Article
Immunology
Simeon D. Kimmel, June-Ho Kim, Bindu Kalesan, Jeffrey H. Samet, Alexander Y. Walley, Marc R. Larochelle
Summary: The study reveals that AMA discharges are more common among patients with Injection drug use-associated infective endocarditis (IDU-IE) and the trend is increasing annually, indicating the need for targeted interventions to reduce such occurrences.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Marcus Wing Choy Loe, Kee Thai Yeo
Summary: This study aimed to describe the patterns of early-life surface colonization with multidrug resistant organisms (MDROs) among newborns in the neonatal intensive care unit (NICU). The study found that MDROs accounted for a certain proportion of gram-negative bacteria in this setting.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Saira Butt, Mitchell McClean, Jane Turner, Sarah Roth, Angela L. Rollins
Summary: This study aimed to understand the challenges and resources in providing care to patients with injection drug use associated infective endocarditis (IDU-IE). The results showed that patient-level barriers included pain control, difficult patient interactions, and social determinants of health. Provider-level barriers included inequity, expectations for recovery, varying levels of hope, communication style, and prescribing medication for SUD. System-level barriers included repeat surgery, placement, and resources for SUD and mental health.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Immunology
Joshua A. Barocas, Golnaz Eftekhari Yazdi, Alexandra Savinkina, Shayla Nolen, Caroline Savitzky, Jeffrey H. Samet, Honora Englander, Benjamin P. Linas
Summary: This study aimed to estimate the population-level mortality rate of infective endocarditis (IE) among people who inject opioids. High-frequency users with higher infection risk techniques were found to have significantly higher probabilities of death from IE. It was estimated that approximately 257,800 people are expected to die from IE by 2030. Implementing harm reduction strategies, including expanding syringe service programs, could have a major impact on decreasing the mortality rate associated with the opioid epidemic.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Guillaume Morel, Guillaume Mulier, Etienne Ghrenassia, Moustafa Abdel Nabey, Yacine Tandjaoui, Achille Kouatchet, Laura Platon, Frederic Pene, Anne-Sophie Moreau, Amelie Seguin, Damien Contou, Romain Sonneville, David Rousset, Muriel Picard, Guillaume Dumas, Djamel Mokart, Bruno Megarbane, Guillaume Voiriot, Isabelle Oddou, Elie Azoulay, Lucie Biard, Lara Zafrani
Summary: Clostridioides bacteremia typically occurs in ICU patients with underlying conditions, characterized by septic shock and digestive symptoms. Despite high sensitivity to common antimicrobial drugs, mortality rates remain high, especially with the presence of hemolysis posing a greater risk of death.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans, Janesh Pillay
Summary: This study evaluated the diagnostic yield of FDG-PET/CT in intensive care patients with BSI, showing a high sensitivity and specificity for identifying infection foci. Poor image quality was significantly associated with decreased likelihood of finding infection foci.
Article
Infectious Diseases
Kazuyoshi Gotoh, I. Putu Bayu Mayura, Hideharu Hagiya, Kyoichi Obata, Tatsuo Ogawa, Koji Iio, Takumi Fujimori, Fumio Otsuka, Osamu Matsushita
Summary: Tsukamurella, an environmentally organism, may cause various infections in humans. Molecular-based approach is indispensable for correct identification of this fastidious pathogen, as demonstrated in a case of Tsukamurella inchonensis bacteremia with septic pulmonary emboli. Molecular diagnosis was crucial for successful treatment and further understanding of characteristics and appropriate treatment regimens for this type of pathogens.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Jose A. Rodriguez, Alexis C. Gushiken
Summary: This article reports a case of Roseomonas infection in a man in his 60s who presented with symptoms of aphasia, right-sided paresthesia, and new onset seizures. The patient was treated with antibiotics and discharged in stable condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Infectious Diseases
Gregory J. Sinner, Rahul Annabathula, Karolina Viquez, Talal S. Alnabelsi, Steve W. Leung
Summary: This study highlights contemporary outcomes in endocarditis during pregnancy, reflecting on historical case reports in the context of the opioid epidemic. More Staphylococcus infections, more right-sided valvular involvement, more conservative management, and improved maternal and fetal mortality were observed compared to previous reviews.
INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Abtin Jafroodifar, Ryan Thibodeau, Ernest Scalzetti
Summary: Illicit drugs, especially intravenous ones, are becoming more common worldwide. Reusing or sharing needles among intravenous drug users can lead to life-threatening infections. We present a case of a patient who injected drugs into her internal jugular vein, resulting in severe fungal infective endocarditis and bilateral septic pulmonary emboli. Imaging findings revealed vegetations on the tricuspid and mitral valves, cavitary lung lesions, and broken needles. Radiologists should be aware of the possibility of broken needles in patients with a history of intravenous drug use to improve source control and outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Microbiology
Jack Mchugh, Omar Abu Saleh
Summary: Blood culture-negative infective endocarditis (BCNE) is a serious condition with high morbidity and mortality. This review discusses the epidemiology, microbiology, diagnosis, and treatment of BCNE, taking into account advancements in molecular diagnostics and increased access to cardiac surgery. Diagnostic approaches include patient history, blood and serum testing, serological testing, and molecular techniques, while treatment depends on the likely causative agent and the presence of prosthetic material.
Article
Obstetrics & Gynecology
Henry P. Foote, Daniel K. Benjamin, Rachel G. Greenberg, Reese H. Clark, Christoph P. Hornik
Summary: This multicenter cohort study investigated outcomes for infants in the neonatal intensive care unit with septic shock. Mortality rate was 50%, and dopamine was the most commonly used vasopressor. Hydrocortisone was administered in combination with a vasopressor in 38% of cases. Infants treated with epinephrine alone had significantly higher odds of mortality, while adjuvant hydrocortisone was associated with decreased mortality.
JOURNAL OF PERINATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Grapsa, Christopher Blauth, Y. S. Chandrashekhar, Bernard Prendergast, Blair Erb, Michael Mack, Valentin Fuster
Summary: This paper presents a clinical case of Staphylococcus aureus infective endocarditis in a 19-year-old female patient and discusses the current evidence on the management and treatment of the disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Microbiology
Carmela Del Giudice, Emanuele Vaia, Daniela Liccardo, Federica Marzano, Alessandra Valletta, Gianrico Spagnuolo, Nicola Ferrara, Carlo Rengo, Alessandro Cannavo, Giuseppe Rengo
Summary: Infective endocarditis is an inflammatory disease caused by bacteria, and prevention and improvement of oral hygiene are important strategies. The oral microbiota may be one of the significant risk factors for infection.
Article
Infectious Diseases
Anna Damlin, Katarina Westling
Summary: This study revealed that patients with IDU-IE were younger, less frequently treated with surgery, and had a higher incidence of vascular phenomena and history of previous IE, which are important for improving the management of this population.
BMC INFECTIOUS DISEASES
(2021)
Meeting Abstract
Allergy
C. Cheah, K. Dass, A. Guthrie, B. Dalal
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2018)
Meeting Abstract
Critical Care Medicine
Darshan Sarode, Bhavinkumar Dalal, Shaiva Ginoya, Marie Tominna
Meeting Abstract
Critical Care Medicine
Ahmad Said, Bhavinkumar Dalal
Editorial Material
Medicine, General & Internal
Christopher M. Williams, Richard L. Alweis, Alec B. O'Connor, Bhavin Dalal, Devesh Rai, Abdullah Abdullah, Richard Kopelman, Patricia Cornett, Michael O. Frank, Vera P. Luther, Elaine A. Muchmore
AMERICAN JOURNAL OF MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
C. Shams, B. D. Dalal, R. Mehndiratta, G. Leamon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
F. Figueroa Rodriguez, S. Savedchuk, M. Schloop, B. D. Dalal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
M. Sczepanski, B. D. Dalal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
H. Iftikhar, C. Zhang, G. Grasso-Knight, B. D. Dalal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
V. Jayaschandran, M. Kwon, H. Iftikhar, A. Michel, B. D. Dalal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Medicine, General & Internal
A. B. O'Connor, C. M. Williams, B. Dalal, M. S. Sulistio, T. K. Roth, C. K. Milne, F. A. Collichio, E. A. Muchmore, R. Alweis
JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES
(2018)
Letter
Respiratory System
Eva Otoupalova, Bhavinkumar Dalal, Vishal Patel
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2018)
Article
Respiratory System
Vivek Jayaschandran, Amy N. Mertens, Vishal K. Patel, Bhavinkumar Dalal
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2018)
Meeting Abstract
Critical Care Medicine
Vivek Jayaschandran, Emily Schuiteman, Eva Otoupalova, Shaiva Meka, Judith Boura, Paul Christensen, Bhavinkumar Dalal
Meeting Abstract
Critical Care Medicine
Cheryl Cheah, Kathleen Dass, Ashley Guthrie, Bhavinkumar Dalal
Article
Respiratory System
Emily Schuiteman, Thomas Verrill, Nader Mina, Bhavinkumar Dalal
RESPIRATORY MEDICINE CASE REPORTS
(2017)
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)