Review
Biochemistry & Molecular Biology
Ahlam Fatmi, Wiam Saadi, Jesus Beltran-Garcia, Jose Luis Garcia-Gimenez, Federico Pallardo
Summary: Sepsis in newborns, especially preterm-born neonates, carries a significant risk of morbidity and mortality. Endothelial glycocalyx (eGC) shedding is an essential pathophysiological process in sepsis, contributing to microvascular dysfunction and organ failure. These processes have been extensively studied in adults, but are poorly understood in neonatal sepsis. Further research is needed to understand the composition, development, and mechanisms of eGC disruption in neonates, and to explore eGC dysfunction as a diagnostic and prognostic biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Erik H. A. Michels, Joe A. Butler, Tom D. Y. Reijnders, Olaf Cremer, Brendon M. Scicluna, Fabrice Uhel, Hessel F. Peters-Sengers, Marcus Schultz, Julian E. Knight, Lonneke van Vught, Tom M. van der Poll
Summary: This study provides evidence that older age is associated with attenuated endothelial cell activation and dysfunction in sepsis, as well as impaired immune and cytokine signaling based on blood leukocyte transcriptome analysis. These findings suggest that age should be considered when selecting patients for sepsis trials targeting the immune system or endothelial cell response.
Review
Medicine, General & Internal
Eric K. Patterson, Gediminas Cepinskas, Douglas D. Fraser
Summary: The endothelial glycocalyx is an important component of the endothelial barrier. Its degradation or removal in critical illnesses can lead to endothelial dysfunction and complications. Current research focuses on understanding its components, degradation mechanisms, and strategies for protection and rebuilding.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chaeyeong Kim, Hyunchae Sim, Jong-Sup Bae
Summary: This study found that benzoylpaeoniflorin (BPF) has a mitigating effect on LPS-induced septic conditions and can protect mice from sepsis caused by cecal ligation and puncture (CLP). In addition, BPF inhibits the expression of key pro-inflammatory molecules in LPS-induced inflammatory cells and suppresses the phosphorylation levels of NF-κB and MAPKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Sarah Gaudette, Lisa Smart, Andrew P. Woodward, Claire R. Sharp, Dez Hughes, Simon R. Bailey, Julien R. S. Dandrieux, Leilani Santos, Manuel Boller
Summary: Naturally occurring sepsis and organ dysfunction in dogs were associated with increased endothelial activation and inflammatory response, as indicated by elevated concentrations of biomarkers such as VEGF, HA, PAI-1, and vWF, and inflammatory mediators IL-6, IL-8, IL-10, C-reactive protein, and monocyte chemoattractant protein-1.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Physiology
Lichun Wang, Eleftheria Letsiou, Huashan Wang, Patrick Belvitch, Lucille N. Meliton, Mary E. Brown, Mounica Bandela, Jiwang Chen, Joe G. N. Garcia, Steven M. Dudek
Summary: This study investigated the efficacy of FTY720 S-phosphonate (Tys) in protecting against lung endothelial barrier disruption induced by methicillin-resistant Staphylococcus aureus (MRSA). The results demonstrated that Tys effectively protected lung endothelial cells from barrier disruption and attenuated MRSA-induced inflammatory signaling in vitro. In vivo experiments further showed that Tys reduced lung permeability and levels of inflammatory cells in response to MRSA, indicating its potential as a therapeutic strategy for ARDS.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Peripheral Vascular Disease
Leslie Marisol Lugo-Gavidia, Dylan Burger, Vance B. Matthews, Janis M. Nolde, Marcio Galindo Kiuchi, Revathy Carnagarin, Dennis Kannenkeril, Justine Chan, Anu Joyson, Lakshini Y. Herat, Omar Azzam, Markus P. Schlaich
Summary: Microparticles are small cell vesicles derived from the cell membrane, with growing evidence linking them to cardiovascular disease through inflammation, endothelial function, and thrombosis. Research on the direct causal link between microparticle release and their implications on physiological and pathological conditions is ongoing.
