Article
Neurosciences
Jing Wang, Yujiao Lu, Christopher Carr, Krishnan M. Dhandapani, Darrell W. Brann
Summary: This study found that long-term (months) after traumatic brain injury (TBI), there is a significant presence of proinflammatory senescent cells in the brain. The administration of senolytic drugs can improve long-term functional outcomes by reducing inflammation and neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Rehabilitation
Marie-Julie Potvin, Pauline Brayet, Veronique Paradis, Charles Overbeek, Erik Therrien, Laurie-Anne Dion, Francis Bernard, Nadia Gosselin, Isabelle Rouleau, Olivier Boucher, Jean-Francois Giguere
Summary: The study aimed to predict long-term functional outcomes in traumatic brain injury patients using the new test EXACT and found that EXACT, in some cases, may predict functional outcomes more accurately than PTA, suggesting it could be a promising tool for future TBI recovery research.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Clinical Neurology
Cassidy Q. B. Mostert, Ranjit D. Singh, Maxime Gerritsen, Erwin J. O. Kompanje, Gerard M. Ribbers, Wilco C. Peul, Jeroen T. J. M. van Dijck
Summary: This systematic review investigated the long-term outcome after severe traumatic brain injury (sTBI) and found limited and heterogeneous literature in this area. Mortality and unfavorable outcome rates were high, but a considerable proportion of survivors achieved favorable outcomes.
ACTA NEUROCHIRURGICA
(2022)
Article
Critical Care Medicine
Markus B. Skrifvars, Nora Luethi, Michael Bailey, Craig French, Alistair Nichol, Tony Trapani, Colin McArthur, Yaseen M. Arabi, Stepani Bendel, David J. Cooper, Rinaldo Bellomo, EPO TBI Investigators, ANZICS Clinical Trials Grp
Summary: Recombinant erythropoietin (EPO) did not decrease overall long-term mortality nor improve functional outcome in moderate or severe traumatic brain injury (TBI) patients treated in the intensive care unit (ICU). The limited sample size makes it difficult to draw final conclusions about the use of EPO in TBI.
INTENSIVE CARE MEDICINE
(2023)
Article
Surgery
Dina M. Filiberto, Brian F. Jimenez, Emily K. Lenart, Dih Dih Huang, Marion E. Hare, Elizabeth A. Tolley, Louis J. Magnotti
Summary: Traumatic spine fractures have long-term effects on patients' functional outcomes. Age, thoracic fractures, lower extremity fractures, discharge location, and time to operative fixation are associated with poor functional outcomes.
Article
Critical Care Medicine
Brandon Bonds, Amit Dhanda, Christine Wade, Carla Diaz, Jennifer Massetti, Deborah M. Stein
Summary: Accurate prediction of outcomes following TBI is crucial for intervention and decision-making. Clinical providers showed accurate prediction of survival but struggled with predicting poor functional outcomes. Prognostic models like CRASH and IMPACT, when combined with clinical judgment, can improve accuracy in predicting functional outcomes.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
Article
Pharmacology & Pharmacy
Cindy Santiago-Castaneda, Saul Huerta de la Cruz, Christopher Martinez-Aguirre, Sandra Adela Orozco-Suarez, Luisa Rocha
Summary: This study demonstrates that orally administered cannabidiol (CBD) can reduce the excessive release of glutamate caused by traumatic brain injury (TBI) and facilitate functional recovery. CBD pretreatment significantly reduces glutamate concentration and improves survival rate and body weight gain. Long-term treatment also shows a reduction in glutamate concentration and improvement in sensorimotor function.
Article
Rehabilitation
Clara Debarle, Vincent Perlbarg, Alice Jacquens, Melanie Pelegrini-Issac, Marion Bisch, Amelie Prigent, Blandine Lesimple, Elsa Caron, Muriel Lefort, Eleonore Bayen, Damien Galanaud, Pascale Pradat-Diehl, Louis Puybasset, Vincent Degos
Summary: This study evaluated global volumetric and diffusion parameters related to long-term outcome after TBI, and found that global mean diffusivity is a more promising radiomarker for discriminating good outcome long term after TBI. Further research is needed to understand the evolution of these long-term radiological parameters.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Immunology
Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong, Yanqin Gao
Summary: The study demonstrates that cordycepin can protect neurological function by suppressing neutrophil infiltration, preserving blood-brain barrier integrity, and altering microglia/macrophage polarization after traumatic brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Natascha Ekdahl, Alison K. Godbolt, Catharina Nygren Deboussard, Marianne Lannsjo, Britt-Marie Stalnacke, Maud Stenberg, Trandur Ulfarsson, Marika C. Moller
Summary: The study investigates the relationship between early global cognitive functioning and cognitive flexibility in severe traumatic brain injury patients. The results show a significant correlation between early global cognitive functioning, cognitive flexibility, and long-term outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Marta Celorrio, Kirill Shumilov, Camryn Payne, Sangeetha Vadivelu, Stuart H. Friess
Summary: This study examined the neuroprotective effects of administering minocycline, an inhibitor of microglial activation, at a clinically feasible time point in a model of TBI plus delayed hypoxemia. Short-course minocycline treatment reduced acute neuronal damage and showed long-term improvements in neurodegeneration, synapse loss, and cognitive performance. Timing and duration of minocycline treatment may play a crucial role in neuroprotection following TBI.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medical Laboratory Technology
Yun Xie, Zhidong Guo, Fanghui Chen, Chen Xiao, Jianping Xu, Dezhi Bo
Summary: The study found that serum netrin-1 concentrations in TBI patients are closely related to prognosis, and may serve as a potential biomarker for predicting outcomes in TBI patients.
