Review
Pharmacology & Pharmacy
Ethan Cisneros, Najia Sherwani, Olivia L. Lanier, Nicholas A. Peppas
Summary: RNA is an important tool for therapeutic purposes, particularly in infectious diseases like HIV/AIDS. Systems must be designed to effectively deliver therapeutics to specific tissues, such as those rich in lymphatic tissue, in order to combat latent infection and achieve a functional cure. Despite many attempts, current therapies for HIV/AIDS have not demonstrated long-term efficacy. RNA interference (RNAi) provides a unique opportunity to suppress viral replication and potentially cure chronic HIV/AIDS. However, the delivery of RNA faces challenges due to its negative charge and susceptibility to degradation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biology
Rebecca C. Schugar, Christy M. Gliniak, Lucas J. Osborn, William Massey, Naseer Sangwan, Anthony Horak, Rakhee Banerjee, Danny Orabi, Robert N. Helsley, Amanda L. Brown, Amy Burrows, Chelsea Finney, Kevin K. Fung, Frederick M. Allen, Daniel Ferguson, Anthony D. Gromovsky, Chase Neumann, Kendall Cook, Amy McMillan, Jennifer A. Buffa, James T. Anderson, Margarete Mehrabian, Maryam Goudarzi, Belinda Willard, Tytus D. Mak, Andrew R. Armstrong, Garth Swanson, Ali Keshavarzian, Jose Carlos Garcia-Garcia, Zeneng Wang, Aldons J. Lusis, Stanley L. Hazen, Jonathan Mark Brown
Summary: This study demonstrates the potential of gut microbe-targeted enzyme inhibitors as anti-obesity therapeutics by improving metabolic disturbances and energy expenditure. It underscores the relationship between microbiome and host metabolism.
Article
Chemistry, Multidisciplinary
Cheng Lv, Jian Ao, Ji Wang, Man Tang, An-An Liu, Dai-Wen Pang
Summary: A host-cell-assisted strategy is proposed to construct folate-engineered nanocarriers with maintained biofunctions, which can be further multi-functionalized for tumor real-time imaging and therapy. This cell-based strategy facilitates the development and widespread application of bio-nanocarriers in targeted cancer therapy and promotes interdisciplinary studies of nanotechnology, chemistry, and virology.
Article
Engineering, Biomedical
Chong Zhang, Fen Zeng, Zhengyang Fan, Zhen He, Liang Tai, Qiang Peng, Yixin Zhang, Zhenhua Chao, Wenning Jiang, Lingyun Jia, Lulu Han
Summary: Inflammatory bowel disease (IBD) is a global public health challenge. Current medical treatments are not fully effective and may cause side effects. Researchers have developed a nanoparticle-based treatment strategy for IBD, which can target inflamed colon tissues and reduce systemic exposure of the drug. The nanoparticles also possess reactive oxygen species (ROS)-scavenging ability, which can alleviate inflammation and improve IBD symptoms.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Kristen M. Tummillo, Karsten R. O. Hazlett
Summary: Bioconjugation allows scientists to combine multiple functional elements into one biological unit, targeting specific sites or cell types to enhance response or activity. This targeted approach is particularly advantageous in cancer treatments, where delivering chemotherapies selectively can limit side effects and improve efficacy. Additionally, conjugation can help in treating bacterial infections more selectively and enhancing vaccine efficacy without compromising safety.
Review
Chemistry, Multidisciplinary
Gan Jiang, Chenxuan Wei, Yaoxing Chen, Yingqi Lyu, Jialin Huang, Hongzhuan Chen, Xiaoling Gao
Summary: This passage discusses the process of macropinocytosis, which allows for the internalization of greater quantities of drugs and is a promising avenue for drug delivery. It also introduces various drug delivery systems that utilize macropinocytosis as the primary internalization mechanism. The potential importance of this field lies in its ability to greatly increase the efficiency and specificity of drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Xin Tong, Sravan Kumar Patel, Jing Li, Dorothy Patton, Elaine Xu, Peter L. Anderson, Urvi Parikh, Yvonne Sweeney, Julie Strizki, Sharon L. Hillier, Lisa C. Rohan
Summary: In this study, a nanoparticle-in-film technology was developed for sustained delivery of MK-2048 against HIV. The engineered film loaded with MK-2048 nanoparticles showed comparable efficacy to free MK-2048 in vitro, had no impact on Lactobacillus, and exhibited increased permeability in cell lines and macaque models. The nanoparticle films sustained drug levels in vaginal fluid for at least 3 weeks. This study highlights the synergy of nanomedicine and polymeric film technology for sustained vaginal drug delivery.
