Article
Gastroenterology & Hepatology
Firas Rinawi, Amanda Ricciuto, Peter C. Church, Karen Frost, Eileen Crowley, Thomas D. Walters, Anne M. Griffiths
Summary: The study found that early use of adalimumab (ADA) in patients in weeks 4 and 8 were associated with clinical and biomarker remission at week 24, with higher ADA levels leading to superior outcomes.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Laura Sirmai, Anne-Laure Pelletier, Nathalie Gault, Camille Zallot, Guillaume Bouguen, Dominique Bouchard, Pascale Roland Nicaise, Marine Peyneau, Sandrine Sironneau, Marcelo De Carvalho Bittencourt, Antoine Petitcollin, Pedro Fernandez, Xavier Roblin, Laurent Siproudhis, Laurent Abramowitz
Summary: There is a significant association between high serum adalimumab concentrations and clinical remission of CD-associated perianal fistulas.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Elisa Buffone, So Jeong Lee, Parambir S. Dulai, John K. Marshall, Walter Reinisch, Neeraj Narula
Summary: The study found that early symptoms of pain and stool frequency in Crohn's disease patients after induction therapy with infliximab are related to long-term clinical remission but not endoscopic remission. Clinical symptoms alone should not be relied upon for assessing the response to therapies for Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Parambir S. Dulai, John K. Marshall, Vipul Jairath, Walter Reinisch, Neeraj Narula
Summary: Disease duration of less than 5 years is associated with clinical remission at the end of induction in Crohn's disease patients. Strategies to reduce placebo response rates in clinical trials should consider stratification or exclusion based on disease duration and mild disease severity as measured by objective biomarkers.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Medicine, Research & Experimental
Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang, Xiaoyong Song
Summary: Adalimumab is more effective than placebo in inducing clinical response/remission in patients with Crohn's disease, but more research is needed to confirm its safety.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Martin Mcdonnell, Stephanie Sartain, Catherine Westoby, Vasiliki Katarachia, Stephen A. Wootton, J. R. Fraser Cummings, Roberto Iacone
Summary: This systematic review examines the prevalence of micronutrient insufficiency in adults with Crohn's disease in clinical remission. Vitamins D and B12 were found to be the most frequently reported nutrients with low levels. There is substantial evidence for micronutrient deficiency in Crohn's disease patients, particularly in Vitamins D and B12.
Article
Gastroenterology & Hepatology
Torsten Kucharzik, Rune Wilkens, Maria-Antonietta D'agostino, Giovanni Maconi, Manuela Le Bars, Marjolein Lahaye, Ivana Bravata, Maciej Nazar, Lioudmila Ni, Elena Ercole, Mariangela Allocca, Nadezda Machkova, Floris A. E. de Voogd, Carolina Palmela, Rose Vaughan, Christian Maaser
Summary: In this study, ustekinumab was found to be effective in reducing bowel inflammation in patients with moderate-to-severe Crohn's disease. The use of intestinal ultrasound as a noninvasive imaging procedure provided valuable insights into the treatment response. Colonic involvement and biologic-naive status were associated with better outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fenna M. Jansen, Reinier C. A. van Linschoten, Wietske Kievit, Lisa J. T. Smits, Renske W. M. Pauwels, Dirk J. de Jong, Annemarie C. de Vries, Paul J. Boekema, Rachel L. West, Alexander G. L. Bodelier, Ingrid A. M. Gisbertz, Frank H. J. Wolfhagen, Tessa E. H. Romkens, Maurice W. M. D. Lutgens, Adriaan A. van Bodegraven, Bas Oldenburg, Marieke J. Pierik, Maurice G. V. M. Russel, Nanne K. de Boer, Rosalie C. Mallant-Hent, Pieter C. J. ter Borg, Andrea E. van der Meulen-de Jong, Jeroen M. Jansen, Sita Jansen, Adrianus C. I. T. L. Tan, Frank Hoentjen, C. Janneke van der Woude
Summary: This study aimed to assess the cost-effectiveness of increasing adalimumab dose intervals compared to the conventional dosing interval in patients with Crohn's disease in stable clinical and biochemical remission. The results showed no difference in utility and total costs between the two groups over the 48-week study period. However, increasing adalimumab dose intervals was more likely to be cost-effective at willingness to accept levels below €53,960 per quality-adjusted life year.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Samuel Raimundo Fernandes, Juliana Serrazina, Ines Ayala Botto, Tiago Leal, Andreia Guimaraes, Joana Lemos Garcia, Isadora Rosa, Rita Prata, Diana Carvalho, Joao Neves, Pedro Campelo, Sofia Ventura, Andrea Silva, Mariana Coelho, Cristiana Sequeira, Ana Paula Oliveira, Francisco Portela, Paula Ministro, Helena Tavares de Sousa, Jaime Ramos, Isabel Claro, Raquel Goncalves, Luis Araujo Correia, Rui Tato Marinho, Helena Cortez Pinto, Fernando Magro
Summary: This study suggests that achieving transmural remission, isolated endoscopic remission, and isolated radiologic remission can improve clinical outcomes within 5 years in patients with CD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Nutrition & Dietetics
Martyna Szczubelek, Karolina Pomorska, Monika Korolczyk-Kowalczyk, Konrad Lewandowski, Magdalena Kaniewska, Grazyna Rydzewska
Summary: Exclusive enteral nutrition (EEN) and Crohn's disease exclusion diet (CDED) are both effective in inducing remission in pediatric CD patients. The study demonstrates that CDED is equally effective in adult CD patients, with 76.7% achieving clinical remission after 6 weeks.
Article
Urology & Nephrology
Mark Canney, Sean J. Barbour, Yuyan Zheng, Rosanna Coppo, Hong Zhang, Zhi-Hong Liu, Keiichi Matsuzaki, Yusuke Suzuki, Ritsuko Katafuchi, Heather N. Reich, Daniel Cattran
Summary: Findings suggest that proteinuria reduction can serve as a surrogate outcome in IgA nephropathy, and quantifying the duration of proteinuria remission is valuable when estimating the risk of hard clinical endpoints.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Takahiro Miyazu, Natsuki Ishida, Ryosuke Takano, Satoshi Tamura, Mihoko Yamade, Yasushi Hamaya, Shinya Tani, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Summary: The Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) is a useful tool in evaluating mucosal lesions in patients with small intestinal CD in clinical remission and can help assess the need for additional treatment, including those who undergo intestinal resection.
Article
Gastroenterology & Hepatology
Eran Zittan, A. Hillary Steinhart, Pavel Goldstein, Raquel Milgrom, Ian M. Gralnek, Mark S. Silverberg
Summary: The study found that higher adalimumab drug levels (>13.9 μg/mL) at week 4 were significantly associated with biological remission at week 24 in patients with Crohn's disease.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Lauren Collen
Summary: A pediatric patient with refractory Crohn's disease achieved rapid remission with upadacitinib, which is the first successful use of this drug in pediatric inflammatory bowel disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Keiichi Haga, Tomoyoshi Shibuya, Taro Osada, Shunsuke Sato, Yuka Fukuo, Osamu Kobayashi, Toshio Yamada, Daisuke Asaoka, Kentaro Ito, Kei Nomura, Mayuko Haraikawa, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Dai Ishikawa, Mariko Hojo, Akihito Nagahara
Summary: This study found that VDZ is effective in the majority of UC patients, with a high rate of mucosal healing even in those who have previously failed biological therapy. Early clinical remission can predict long-term remission, and week 6 can be a useful evaluation point when using VDZ for UC treatment.