Article
Respiratory System
Jos F. Frencken, Maarten van Smeden, Kirsten van de Groep, David S. Y. Ong, Peter M. C. Klein Klouwenberg, Nicole Juffermans, Marc J. M. Bonten, Tom van der Poll, Olaf L. Cremer
Summary: In this study, the authors assessed the correlations between high-sensitivity cardiac troponin I and inflammation, coagulation, and endothelial function in patients with sepsis. Structural equation modeling analysis found that activated coagulation was associated with elevated troponin levels, while hyperinflammation and endothelial dysfunction were not.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, General & Internal
Dakota Gustafson, Michelle Ngai, Ruilin Wu, Huayun Hou, Alice Carvalhal Schoffel, Clara Erice, Serena Mandla, Filio Billia, Michael D. Wilson, Milica Radisic, Eddy Fan, Uriel Trahtemberg, Andrew Baker, Chris McIntosh, Chun-Po S. Fan, Claudia C. dos Santos, Kevin C. Kain, Kate Hanneman, Paaladinesh Thavendiranathan, Jason E. Fish, Kathryn L. Howe
Summary: This study prospectively evaluated circulating inflammatory, cardiac, and endothelial cell activation markers in COVID-19 patients and identified microRNA and vascular biomarkers that are prognostic of in-hospital mortality. The study also found that COVID-19 patient plasma can cause endothelial barrier dysfunction, which can be improved with therapeutic interventions.
Article
Critical Care Medicine
Valentino D'Onofrio, Dries Heylen, Murih Pusparum, Inge Grondman, Johan Vanwalleghem, Agnes Meersman, Reinoud Cartuyvels, Peter Messiaen, Leo A. B. Joosten, Mihai G. Netea, Dirk Valkenborg, Gokhan Ertaylan, Inge C. Gyssens
Summary: This study aimed to identify biomarkers of inflammation for the diagnosis and prognosis of infection in patients with suspected sepsis. The results showed that compared to patients with bacterial infections, patients with viral infections had lower levels of certain proteins in circulation. Additionally, higher expression levels of certain proteins were observed in patients with high SOFA scores and worse outcomes. These inflammatory proteins are mainly involved in pathways known to be activated early in the inflammatory response. Unsupervised hierarchical clustering analysis confirmed that inflammatory response was more strongly related to disease severity than to aetiology.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Elena Dolmatova, Steven J. Forrester, Keke Wang, Ziwei Ou, Holly C. Williams, Giji Joseph, Sandeep Kumar, Alejandra Valdivia, Andrew P. Kowalczyk, Hongyan Qu, Hanjoong Jo, Bernard Lassegue, Marina S. Hernandes, Kathy K. Griendling
Summary: The study demonstrates that Poldip2 plays a significant role in regulating endothelial function during sepsis-induced lung injury, and its specific inhibition could have clinical benefits.
CARDIOVASCULAR RESEARCH
(2022)
Review
Immunology
Julia Faura, Alejandro Bustamante, Francesc Miro-Mur, Joan Montaner
Summary: Stroke-induced immunosuppression increases the risk of stroke-associated infections in stroke patients, particularly stroke-associated pneumonia, but there are currently no accurate biomarkers for early diagnosis and prevention. Efforts are being made to explore local immunomodulation as a potential approach for preventive therapy of stroke-associated pneumonia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Katrin Laakmann, Jorina Mona Eckersberg, Moritz Hapke, Marie Wiegand, Jeff Bierwagen, Isabell Beinborn, Christian Preusser, Elke Pogge von Strandmann, Thomas Heimerl, Bernd Schmeck, Anna Lena Jung
Summary: Blood stream bacterial extracellular vesicles (bEVs) from gram-negative, sepsis-associated bacteria reduce the expression of vascular protective factor RNase1, leading to endothelial cell dysfunction. This finding opens up new avenues for therapeutic intervention of EC dysfunction by promoting RNase1 integrity.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Nayeon Kim, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae
Summary: CN can suppress excessive permeability induced by HMGB1 and improve vascular instability by inhibiting the release of HMGB1, leading to an increased survival rate in a mouse model of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Carlo Pietrasanta, Andrea Ronchi, Claudia Vener, Chiara Poggi, Claudia Ballerini, Lea Testa, Rosaria Maria Colombo, Elena Spada, Carlo Dani, Fabio Mosca, Lorenza Pugni
Summary: This study aimed to evaluate the accuracy of presepsin for diagnosing and early stratifying neonates with suspected sepsis. Presepsin showed potential value in diagnosing neonatal sepsis and septic shock, but had limited support in early identification of neonates with positive blood culture.