CLINICA CHIMICA ACTA
(2021)
Article
Critical Care Medicine
Stephen Gyung Won Lee, Young Sun Ro, Eujene Jung, Sung Bae Moon, Gwan Jin Park, Hanna Yoon, Jeong Ho Park, Sang Do Shin
Summary: This study evaluates the association between serum acylcarnitine levels and functional outcomes at 1 month/6 months after traumatic brain injury. The study finds that higher serum acylcarnitine levels are associated with poor functional outcomes for TBI patients with intracranial injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Sharon B. Shively, Sarah L. Edgerton, Diego Iacono, Dushyant P. Purohit, Bao-Xi Qu, Vahram Haroutunian, Kenneth L. Davis, Ramon Diaz-Arrastia, Daniel P. Perl
ACTA NEUROPATHOLOGICA
(2017)
Article
Neurosciences
Leah Harburg, Erin McCormack, Kimbra Kenney, Carol Moore, Kelly Yang, Pieter Vos, Bram Jacobs, Christopher J. Madden, Ramon Diaz-Arrastia, Tanya Bogoslovsky
Article
Clinical Neurology
Allison R. Kaup, Carrie Peltz, Kimbra Kenney, Joel H. Kramer, Ramon Diaz-Arrastia, Kristine Yaffe
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2017)
Article
Genetics & Heredity
John K. Yue, Ethan A. Winkler, Jonathan W. Rick, John F. Burke, Thomas W. McAllister, Sam S. Oh, Esteban G. Burchard, Donglei Hu, Jonathan Rosand, Nancy R. Temkin, Frederick K. Korley, Marco D. Sorani, Adam R. Ferguson, Hester F. Lingsma, Sourabh Sharma, Caitlin K. Robinson, Esther L. Yuh, Phiroz E. Tarapore, Kevin K. W. Wang, Ava M. Puccio, Pratik Mukherjee, Ramon Diaz-Arrastia, Wayne A. Gordon, Alex B. Valadka, David O. Okonkwo, Geoffrey T. Manley
Article
Critical Care Medicine
Kyle B. Womack, Christopher Paliotta, Jeremy F. Strain, Johnson S. Ho, Yosef Skolnick, William W. Lytton, L. Christine Turtzo, Roderick McColl, Ramon Diaz-Arrastia, Peter J. Bergold
JOURNAL OF NEUROTRAUMA
(2017)
Article
Critical Care Medicine
Frederick K. Korley, Ramon Diaz-Arrastia, Hayley J. Falk, Matthew E. Peters, Jeannie-Marie S. Leoutsakos, Durga Roy, Vani Rao, Haris Iqbal Sair, Uju Ofoche, Anna J. Hall, Freshta Akbari, Timothy E. Van Meter, Allen D. Everett, Jennifer E. Van Eyk, Kathleen T. Bechtold
JOURNAL OF NEUROTRAUMA
(2017)
Article
Critical Care Medicine
Arthur Stacey, Sylvia Lucas, Sureyya Dikmen, Nancy Temkin, Kathleen R. Bell, Allen Brown, Robert Brunner, Ramon Diaz-Arrastia, Thomas K. Watanabe, Alan Weintraub, Jeanne M. Hoffman
JOURNAL OF NEUROTRAUMA
(2017)
Article
Critical Care Medicine
Tanya Bogoslovsky, David Wilson, Yao Chen, David Hanlon, Jessica Gill, Andreas Jeromin, Linan Song, Carol Moore, Yunhua Gong, Kimbra Kenney, Ramon Diaz-Arrastia
JOURNAL OF NEUROTRAUMA
(2017)
Article
Multidisciplinary Sciences
Jessica L. Nielson, Shelly R. Cooper, John K. Yue, Marco D. Sorani, Tomoo Inoue, Esther L. Yuh, Pratik Mukherjee, Tanya C. Petrossian, Jesse Paquette, Pek Y. Lum, Gunnar E. Carlsson, Mary J. Vassar, Hester F. Lingsma, Wayne A. Gordon, Alex B. Valadka, David O. Okonkwo, Geoffrey T. Manley, Adam R. Ferguson
Editorial Material
Critical Care Medicine
James J. Gugger, Ramon Diaz-Arrastia
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Article
Medical Laboratory Technology
Jennifer G. Cooper, Sophie Stukas, Mohammad Ghodsi, Nyra Ahmed, Ramon Diaz-Arrastia, Daniel T. Holmes, Cheryl L. Wellington
Summary: This study aimed to establish reference intervals (RI) for plasma protein biomarkers relevant to neurological diseases and disorders using a large Canadian population-based cohort. The study generated discrete and continuous RIs for each biomarker at different age partitions. These RIs can refine normative cut-offs and improve the precision of interpreting biomarker levels.
CLINICAL BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neuroimaging
Pratusha Reddy, Kurtulus Izzetoglu, Patricia A. Shewokis, Michael Sangobowale, Ramon Diaz-Arrastia
Summary: The damage to the cerebrovascular network is a common feature of traumatic brain injury (TBI). This study found significant differences in the time-frequency characteristics of fNIRS signal components between healthy controls and TBI patients, and these differences changed across phases of the injury.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Baoxi Qu, Yunhua Gong, Jassica M. Gill, Kimbra Kenney, Ramon Diaz-Arrastia
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)