Article
Surgery
Monica Manrique, Esperanza Mantilla-Rivas, Antonio R. Porras Perez, Justin R. Bryant, Md Sohel Rana, Liyun Tu, Robert F. Keating, Albert K. Oh, Marius G. Linguraru, Gary F. Rogers
Summary: This study found that 3.3% of normocephalic children aged 1 to 5 years have incidentally identified, premature cranial suture fusion, with normal cranial index and grossly normal head shape. Routine screening of affected patients is emphasized as the clinical significance of this result remains unclear.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Jacob Dinis, Alexandra Junn, Xiaona Lu, Joseph Lopez, John Persing
Summary: Combined sagittal and metopic craniosynostosis is a rare condition that can result in a wide range of cranial morphologies. This case highlights the delayed diagnosis possibly due to structural changes associated with concurrent metopic suture synostosis. It emphasizes the importance of noninvasive imaging in the diagnosis of craniosynostosis and the limitations of relying on classic diagnostic patterns.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Anatomy & Morphology
Silviya Nikolova, Diana Toneva, Gennady Agre, Nikolai Lazarov
Summary: The study found significant differences in sagittal suture closure between crania with persistent metopic suture and normal closure, with the former showing lower closure. The linear regression models for age-at-death prediction in metopic crania had almost twice the error compared to the control group.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Clinical Neurology
Matthias Schulz, Linda Liebe-Puschel, Karl Seelbach, Laura Paulikat, Felix Fehlhaber, Karin Schwarz, Christoph Blecher, Ulrich-Wilhelm Thomale
Summary: Surgical correction for sagittal and metopic craniosynostosis aims to alter abnormal cranial shape towards normal controls. The study compared craniometric parameters of control groups to those after endoscopic and conventional correction, with results showing that both techniques successfully altered head shape towards normal controls, with endoscopic technique appearing closer to normal controls in SCS and conventional technique in MCS.
NEUROSURGICAL FOCUS
(2021)
Article
Surgery
Thais Miguel Monte, Rafael Denadai, Cesar Augusto Raposo-Amaral, Enrico Ghizoni, Cassio Eduardo Raposo-Amaral
Summary: Limited research on long-term craniofacial changes and quality of life outcomes after pi-plasty procedures led to this study, which found significant increases in facial angles over 5 years. Patients reported high satisfaction with their appearance, positively impacting their quality of life.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Clinical Neurology
Nathan K. Leclair, William A. Lambert, Joshua Knopf, Petronella Stoltz, David S. Hersh, Jonathan E. Martin, Markus J. Bookland
Summary: This study compared the postoperative skull morphology changes in patients with sagittal craniosynostosis and metopic craniosynostosis. The results showed that patients with metopic craniosynostosis had a prolonged rate of change compared to patients with sagittal craniosynostosis, indicating that metopic craniosynostosis patients may require longer treatment and follow-up.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Article
Genetics & Heredity
Cristina M. Justice, Anthony M. Musolf, Araceli Cuellar, Wanda Lattanzi, Emil Simeonov, Radka Kaneva, Justin Paschall, Michael Cunningham, Andrew O. M. Wilkie, Alexander F. Wilson, Paul A. Romitti, Simeon A. Boyadjiev
Summary: Craniosynostosis is a congenital defect characterized by premature fusion of one or more skull sutures. Genome-wide association studies have identified genes and variants associated with this defect, and further sequencing and functional studies of these regions are important for understanding the underlying mechanisms.
Article
Clinical Neurology
Cordell M. Baker, Vijay M. Ravindra, Barbu Gociman, Faizi A. Siddiqi, Jesse A. Goldstein, Matthew D. Smyth, Amy Lee, Richard C. E. Anderson, Kamlesh B. Patel, Craig Birgfeld, Ian F. Pollack, Thomas Imahiyerobo, John R. W. Kestle
Summary: The study reported early treatment experience of patients with isolated sagittal synostosis in a collaborative network. Different surgical methods resulted in similar satisfactory postoperative cephalic indices, while the use of tranexamic acid may reduce the need for transfusion in cases of cranial vault remodeling.
