Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Shaolong Zhou, Lingling Wan, Xu Liu, Delin Hu, Feng Lu, Xihang Chen, Fangguo Liang
Summary: Diabetes delays wound healing and impairs function of Schwann cells (SCs) in the peripheral nervous system. SCs in diabetic mice are dysfunctional and fail to rapidly activate a repair program after skin wound injury. Additionally, high glucose conditions impair SC function and affect the paracrine effects of SCs on myofibroblast formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Xiao Feng, Wei Feng, Yu Ji, Tingting Jin, Jingyu Li, Jincai Guo
Summary: This study investigates the relationship between TGF-beta 1 and SOCS7 in the re-epithelialization of keratinocytes during skin wound healing. The results show that TGF-beta 1 downregulates SOCS7 expression and overexpression of SOCS7 suppresses TGF-beta 1-induced keratinocyte migration. TGF-beta 1 negatively regulates SOCS7 through the binding of EGR1 to the SOCS7 promoter. This study identifies the TGF-beta 1/EGR1/SOCS7 pathway as a potential therapeutic target for promoting wound healing.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Nanoscience & Nanotechnology
Abdulrahman E. Koshak, Mardi M. Algandaby, Mohammad Mujallid, Ashraf B. Abdel-Naim, Nabil A. Alhakamy, Usama A. Fahmy, Anas Alfarsi, Shaimaa M. Badr-Eldin, Thikryat Neamatallah, Mohammed Z. Nasrullah, Hossam M. Abdallah, Ahmed Esmat
Summary: OFI and OFI-SNEDDS demonstrated superior wound healing activity in a rat model of full-thickness skin excision, with enhanced antioxidant and anti-inflammatory properties. OFI-SNEDDS showed higher activity compared to OFI seed oil, improving collagen and angiogenesis expression.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Basma G. Eid, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Shadab Md, Ashraf B. Abdel-Naim, Giuseppe Caruso, Filippo Caraci
Summary: The study aimed to evaluate the synergistic effect of melittin and diclofenac in a nano-complex, which showed significantly better wound healing activity compared to individual drugs. The nano-complex promoted regenerated epithelium and granulation tissue formation, as well as exhibited enhanced antioxidant activity.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Dharshan Sivaraj, Chikage Noishiki, Nina Kosaric, Harriet Kiwanuka, Hudson C. Kussie, Dominic Henn, Katharina S. Fischer, Artem A. Trotsyuk, Autumn H. Greco, Britta A. Kuehlmann, Filiberto Quintero, Melissa C. Leeolou, Maia B. Granoski, Andrew C. Hostler, William W. Hahn, Michael Januszyk, Ferid Murad, Kellen Chen, Geoffrey C. Gurtner
Summary: According to the American Diabetes Association, there is a significant unmet need for new therapies to accelerate the closure of non-healing wounds. In this study, the effects of NO-releasing gel on diabetic wound healing in mice were investigated. The results showed that topical administration of NO-gel significantly accelerated the rate of wound healing and promoted a more regenerative ECM architecture.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tarfah Al-Warhi, Eman Maher Zahran, Samy Selim, Mohammad M. Al-Sanea, Mohammed M. Ghoneim, Sherif A. Maher, Yaser A. Mostafa, Faisal Alsenani, Mahmoud A. Elrehany, Mohammed S. Almuhayawi, Soad K. Al Jaouni, Usama Ramadan Abdelmohsen, Abeer H. Elmaidomy
Summary: This study demonstrates the potential of Vitis vinifera seed extract in promoting wound healing by accelerating wound closure rates, increasing TGF-beta and VEGF levels, and reducing TNF-alpha and IL-1 beta levels. Phytochemical analysis identified multiple compounds, and molecular docking experiments were performed to investigate the mechanisms of action.
