Article
Microbiology
Heather Armstrong, Mandana Rahbari, Heekuk Park, David Sharon, Aducio Thiesen, Naomi Hotte, Ning Sun, Hussain Syed, Hiatem Abofayed, Weiwei Wang, Karen Madsen, Eytan Wine, Andrew Mason
Summary: Genetically manipulated mice lacking IL-10 have increased MMTV expression, which may contribute to the development of colitis. Antiviral therapy targeting MMTV reduces colonic MMTV RNA and improves colitis symptoms in these mice.
Article
Gastroenterology & Hepatology
Ziqing Ye, Lai Qian, Wenhui Hu, Shijian Miao, Yuhuan Wang, Junping Lu, Ying Zhou, Xiaolan Lu, Ye Zhang, Cuifang Zheng, Hua Sun, Wenjuan Tang, Zifei Tang, Song Sun, Kuiran Dong, Xiaowen Qian, Xiaowen Zhai, Ying Huang
Summary: This study retrospectively evaluated disease progression and clinical outcomes in 109 patients with interleukin-10 signalling deficiency. The results showed that there was no significant difference in survival probability between patients who received hematopoietic stem cell transplantation and those who did not. In non-transplanted patients, survival probability was significantly associated with perforation, ileus, and absence of thalidomide treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Qing Wang, Feifan Chen, Yingqiu Peng, Xuanyu Yi, Yu He, Yuan Shi
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestine characterized by maladjusted immune responses. Interleukin-27 (IL-27), a cytokine belonging to the superfamily of IL-6 and IL-12, has been found to play a dual regulatory role in immunological response. This review aims to summarize the new progress of the regulatory role of IL-27 in IBD and focus on its interaction with immune cells, providing evidence for potential IBD treatment mediated by IL-27.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
Romain Troubat, Samuel Leman, Katleen Pinchaud, Alexandre Surget, Pascal Barone, Sebastien Roger, Anne-Marie Le Guisquet, Bruno Brizard, Catherine Belzung, Vincent Camus
Summary: After exposure to UCMS, P2X7R KO mice showed significant differences in behavioral and neurogenesis compared to the control group, as well as notable changes in the density of brain immune cells. The recruitment rate of peripheral immune cells was unaffected by P2X7R gene expression or antidepressant treatment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Microbiology
Lola Holcomb, Johanna M. Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M. Mawe, Peter L. Moses, Emma Perry, Allesandra Stratigakis, Tao Zhang, Grace Chen, Suzanne L. Ishaq, Yanyan Li, Hiutung Chu
Summary: Crohn's disease is an inflammatory bowel disease that can be improved through diet and gut microbial interventions. However, there are still questions regarding the impact of IBD on gut microbial location and function, the effect of diet interventions on early life gut communities, and the role of biogeography in disease mediation.
Article
Immunology
Eliana Shaul, Maire A. Conrad, Noor Dawany, Trusha Patel, Megan C. Canavan, Alyssa Baccarella, Sarah Weinbrom, Daniel Aleynick, Kathleen E. Sullivan, Judith R. Kelsen
Summary: This study evaluated the clinical response to canakinumab in children with refractory very early onset inflammatory bowel disease (VEO-IBD). The results suggest that canakinumab may be an effective and safe treatment for VEO-IBD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen
Summary: The expression of TRAF6 is crucial for physiological processes. TRAF6[L74H] knock-in mice exhibit a distinct phenotype of autoimmunity and inflammation, which is different from TRAF6 KO mice. The inability to signal via TNF Receptor Superfamily members may explain the different phenotypes observed in TRAF6-deficient mice.
Article
Chemistry, Multidisciplinary
Jingang Liu, He Ren, Chen Zhang, Jiexin Li, Qian Qiu, Nan Zhang, Ning Jiang, Jonathan F. Lovell, Yumiao Zhang
Summary: A nested delivery system for orally taking the anti-inflammatory cytokine IL-10 for the treatment of inflammatory bowel disease (IBD) is developed. Compared with intravenous or intramuscular administration routes, this new method for orally taking protein has high patient compliance. This study also provides a versatile methodology for other oral protein-based therapeutics delivery.
