Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Jiangtao Wu, Xiangbin Du, Dongmei Zhang, Jicheng Cui, Xiaoxia Zhang, Xine Duan, John F. Trant, Yingqi Li
Summary: This study developed a dual-gated folate-functionalized nanodiamond drug delivery system that selectively delivers drugs to cancer cells, reducing side effects. The system has activatable fluorescence and cytotoxicity and releases drugs through high levels of glutathione.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Ahmed Aziz, Yahya Sefidbakht, Shokouh Rezaei, Hasan Kouchakzadeh, Vuk Uskokovic
Summary: This study investigates the physicochemical and biological effects of supplementing albumin nanoparticles to improve cancer treatment. It finds that the supplementation of albumin nanoparticles with doxorubicin can enhance drug release and targeting of cancer cells.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sebastian Quintana-Contardo, Orlando Donoso-Gonzalez, Erika Lang, Ariel R. R. Guerrero, Michael Noyong, Ulrich Simon, Marcelo J. J. Kogan, Nicolas Yutronic, Rodrigo Sierpe
Summary: The antineoplastic drug Dacarbazine was encapsulated in beta-cyclodextrin to improve solubility and stability. When combined with plasmonic gold nanoparticles and polyethylene glycol, it exhibited controlled release and potential for drug delivery.
Review
Pharmacology & Pharmacy
Xue Wei, Ming Yang
Summary: Breast cancer is the most common malignant tumor in women, with drug resistance, metastasis, and immune escape posing significant challenges in its treatment. Nanoparticles that target specific cell and subcellular organelles offer a potential solution for immune evasion, metastasis, and drug resistance. This study provides a detailed summary and critical analysis of the latest subcellular targeted therapies using organic nanoparticles, including chemotherapy, gene therapy, immunotherapy, and combination therapy, and discusses the challenges and opportunities of nanoparticle therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Jihoon Kim, Paul A. Archer, Susan N. Thomas
Summary: Lymph nodes are secondary lymphoid tissues involved in immune cell interaction and related to various diseases. Nanotechnologies hold potential in biomedical applications, particularly in relation to lymph nodes. Consideration of lymph node tissue structure, lymphatic system physiology, and delivery mechanisms is crucial for designing nanocarriers for lymph node delivery.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Werner Tegge, Giulia Guerra, Alexander Hoeltke, Lauritz Schiller, Ulrike Beutling, Kirsten Harmrolfs, Lothar Groebe, Hannah Wullenkord, Chunfa Xu, Herbert Weich, Mark Broenstrup
Summary: A novel conjugation strategy was explored to make potent antibiotics more selective by accumulating the drug and releasing it triggered by infection. Bacterial targeting was achieved using a modified fragment of a human antimicrobial peptide, and the release of the drug was limited to infection-related situations through a linker cleaved by neutrophil elastase. The antibacterial efficacy of the conjugates was successfully demonstrated in co-cultures of human neutrophils and Escherichia coli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Physiology
Gene L. Bidwell
Summary: ELPs are bioengineered proteins with a unique physical property of a thermally triggered inverse phase transition, which can be utilized for drug delivery. ELP-fusion proteins have various applications, such as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots, making them a promising platform for the development of biologics.
Article
Biotechnology & Applied Microbiology
Xiaohong Chen, Jianfeng Zhang, Yan Yu, Haoran Wang, Genshan Ma, Di Wang, Hanzhong Cao, Jianping Yang
Summary: Ultrasound-triggered Lido-PPIX@ER hydrogel offers controlled release of lidocaine for the management of postoperative pain, providing individualized and timed relief.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
P. Tiago Ribeiro, J. Agostinho Moreira, J. Fernando Monterio, S. Marta Laranjeira
Summary: Nanoparticle mediated hyperthermia is a method of increasing cancer treatment efficacy by heating tumors from the inside out. This method utilizes nanoparticles that respond to external stimuli and convert energy into heat, causing damage to tumor cells. Combining hyperthermia with chemotherapy has been shown to be more effective, with the high temperature and drug effects working synergistically and allowing for remote controlled drug release.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann
Summary: Incorporation of photoswitchable-phosphatidylcholine analogs in conventional lipid nanoparticles can generate photoactivatable LNPs, allowing light-induced drug release at specific sites, which shows promising potential for clinical development.