Article
Medical Laboratory Technology
Kang I. Ko, Anton Sculean, Dana T. Graves
Summary: Understanding the cellular mechanisms of expedited healing in various oral tissues and how systemic diseases like diabetes impact them is crucial for preventing and treating diabetes-associated oral complications. Diabetes impairs keratinocyte proliferation and migration, increases inflammation, and reduces connective tissue and bone formation in oral wounds.
TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Albert Stachura, Ishani Khanna, Piotr Krysiak, Wiktor Paskal, Pawel Wlodarski
Summary: Type II diabetes mellitus is a common disease associated with diabetic foot ulcers and impaired wound healing. Animal models are crucial in studying this field, and a leptin-deficient murine model has been widely used. This review systematically summarizes data from over 100 studies, discussing the mechanisms underlying wound healing impairment in this model and potential interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
L. Anna Sheba, V Anuradha, M. Syed Ali, N. Yogananth
Summary: This study investigated the wound healing potential of Couroupita guianensis fruit pulp in rats. The results showed that the ointment prepared from the extract of C. guianensis fruit pulp promoted wound contraction, reduced the wound area, shortened the epithelialization period, and increased hydroxyproline content. The study also found that the extract influenced the expression of VEGF and TGF-beta genes, which are associated with wound healing. These findings provide scientific evidence for the traditional use of this plant in wound healing and suggest its potential as a therapeutic strategy.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biology
Agnes N. Mwaura, Muhammad A. Riaz, Jane B. Maoga, Ezekiel Mecha, Charles O. A. Omwandho, Georgios Scheiner-Bobis, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: The presence of ectopic endometrium in the pelvis characterizes endometriosis, and the transforming growth factor-beta (TGF-beta) superfamily, including betaglycan (BG), plays a role in its pathogenesis. Inhibition of BG shedding and TGF-beta signaling may be potential therapeutic approaches for endometriosis. Measurement of BG in serum and endocervical mucus shows promise as a non-invasive diagnostic tool for endometriosis.
Article
Endocrinology & Metabolism
Jian-Jun Liu, Sylvia Liu, Jiexun Wang, Sharon L. T. Pek, Janus Lee, Resham L. Gurung, Keven Ang, Yi Ming Shao, Subramaniam Tavintharan, Wern Ee Tang, Chee Fang Sum, Su Chi Lim
Summary: This study found that urine LRG1 is associated with the risk of progression to ESKD in individuals with type 2 diabetes. Higher urine LRG1 levels are associated with an increased risk of ESKD and are also related to rapid kidney function decline and progression to macroalbuminuria.
Review
Biotechnology & Applied Microbiology
Catalina Ruiz-Canada, Angel Bernabe-Garcia, Sergio Liarte, Monica Rodriguez-Valiente, Francisco Jose Nicolas
Summary: The application of amniotic membrane on chronic wounds has shown effectiveness in resetting wound healing, particularly in re-epithelialization. Amniotic membrane affects wound healing by modulating cell signaling pathways and growth factors. Additionally, it influences protein expression in epithelial cells, promoting the progression of re-epithelialization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhengxing Wang, Yitian Bai, Hongtao Nie, Qiaoyue Xu, Zhihui Yin, Yanming Zhang, Xuwang Yin, Xiwu Yan
Summary: Through transcriptome analysis and morphological observation, this study revealed the molecular mechanisms and process of siphon regeneration in Ruditapes philippinarum, highlighting the important roles of protein biosynthesis and metabolism in wound healing and regeneration. The study also identified the Wnt and TGF-beta signaling pathways as crucial in siphon regeneration.
Article
Ophthalmology
Sabeeh Kamil, Rajiv R. Mohan
Summary: Corneal stromal wound healing is a complex process involving apoptosis, proliferation, migration, and transdifferentiation of keratocytes. The central player guiding stromal responses is TGF-beta signaling, while other major regulators include myofibroblasts, basement membrane, collagen fibrils, and small leucine-rich proteoglycans. Understanding the roles of these regulators has helped develop novel therapies to prevent corneal opacity.
