Article
Gastroenterology & Hepatology
Garth R. Swanson, Mary Biglin, Hannah Raff, Vijit Chouhan, Sarah Jochum, Maliha Shaikh, Lauren Francey, Faraz Bishehsari, John Hogenesch, Ali Keshavarzian
Summary: Chronotherapy is a method of timing medication to optimize drug efficacy and minimize toxicity according to the biological rhythms of the host. This study found that morning dosing resulted in better metabolite profiles, and host chronotype could help identify patients who would benefit from evening dosing.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2023)
Review
Environmental Sciences
Oliwia Zakerska-Banaszak, Liliana Lykowska-Szuber, Michal Walczak, Joanna Zuraszek, Aleksandra Zielinska, Marzena Skrzypczak-Zielinska
Summary: The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) has been confirmed for more than 50 years. Despite controversies over their cytotoxic properties and adverse effects, thiopurines are still widely used for maintaining remission in Crohn's disease and ulcerative colitis. Further research is needed to explore the modulation of thiopurine action in combination therapy and their interaction with the gut microbiota.
Review
Pharmacology & Pharmacy
Andrea Cassinotti, Francesco Passamonti, Sergio Segato
Summary: Cell-based therapies have been explored in immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD). The most studied treatment in IBD involves stem cells, with recent studies also focusing on regulatory cells such as T-reg and Tr1 cells. Preclinical research is also being conducted on induced pluripotent stem cells in animal models related to colitis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pediatrics
Eirini Giannoudaki, Siobhan Gargan, Seamus Hussey, Aideen Long, Patrick T. Walsh
Summary: T cell subsets play crucial roles in pediatric inflammatory bowel disease, and targeting their infiltration may represent a novel treatment approach.
FRONTIERS IN PEDIATRICS
(2021)
Article
Oncology
Wei Song, Haixi Zhang, Fan Yang, Kiichi Nakahira, Cheng Wang, Keqian Shi, Ruoyu Zhang
Summary: In this study, the researchers generated the first single cell landscape for hepatosplenic T-cell lymphoma (HSTCL) and characterized the molecular pathogenesis underlying the disease progression. They found unique gene expressing signatures in malingnant gamma delta T cells of HSTCL and discovered two transcriptionally distinct tumor subtypes during the disease progression.
Article
Gastroenterology & Hepatology
Stefan Schreiber, Shomron Ben-Horin, Jaroslaw Leszczyszyn, Robert Dudkowiak, Adi Lahat, Beata Gawdis-Wojnarska, Aldis Pukitis, Marek Horynski, Katalin Farkas, Jaroslaw Kierkus, Maciej Kowalski, Sang Joon Lee, Sung Hyun Kim, Jee Hye Suh, Mi Rim Kim, Seul Gi Lee, Byong Duk Ye, Walter Reinisch
Summary: This study demonstrated the pharmacokinetic noninferiority of CT-P13 SC to CT-P13 IV, with comparable clinical remission rates between the two formulations.
Review
Biochemistry & Molecular Biology
Raquel Gomez-Bris, Angela Saez, Beatriz Herrero-Fernandez, Cristina Rius, Hector Sanchez-Martinez, Jose M. Gonzalez-Granado
Summary: Inflammatory bowel disease (IBD) refers to chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, presenting as Crohn's disease (CD) or ulcerative colitis (UC). It is characterized by exacerbated innate and adaptive immunity in the gut, along with microbiota dysbiosis and disruption of the intestinal barrier, leading to increased bacterial exposure. CD4 T-cells play a crucial role in the development of IBD, with various phenotypes and interactions with other immune cells determining the progression of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Dominique Bron, Laurence De Leval, Sandra Michiels, Sebastian Wittnebel
Summary: Hepatosplenic lymphoma (HSTCL) is a rare T-cell malignancy with poor survival in young males, but recent studies suggest that allogeneic transplantation and specific chemotherapy may be effective treatment options. Recent molecular studies have identified potential targets for new therapeutic strategies.