Article
Chemistry, Multidisciplinary
Yuxin Duan, Roxanne Glazier, Alisina Bazrafshan, Yuesong Hu, Sk Aysha Rashid, Brian G. Petrich, Yonggang Ke, Khalid Salaita
Summary: This study presents a mechanically triggered hybridization chain reaction (mechano-HCR) for chemical amplification of mechanical events in cells, enabling direct readout of pN forces and measurement of mechano-IC50 for various drugs. This innovative method may provide a convenient route for drug discovery, personalized medicine, and disease diagnosis based on cell mechanical phenotypes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Taner Babacan, Deniz Dogan, Umit Erdem, Aysegul Ulku Metin
Summary: Chitosan-based nanoparticles were prepared and used for the adsorption of anionic dyes. The results showed that under acidic conditions, the nanoparticles had higher adsorption efficiency and the adsorption process followed a pseudo-second-order kinetic model. Additionally, the study found that there was no competitive effect among dye molecules at the same initial concentration. Furthermore, the use of an alternating magnetic field for dye desorption demonstrated that the magnetic nanoparticles could act as a nanoheater and exhibit superior desorption behavior.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Acoustics
Harshani Iresha, Takaomi Kobayashi
Summary: A ultrasound-triggered nicotine release system was developed using a cellulose hydrogel drug carrier, showing that cellulose concentration had significant impact on nicotine release efficiency; hydrogels prepared with 0.9 wt% cellulose exhibited the best nicotine release performance under ultrasound irradiation.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuchi Liu, Jesse Hamilton, Brendan Eck, Mark Griswold, Nicole Seiberlich
Summary: This study developed an approach for simultaneous water-fat separation and myocardial T(1) and T(2) quantification based on cardiac MR fingerprinting. The technique was validated in phantom studies and applied to healthy subjects, showing promising results for visualization of heart anatomy and potential value in diagnosing cardiac diseases.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sara Dastmalchian, Ozden Kilinc, Louisa Onyewadume, Charit Tippareddy, Debra McGivney, Dan Ma, Mark Griswold, Jeffrey Sunshine, Vikas Gulani, Jill S. Barnholtz-Sloan, Andrew E. Sloan, Chaitra Badve
Summary: This radiomics study investigates the potential of texture analysis on MRF maps to distinguish intra-axial adult brain tumors and predict survival in glioblastoma patients. By analyzing texture features on T1 and T2 maps, the study found that certain features can differentiate different tumor types and predict outcomes in glioblastoma patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Jiaying Liu, Randall Toy, Casey Vantucci, Pallab Pradhan, Zijian Zhang, Katie M. Kuo, Kelsey P. Kubelick, Da Huo, Jianguo Wen, Jinhwan Kim, Zhiheng Lyu, Simran Dhal, Alexandra Atalis, Shohini K. Ghosh-Choudhary, Emily J. Devereaux, James C. Gumbart, Younan Xia, Stanislav Y. Emelianov, Nick J. Willett, Krishnendu Roy
Summary: SNAbs are a synthetic, multivalent Janus nanotherapeutic platform that efficiently targets and depletes myeloid-derived immune-suppressor cells (MDSCs) in mouse-tumor and rat-trauma models. Injection of MDSC-targeting SNAbs in a mouse triple-negative breast cancer model successfully depletes circulating MDSCs, allowing enhanced infiltration of T cells and Natural Killer cells into tumors.
Review
Engineering, Biomedical
Morgan E. Lorkowski, Prabhani U. Atukorale, Ketan B. Ghaghada, Efstathios Karathanasis
Summary: Recent advancements have emphasized the importance of a holistic approach in cancer treatment, with iron oxide nanoparticles showing promise in seeking, sensing, and attacking solid tumors. These nanoparticles can be integrated with various stimulus mechanisms for the development of effective cancer therapy, co-delivering potent anticancer therapeutics and immune modulators. Future directions for clinical translation are also considered.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
M. E. Lorkowski, P. U. Atukorale, P. A. Bielecki, K. H. Tong, G. Covarrubias, Y. Zhang, G. Loutrianakis, T. J. Moon, A. R. Santulli, W. M. Becicka, E. Karathanasis
Summary: Pancreatic ductal adenocarcinoma is a highly malignant disease with poor outcomes even with aggressive chemotherapy, however, immunotherapy shows promise in eliciting T cell-mediated killing of tumor cells. The immunotherapeutic approach developed in this study effectively activates and expands antigen-presenting cells in tumors, leading to an increase in IFN beta production and expansion of dendritic cells and lymphocyte infiltration, offering a potential new treatment avenue for PDAC.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sherry S. Huang, Rasim Boyacioglu, Reid Bolding, Christina MacAskill, Yong Chen, Mark A. Griswold