Article
Engineering, Biomedical
Tadahiro Takayama, Jisen Dai, Keita Tachi, Ryutaro Shohara, Hironori Kasai, Kentaro Imamura, Seiichi Yamano
JOURNAL OF BIOMATERIALS APPLICATIONS
(2017)
Article
Anesthesiology
Seiichi Yamano, Chi T. Viet, Dongmin Dang, Jisen Dai, Shigeru Hanatani, Tadahiro Takayama, Hironori Kasai, Kentaro Imamura, Ron Campbell, Yi Ye, John C. Dolan, William Myung Kwon, Stefan D. Schneider, Brian L. Schmidt
Article
Engineering, Biomedical
Kentaro Imamura, Keita Tachi, Tadahiro Takayama, Ryutaro Shohara, Hironori Kasai, Jisen Dai, Seiichi Yamano
JOURNAL OF BIOMATERIALS APPLICATIONS
(2018)
Article
Engineering, Biomedical
Seiichi Yamano, Jisen Dai, Shigeru Hanatani, Ken Haku, Takuto Yamanaka, Mika Ishioka, Tadahiro Takayama, Carlo Yuvienco, Sachin Khapli, Amr M. Moursi, Jin K. Montclare
Article
Engineering, Biomedical
Haresh T. More, Joseph A. Frezzo, Jisen Dai, Seiichi Yamano, Jin K. Montclare
Article
Engineering, Biomedical
Seiichi Yamano, Ken Haku, Takuto Yamanaka, Jisen Dai, Tadahiro Takayama, Ryutaro Shohara, Keita Tachi, Mika Ishioka, Shigeru Hanatani, Sanjay Karunagaran, Keisuke Wada, Amr M. Moursi
Article
Biotechnology & Applied Microbiology
Seiichi Yamano, Jisen Dai, Shigeru Hanatani, Ken Haku, Takuto Yamanaka, Mika Ishioka, Tadahiro Takayama, Amr M. Moursi
BIOTECHNOLOGY LETTERS
(2014)
Article
Endocrinology & Metabolism
Paulo G. Coelho, Tadahiro Takayama, Daniel Yoo, Ryo Jimbo, Sanjay Karunagaran, Nick Tovar, Malvin N. Janal, Seiichi Yamano
Article
Chemistry, Multidisciplinary
Seiichi Yamano, Jisen Dai, Carlo Yuvienco, Sachin Khapli, Amr M. Moursi, Jin K. Montclare
JOURNAL OF CONTROLLED RELEASE
(2011)
Article
Cell Biology
Sundeep G. Keswani, Swathi Balaji, Louis D. Le, Alice Leung, Jignesh K. Parvadia, Jason Frischer, Seiichi Yamano, Norton Taichman, Timothy M. Crombleholme
WOUND REPAIR AND REGENERATION
(2013)
Article
Biotechnology & Applied Microbiology
Hironori Kasai, Kenji Inoue, Kentaro Imamura, Carlo Yuvienco, Jin K. Montclare, Seiichi Yamano
JOURNAL OF NANOBIOTECHNOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Mitsuaki Furuhata, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Motoki Senoo, Manami Ozaki, Seiichi Yamano, Shuichi Sato
Summary: This study investigated the bone healing pattern in rat mandibular bone defects with and without RCM containing FGF-2. Real-time assessment revealed that RCM/FGF-2 effectively promoted bone regeneration within the critical-size mandibular defects in rats, with increased volume, BMD, and closure percentage of the NFB area compared to control and RCM groups. Histological evaluation confirmed the presence of osteoblasts, osteocytes, and blood vessels within the newly formed bone.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Manami Ozaki, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Mayu Nagao, Natsuko Tanabe, Akira Nakajima, Naoto Suzuki, Masao Maeno, Seiichi Yamano, Shuichi Sato
ARCHIVES OF ORAL BIOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Seiichi Yamano, Andrew Kwok-Yui Ma, Rabie M. Shanti, Soo-Woo Kim, Keisuke Wada, Cortino Sukotjo
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2011)