期刊
JOURNAL OF CROHNS & COLITIS
卷 7, 期 5, 页码 E164-E170出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2012.07.032
关键词
Crohn's disease; Cholecystectomy; Complications; Inflammatory bowel disease; Ulcerative colitis
Background and aim: Our previous single-center study showed that patients with underlying inflammatory bowel disease (IBD) had a higher risk for post-cholecystectomy complications. The aim of the current population-based study was to verify whether concomitant IBD was indeed associated with an increased risk of post-cholecystectomy complications. Methods: In this cross-sectional study, all 1,155,432 patients from the Nationwide Inpatient Sample (NIS) with a primary procedure of cholecystectomy were examined, and 5891 patients with IBD were compared with 1,149,541 patients without IBD from 2006 to 2008. Results: There were no significant differences in age, gender, frequency of obesity, and postoperative mortality between the two groups. More patients in the IBD group had post-operative complications than the non-IBD group [398/5891 (6.8%) vs. 55,202/1,149,541 (4.8%), p=0.002)]. On multivariate analysis, the presence of Crohn's disease (CD) was associated with an increased risk for post-operative complications (odds ratio [OR] =1.6; 95% confidence interval [CI], 1.2 2.1, p=0.003). The other risk factors for post-cholecystectomy complications were older age, male gender, African-American race, malnutrition and patients with higher co-morbidity index. The presence of ulcerative colitis (UC) was associated with a trend for increased complications (OR= 1.3, 95% CI 0.8-2.1, p=0.08). Patients with IBD who underwent cholecystectomy incurred higher mean hospital costs ($39,651 vs. $35,196, p=0.006) and also stayed in the hospital 1.2 days longer than those without underlying IBD. Conclusions: CD patients undergoing cholecystectomy were shown to have a significantly increased risk for postoperative complications, have a longer stay in the hospital, and incur higher hospitalization costs. (C) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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