Article
Immunology
Anna Carrasco, Eva Tristan, Fernando Fernandez-Banares, Albert Martin-Cardona, Montserrat Aceituno, Yamile Zabana, Lourdes Fluvia, Jose Maria Hernandez, Violeta Loren, Josep Manye, Antonio Salas, Xavier Andujar, Carme Loras, Maria Esteve
Summary: This study found abnormal levels of IL-10 in both mucosa and blood in patients with active Crohn's disease, suggesting its potential clinical applications in predicting outcomes.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Gastroenterology & Hepatology
Jia-Jia Lv, Wen Su, Xiao-Yan Chen, Yi Yu, Xu Xu, Chun-Di Xu, Xing Deng, Jie-Bin Huang, Xin-Qiong Wang, Yuan Xiao
Summary: Mutation of the IL10RA gene was identified in all four patients with VEO-IBD, with a novel 333-bp deletion found through whole-genome sequencing. This deletion was associated with abnormal serum IL-10 levels and impaired immune response in patient samples.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
Yangke Cai, Xuan Jia, Liyi Xu, Hanwen Chen, Siyuan Xie, Jianting Cai
Summary: This study used Mendelian Randomization analysis to confirm the causal associations between different subtypes of IL-17 and inflammatory bowel disease (IBD). IL-17B, IL-17E, and IL-17RB were found to be significantly associated with an increased risk of ulcerative colitis (UC), while IL-17C and IL-17RC showed causal effects on the increased risk of Crohn's disease (CD).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Genetics & Heredity
Adam J. Lawther, Jerzy Zieba, Zhiming Fang, Teri M. Furlong, Illya Conn, Hemna Govindaraju, Laura L. Y. Choong, Nigel Turner, Khawar Sohail Siddiqui, Wallace Bridge, Sam Merlin, Tzipi Cohen Hyams, Murray Killingsworth, Valsamma Eapen, Raymond A. Clarke, Adam K. Walker
Summary: Mitochondrial dysfunction is strongly associated with autism spectrum disorder (ASD), and the IMMP2L gene is linked to autism inheritance. By developing an Immp2lKD knockout mouse model, the researchers found that Immp2l(KD) -/- KO mice did not show any differences in the core behavioral symptoms of ASD, but they exhibited increased auditory stimulus-driven instrumental behavior and amphetamine-induced locomotion. The researchers also discovered that the ROS levels were lowered in the new Immp2l(KD) -/- KO mice, contrary to previous studies on Immp2l-deficient mouse models, and these mice did not display oxidative stress-related phenotypes.
Article
Pharmacology & Pharmacy
Lanlan Chen, Zhongqi Fan, Xiaodong Sun, Wei Qiu, Yuguo Chen, Jianpeng Zhou, Guoyue Lv
Summary: This Mendelian randomization (MR) study suggests that there is no causal relationship between IBD and NAFLD. Therapeutics targeting NAFLD may not work for IBD and vice versa, as genetically-elevated risk of IBD might cause liver fat accumulation but no causal effect of NAFLD on IBD was observed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kristine Holgersen, Ross Dobie, Colin Farquharson, Rob van't Hof, Syed Faisal Ahmed, Axel Kornerup Hansen, Thomas L. Holm
INFLAMMATORY BOWEL DISEASES
(2015)
Article
Gastroenterology & Hepatology
Kristine Holgersen, Burak Kutlu, Brian Fox, Kyle Serikawa, James Lord, Axel Kornerup Hansen, Thomas Lindebo Holm
JOURNAL OF CROHNS & COLITIS
(2015)
Article
Gastroenterology & Hepatology
Thomas Lindebo Holm, Ditte Tornehave, Henrik Sondergaard, Peter Helding Kvist, Bodil-Cecilie Sondergaard, Lene Hansen, Mette Brunsgaard Hermit, Kristine Holgersen, Sandra Vergo, Klaus Stensgaard Frederiksen, Claus Haase, Dorthe Lundsgaard
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2018)
Article
Immunology
Kristine Holgersen, Peter Helding Kvist, Axel Kornerup Hansen, Thomas Lindebo Holm
INTERNATIONAL IMMUNOPHARMACOLOGY
(2014)
Article
Gastroenterology & Hepatology
Jakob Benedict Seidelin, Mehmet Coskun, Peter Helding Kvist, Thomas Lindebo Holm, Kristine Holgersen, Ole Haagen Nielsen
JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Pediatrics
Kristine Holgersen, Xiaoyan Gao, Rangaraj Narayanan, Tripti Gaur, Galen Carey, Norman Barton, Xiaoyu Pan, Tik Muk, Thomas Thymann, Per Torp Sangild
Summary: Supplemental rhIGF-1/BP-3 did not negatively affect any of the measured variables of clinical status or gut maturation in preterm pigs. Longer-term safety and efficacy of exogenous rhIGF-1/BP-3 to support maturation of the gut and other critical organs in preterm newborns remain to be investigated in both pigs and infants.
FRONTIERS IN PEDIATRICS
(2021)