Article
Public, Environmental & Occupational Health
Adeniyi J. Idigo, Matthew L. Brown, Howard W. Wiener, Russell L. Griffin, Yuanfan Ye, Amrita Mukherjee, Allen W. Bryan, Rachael A. Lee, Sadeep Shrestha
Summary: There was an overall increase in the use of third- and fourth-generation cephalosporins after fluoroquinolone preauthorization was implemented, but there was no observed increase in non-susceptibility to these antibiotics.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Rehabilitation
Cristina Shea, Chloe Slocum, Richard Goldstein, Mary Joan Roach, Russell Griffin, Yuying Chen, Ross Zafonte
Summary: This study aimed to investigate whether initial emergency department physiological measures and trauma severity predict functional outcomes and neurologic recovery in traumatic spinal cord injury. The results showed that emergency department physiological parameters did not predict functional outcomes in this cohort.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Dermatology
Eugen Stancut, Olivia G. Melvin, Russell L. Griffin, Carlton B. Phillips, Conway C. Huang
Summary: This study aimed to evaluate institutional adherence to appropriate use criteria for Mohs micrographic surgery (MMS) and found high adherence but also some instances of inappropriate treatment, primarily due to treating adjacent lesions in the same session.
DERMATOLOGIC SURGERY
(2022)
Article
Hematology
Tennille N. Webb, Jeremiah Bell, Russell Griffin, Lynn Dill, Catherine Gurosky, David Askenazi
Summary: This study compared the complications of centrifuge TPE (cTPE) and membrane TPE (mTPE) in pediatric patients. The results showed that mTPE with heparin anticoagulation was well-tolerated in younger children and had similar complication rates compared to cTPE with citrate anticoagulation in older children.
JOURNAL OF CLINICAL APHERESIS
(2022)
Article
Obstetrics & Gynecology
Abby M. Basalely, Russell Griffin, Katja M. Gist, Ronnie Guillet, David J. Askenazi, Jennifer R. Charlton, David T. Selewski, Mamta Fuloria, Frederick J. Kaskel, Kimberly J. Reidy
Summary: The study showed that dysnatremia in the first postnatal week was associated with an increased risk of mortality, particularly hypernatremia and combined hypo/hypernatremia in neonates without AKI. This may indicate the importance of fluid management in influencing neonatal mortality outcomes, regardless of AKI status.
JOURNAL OF PERINATOLOGY
(2022)
Article
Critical Care Medicine
Peter J. Abraham, Irina Gonzalez-Sigler, Lindy Reynolds, Russell L. Griffin, Rondi B. Gelbard, Jeffrey D. Kerby, John B. Holcomb, Jan O. Jansen
Summary: This study conducted a secondary analysis on the Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial and found that faster time-to-randomization was associated with increased mortality. Only a small percentage of patients were enrolled within the shortest time window, indicating a need to shorten the time to randomization in future trials to balance enrollment and mortality.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Otorhinolaryngology
Amrita Mukherjee, Howard W. Wiener, Russell L. Griffin, Carrie Lenneman, Arka Chatterjee, Lisle M. Nabell, Cora E. Lewis, Sadeep Shrestha
Summary: This study assessed the disparities in distribution of cardiovascular disease (CVD) risk factors in patients with head and neck squamous cell carcinoma (HNSCC). The results showed that there were demographic differences in the prevalence and incidence of CVD risk factors. Diabetes was more prevalent in black patients, and rural patients had a higher risk of developing diabetes within one year.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Correction
Pediatrics
Arwa Nada, David Askenazi, Juan C. Kupferman, Maroun Mhanna, John D. Mahan, Louis Boohaker, Linzi Li, Russell L. Griffin
PEDIATRIC NEPHROLOGY
(2022)
Article
Public, Environmental & Occupational Health
David C. Schwebel, Margaret F. Canter, Ragib Hasan, Russell Griffin, Taylor R. White, Anna Johnston
Summary: This study used observational methods to examine distracted pedestrian behavior in different urban areas and found that distraction rates and circumstances vary depending on the setting. These results offer valuable data to inform intervention programs that target specific populations in appropriate locations.
