期刊
JOURNAL OF CROHNS & COLITIS
卷 6, 期 4, 页码 470-475出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2011.10.005
关键词
Bowel perforation; Colonoscopy; Inflammatory bowel disease; Ulcerative colitis; Crohn's disease
Background and aim: Colonoscopic perforation is a rare complication. We sought to determine its risk factors in patients with inflammatory bowel disease (IBD). Materials and methods: The study group consisted of 19 IBD patients who had perforation secondary to diagnostic or therapeutic colonoscopy from January 2002 to October 2010. The control group consists of 76 IBD patients undergoing colonoscopy and no perforations that were matched based on indication in a 4:1 ratio to the study group. Demographic and clinical variables as well as perforation outcomes were analyzed by univariate and multivariate analyses. Results: There were a total of 5295 colonoscopies done during the study period in IBD patients of which 19 patients had perforation. The prevalence of perforation in IBD patients was 0.3%. Of the 19 patients, 12 had Crohn's disease (CD) and 7 had ulcerative colitis (UC). Patients in the perforation group were more likely treated with steroids (68.4% vs. 21.1%, p<0.001) and had severe disease on endoscopy (31.6% vs. 10.1%, p = 0.03) than that in the control groups. On multivariate analysis, severe disease on endoscopy (adjusted odds ratio [aOR] = 3.82, 95% confidence interval [CI] = 1.03-15.24) and steroid treatment (aOR = 7.68; 95% CI = 1.48, 39.81) were independently associated with the risk of perforation. The median length of stay in the perforation group was 10 days (range 2-23 days). There was no mortality in our study. Conclusions: There appears to be a higher risk of colonoscopy-associated perforation in IBD patients with active disease and on steroids. (C) 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据