NEUROSURGICAL FOCUS
(2021)
Article
Clinical Neurology
Alexander T. Wilson, Linda Gaillard, Sarah L. Versnel, Jochem K. H. Spoor, Marie-Lise C. Van Veelen, Irene M. J. Mathijssen
Summary: The study reports that spring-assisted cranial vault expansion (SAE) may result in less favorable outcomes in patients with Crouzon syndrome and sagittal suture synostosis compared to frontobiparietal (FBP) expansion, potentially due to issues such as concurrent intracranial hypertension and poor aesthetic results. Patients with Crouzon syndrome and sagittal synostosis who undergo SAE often require a revision FBP operation, leading the authors to consider Crouzon syndrome a contraindication for correcting SS with springs.
NEUROSURGICAL FOCUS
(2021)
Article
Dentistry, Oral Surgery & Medicine
L. Chandler, K. E. Park, O. Allam, M. A. Mozaffari, S. Khetpal, J. Smetona, N. Pourtaheri, X. Lu, J. A. Persing, M. Alperovich
Summary: This study conducted a craniomorphometric analysis of patients undergoing surgery for metopic synostosis, finding that the frontal angle and aEBF were the most accurate measures of severity in this condition.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Cell Biology
Connor Cross, Roman H. Khonsari, Leila Galiay, Giovanna Patermoster, David Johnson, Yiannis Ventikos, Mehran Moazen
Summary: This study conducted sensitivity tests to understand the impact of various input parameters on predicting post-operative skull morphology in sagittal synostosis patients. Results showed that the choice of elastic modulus for craniotomies had the greatest influence on skull morphology, while bone formation modeling method across sutures/craniotomies had a considerable impact on brain pressure. The study lays the foundation for future comparative studies using FE method to compare outcomes of different reconstruction techniques for craniosynostosis management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Perry S. Bradford, Mariam Ishaque, Ellen Shaffrey, Christine Schaeffer, John A. Jane, Hasan Syed, Jonathan Black
Summary: The study reviewed the evolution of surgical techniques for correcting sagittal synostosis and compared patient outcomes. The FLAG and endoscopic groups had the best results in terms of surgical time, transfusion volume, and hospital stay, while there were no significant differences in cranial index or revision procedures among the four surgical correction methods.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Editorial Material
Surgery
Seija Maniskas, Ludmila Chandler, Karl Bruckman, Navid Pourtaheri, Michael DiLuna, Derek M. Steinbacher
Summary: Metopic craniosynostosis leads to trigonocephaly, with distinct features including a triangular forehead with metopic ridge, bitemporal pinching, and narrow-set eyes with recessed lateral orbital rims. Surgical management, which may involve open expansion and vault remodeling, is controversial but aims to improve neurocognitive and aesthetic outcomes. This article and video illustrate the diagnosis and treatment of metopic craniosynostosis, showcasing the senior author's open approach, three-dimensional virtual surgical planning, and technical steps.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Lu, A. J. Forte, M. Alperovich, N. Alonso, J. A. Persing
Summary: This study compared the orbital and peri-orbital morphological variations in Apert syndrome patients with different cranial vault suture synostosis, and found that the different types of synostosis have varying effects on orbital volume and globe protrusion.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Surgery
Aditi Kanth, Kanlaya Ditthakasem, Morley Herbert, Jeffrey A. Fearon
Summary: This retrospective study reviewed the medical records of all patients undergoing primary and secondary remodeling corrections between 2010 and 2020. It found that a higher proportion of primary procedures received allogeneic blood compared to secondary corrections. The length of hospital stay and surgical infection rate were similar between the two groups. The age at primary correction and strip craniectomies may be associated with a higher likelihood of subsequent secondary correction.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)