TRAFFIC INJURY PREVENTION
(2022)
Article
Obstetrics & Gynecology
Jennifer Chmielewski, Paulomi M. Chaudhry, Matthew W. Harer, Shina Menon, Andrew M. South, Ashley Chappell, Russell Griffin, David Askenazi, Jennifer Jetton, Michelle C. Starr
Summary: The objective of this study was to investigate whether neonatal acute kidney injury (AKI) was documented in NICU discharge summaries and estimate if nephrology consultation mediated this association. The results showed a low prevalence of AKI documentation at NICU discharge. AKI severity and serum creatinine (SCr)-only AKI increased the odds of AKI documentation. Nephrology consultation mediated the associations of AKI severity and diagnostic criteria with documentation.
JOURNAL OF PERINATOLOGY
(2022)
Article
Hematology
Rondi B. Gelbard, Russell L. Griffin, Lindy Reynolds, Peter Abraham, Jeffrey Warner, Parker Hu, Jeffrey D. Kerby, Rindi Uhlich, Marisa B. Marques, Jan O. Jansen, John B. Holcomb
Summary: This study evaluated the outcomes of early, small volume red blood cell transfusion in patients with presumed hemorrhagic shock. The results showed that transfusion of 1-3 units of blood in patients meeting clinical triggers for massive transfusion was not associated with worse outcomes.
Article
Public, Environmental & Occupational Health
Adeniyi J. Idigo, J. Michael Wells, Matthew L. Brown, Howard W. Wiener, Russell L. Griffin, Gary Cutter, Sadeep Shrestha, Rachael A. Lee
Summary: This study aimed to evaluate the regional epidemiology of MDR Pseudomonas CAP and its association with COPD. The results showed that the incidence of MDR Pseudomonas CAP remained stable over time, while COPD was associated with Pseudomonas CAP but not with MDR Pseudomonas CAP.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Clinical Neurology
Thomas G. Brott, James F. Meschia, Brajesh K. Lal, Angel Chamorro, Virginia J. Howard, George Howard
Summary: The SPACE-2 trial compared three treatments for preventing stroke in patients with asymptomatic carotid stenosis. The findings were inconclusive due to low enrollment. The CREST-2 trial is expected to provide much-needed evidence for guiding treatment in asymptomatic patients.
Article
Peripheral Vascular Disease
Oluwasegun P. P. Akinyelure, Byron C. C. Jaeger, Suzanne Oparil, April P. P. Carson, Monika M. M. Safford, George Howard, Paul Muntner, Shakia T. T. Hardy
Summary: This study analyzed data to determine the impact of social determinants of health on the higher proportion of Black adults with uncontrolled blood pressure. Factors such as low education, low income, living in a health professional shortage area, disadvantaged neighborhood, and high-poverty zip code contribute to this disparity.
Article
Cardiac & Cardiovascular Systems
Russell P. Sawyer, Bradford B. Worrall, Virginia J. Howard, Michael G. Crowe, George Howard, Hyacinth I. Hyacinth
Summary: This study aims to examine the racial disparity in the prevalence and trajectory of vascular cognitive impairment and dementia in non-Hispanic White and non-Hispanic Black participants. It will focus on the role of cerebral small vessel disease and genetic risk factors for Alzheimer's disease and related dementias.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)