Review
Pharmacology & Pharmacy
Nikta Alvandi, Maryam Rajabnejad, Zeynab Taghvaei, Neda Esfandiari
Summary: This article discusses the potential and applications of using viral-like particles (VLPs) for nanoscale engineering, including drug delivery and disease detection. VLPs have advantages such as small size, high stability, and large-scale production, making them suitable for various medical fields.
JOURNAL OF DRUG TARGETING
(2022)
Article
Polymer Science
Andy Chai, Keagan Schmidt, Gregory Brewster, Lu Shi Peng Xiong, Benjamin Church, Timothy Wahl, Hamed Sadabadi, Subha Kumpaty, Wujie Zhang
Summary: This study aimed to develop a pectin-based microsphere system for encapsulating pulmonary drugs and facilitating their delivery to the deep lungs. Pectin-based hydrogel microspheres were produced using electrospray, and the stability and responsiveness of the microspheres were altered through coatings. The microsphere system exhibited high responsiveness and stability in simulated lung fluid.
Review
Chemistry, Multidisciplinary
Yu Han, Panyue Wen, Junjie Li, Kazunori Kataoka
Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Minghua Shen, Yujiao Wang, Fan Hu, Linwen Lv, Kui Chen, Gengmei Xing
Summary: Thrombosis is the most common underlying pathology of cardiovascular diseases, contributing to high morbidity and mortality. The use of nano-drug delivery systems shows promise in addressing the limitations of current thrombolytic drugs, with various approaches being explored for targeted delivery.
Review
Pharmacology & Pharmacy
Xintian Shao, Caicai Meng, Wenjing Song, Tao Zhang, Qixin Chen
Summary: Organelles play crucial roles in biological functions, and disorders in organelles or their interactions are associated with diseases. Cell imaging has become an essential tool for drug delivery, drug discovery, and pharmacological research. Advanced imaging techniques provide researchers with valuable information on organelle ultrastructure, protein interactions, and gene transcription activities, enabling the design and delivery of precision-targeted drugs. This review focuses on organelle-targeted drugs based on imaging technologies and the development of fluorescent molecules for medicinal purposes, and provides comprehensive analysis of subcellular-level elements of drug development.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Cell Biology
Sepiso K. Masenga, Bislom C. Mweene, Emmanuel Luwaya, Lweendo Muchaili, Makondo Chona, Annet Kirabo
Summary: The development of antiretroviral drugs (ARVs) is a significant achievement in managing HIV infections by suppressing viral activity and extending lifespan. However, the success of HIV in evading the immune system has hindered the discovery of an effective treatment for four decades. Understanding the molecular interaction between HIV and host cells is crucial for developing preventive and curative therapies. This review highlights the inherent mechanisms of HIV, such as targeting CD4(+) lymphocytes, downregulating MHC class I and II, antigenic variation, and minimizing antibody access, which collectively render the immune system ineffective.
Article
Pharmacology & Pharmacy
Supriti Ghosh, Pradyumna Jayaram, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
Summary: Cervical cancer is a prevalent cancer among women worldwide, but it can be preventable. Nanotechnology has provided a solution for targeted drug delivery due to the limitations of conventional chemotherapeutics. This review summarizes various drug delivery approaches and nanocarriers, their advantages, limitations, and potential applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hardev Singh, Divya Sareen, Jiya Mary George, Vineet Bhardwaj, Saehee Rha, Suk Joong Lee, Sheetal Sharma, Amit Sharma, Jong Seung Kim
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)