Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke

Purpose: High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods: Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year. Results: Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score. Conclusion: Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke. (C) 2013 Elsevier Inc. All rights reserved.