubin, Axel Dignass, Sameer Al Awadhi, Taku Kobayashi, Natalia Sousa Freitas Queiroz, Marta Calvo, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese
Summary: As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. A global survey was conducted to shed light on physicians' knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption. Based on the survey results, a consensus was reached on key statements covering biosimilar effectiveness, safety, indications, rationale, multiple switches, therapeutic drug monitoring, non-medical switching, and future perspectives. The consensus affirmed that biosimilars are equally effective and safe compared to originator drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Yang Cao, Maximilian Peter Forssten, Babak Sarani, Scott Montgomery, Shahin Mohseni
Summary: This study developed a predictive model for in-hospital mortality in patients with severe traumatic brain injury using the machine learning algorithm XGBoost. The model achieved excellent predictive ability for patients with a length of stay up to 5 days, but performance decreased for patients with longer stays. Factors such as injury severity, Glasgow Coma Scale on admission, and patient's age were found to be important predictors.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Isabella Visuri, Carl Eriksson, Sara Karlqvist, Byron Lykiardopoulos, Per Karlen, Olof Grip, Charlotte Soderman, Sven Almer, Erik Hertervig, Jan Marsal, Carolina Malmgren, Jenny Delin, Hans Strid, Mats Sjoberg, Daniel Bergemalm, Henrik Hjortswang, Jonas Halfvarson
Summary: This study assessed the long-term outcomes of vedolizumab in treating inflammatory bowel disease. The results showed that vedolizumab had high continuation rates and was associated with improvements in clinical outcomes, health-related quality of life measures, and inflammatory markers at 2 and 3 years after treatment initiation.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, Daniel Bergemalm, Paulina A. Urbanowicz, Richard A. Gardner, Manfred IBD BIOM Consortium, Manfred Wuhrer, Jonas Halfvarson, Jack Satsangi, Daryl L. Fernandes, Daniel I. R. Spencer
Summary: This study investigated a composite serum N-glycomic biomarker to predict future disease course in newly diagnosed IBD patients. The biomarker showed a predictive capacity for treatment escalation in both the discovery and replication cohorts of patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Amiko M. Uchida, John J. Garber, Ashley Pyne, Kathryn Peterson, Bjorn Roelstraete, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: In this nationwide cohort study, EoE was found to be associated with a 3.5-fold increased risk of later IBD diagnosis, possibly due to genetic or early environmental risk factors.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)