CURRENT OPINION IN ONCOLOGY
(2021)
Article
Oncology
Qian Wang, Yibin Jiang, Qian Zhu, Yishan Duan, Xiaochen Chen, Ting Xu, Zhengming Jin, Caixia Li, Depei Wu, Haiwen Huang
Summary: HSTCL typically presents with splenomegaly, hepatomegaly, and B symptoms. Some patients respond to chemotherapy, with those receiving allogeneic hematopoietic cell transplantation having a survival time ranging from 10 to 27 months. Intensive induction chemotherapy followed by HSCT may improve the prognosis of HSTCL.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lauren J. Mohan, Jacqueline S. Daly, Barbara M. Ryan, Zebunnissa Ramtoola
Summary: This study investigated the potential of nanomedicines in the treatment of inflammatory bowel diseases (IBD). The results showed that the size of nanoparticles can modulate the targeting effect on the intestinal epithelial barrier, delivering the drug directly to the inflamed tissue and reducing inflammation and cytotoxicity.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Hematology
Youngkyung Jeon, Sang Eun Yoon, Junhun Cho, Seok Jin Kim, Won Seog Kim
Summary: Hepatosplenic T cell lymphoma (HSTCL) is a rare and aggressive lymphoma with no standard treatment and poor treatment response. Most patients present with B symptoms, hepatomegaly, and splenomegaly. In general, HSTCL has a poor prognosis and requires further research on genetic and biological information.
ANNALS OF HEMATOLOGY
(2023)
Article
Medical Laboratory Technology
Sofia A. W. van Moorsel, Debbie S. Deben, Rob H. Creemers, Bjorn Winkens, Paul Bus, Marieke J. Pierik, Melek Simsek, Nanne K. H. de Boer, Adriaan A. van Bodegraven, Dennis R. Wong
Summary: This study aimed to validate and optimize predictive algorithms for thiopurine-associated hepatotoxicity, but found limited accuracy in predicting liver toxicity. Factors contributing to this outcome included changes in prescription behavior over time and lower dosages of MP being prescribed.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Medicine, General & Internal
Yajun Li, Kailin Chen, Chaohui Zuo, Ruolan Zeng, Yizi He, Xiaoyan Chen, Ling Xiao, Hui Zhou
Summary: This study retrospectively reviewed 123 patients with HSTCL diagnosed between 1975 and 2016 in the SEER database, and found that young patients and a strong male predominance were more common in HSTCL. The overall survival of HSTCL patients was similar to PTCL-NOS patients, but worse than ALK+ ALCL patients, and chemotherapy combined with topical treatment may improve survival rates. Further studies are needed to better understand and treat this rare and unfavorable disease.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Immunology
Minhao Yu, Hui Ding, Shuai Gong, Yang Luo, Haiping Lin, Yifei Mu, Hao Li, Xiaobo Li, Ming Zhong
Summary: This study found that intestinal fungi play a role in regulating immune responses in inflammatory bowel disease (IBD). Antibiotic-mediated depletion of fungi facilitated IBD development. Fungi enhance oxidative phosphorylation (OXPHOS) by enhancing glutaminolysis. Mechanistically, fungi activate the dectin-1-Syk-NF-kappa B signaling pathway to promote the expression of key enzymes and transporters involved in glutaminolysis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Engineering, Biomedical
Kai Jiang, Xiangjing Cao, Haitao Wu, Yifeng Xu, Lulu Liu, Haisheng Qian, Zhaohua Miao, Hua Wang, Yan Ma
Summary: Pluronic F-127-coated tungsten diselenide (WSe2@F127) nanozymes effectively alleviate inflammatory bowel disease by eliminating reactive oxygen/nitrogen species, modulating gut microbiota, and remodeling the immune barrier.
ADVANCED HEALTHCARE MATERIALS
(2023)