Summary: A free-breathing abdominal MRF technique was proposed for quantitative mapping in the abdomen, providing simultaneous quantification of multiple tissue properties in a single acquisition without breath-holding or patient set-up. Phantom and in vivo studies demonstrated accurate acquisition of T1 and T2 values with good agreement compared to reference values. The integration of PT navigator with MRF reconstruction enabled quantitative imaging in the abdomen with retrospective gating of respiratory motion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Charit Tippareddy, Walter Zhao, Jeffrey L. Sunshine, Mark Griswold, Dan Ma, Chaitra Badve
Summary: Magnetic resonance fingerprinting is an evolving quantitative MRI framework capable of simultaneously producing multiple high-resolution property maps. Despite being a relatively new technology, MRF has rapidly developed for various clinical applications such as brain tumor characterization and prostate cancer characterization.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrienne E. Campbell-Washburn, Yun Jiang, Gregor Koerzdoerfer, Mathias Nittka, Mark A. Griswold
Summary: The study demonstrated the feasibility of whole-brain T1 and T2 mapping using MR fingerprinting on a 0.55 T MRI system, with validated accuracy and repeatability despite lower signal-to-noise ratio. The method was successful for quantitative imaging even in lower magnetic field strengths.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christina J. MacAskill, Michael Markley, Susan Farr, Ashlee Parsons, Jacob R. Perino, Kimberly McBennett, Katherine Kutney, Mitchell L. Drumm, Nicole Pritts, Mark A. Griswold, Dan Ma, Katherine M. Dell, Chris A. Flask, Yong Chen
Summary: The study evaluated a rapid kidney MRF technique at 3.0 T in phantoms, healthy volunteers, and patients, demonstrating its accuracy and reliability in assessing kidney T1 and T2 parameters through experiments on standardized phantoms, healthy adult volunteers, and pediatric patients with kidney disease.
Article
Chemistry, Multidisciplinary
Prabhani U. Atukorale, Taylor J. Moon, Alexandr R. Bokatch, Christina F. Lusi, Jackson T. Routhier, Victoria J. Deng, Efstathios Karathanasis
Summary: This study evaluated the efficacy of neoadjuvant combination immunotherapy in treating aggressive cancer by combining the anti-PD1 checkpoint inhibitor with immunostimulatory nanoparticles. The results showed that the combination treatment activated the immune system, significantly improving tumor clearance and inducing protective immune memory.
Article
Materials Science, Biomaterials
Gil Covarrubias, Taylor J. Moon, Georgia Loutrianakis, Haley M. Sims, Mayura P. Umapathy, Morgan E. Lorkowski, Peter A. Bielecki, Michelle L. Wiese, Prabhani U. Atukorale, Efstathios Karathanasis
Summary: A novel immunostimulatory nanoparticle was developed to reprogram tumor antigen-presenting cells and activate cytotoxic T cells in the tumor microenvironment, showing potential for inhibiting tumor growth. Both untargeted nanoparticles and integrin-targeting nanoparticles exhibited significant immune responses and long-lasting antitumor effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Gil Covarrubias, Morgan E. Lorkowski, Haley M. Sims, Georgia Loutrianakis, Abdelrahman Rahmy, Anthony Cha, Eric Abenojar, Sameera Wickramasinghe, Taylor J. Moon, Anna Cristina S. Samia, Efstathios Karathanasis
Summary: The use of IONP-induced hyperthermia has a significant impact on tumor-resident immune cell subpopulations and systemic delivery approach showed superior outcomes in reducing both innate and adaptive immune cells within the tumor. Following the depletion of dysfunctional tumor-resident immune cells, treatment with immune checkpoint inhibitors encouraged the repopulation of the tumor with 'fresh' infiltrating innate and adaptive immune cells, resulting in a significant decrease of the tumor cell population.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Wyatt M. Becicka, Peter A. Bielecki, Morgan E. Lorkowski, Taylor J. Moon, Yahan Zhang, Prabhani U. Atukorale, Gil Covarrubias, Efstathios Karathanasis
Summary: Immunostimulatory silica mesoporous nanoparticles (immuno-MSN) were developed to reprogram tumor-resident innate immune cells and enhance interferon production. The degree of PEGylation significantly influenced the uptake of 'empty' MSNs by tumor-resident innate immune cells, but not for the agonist-loaded immuno-MSN variants. Finding a balance between immune evasion and uptake by target immune cells is key in designing PEGylated immunostimulatory nanoparticles.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Physical
Peter A. Bielecki, Morgan E. Lorkowski, Wyatt M. Becicka, Prabhani U. Atukorale, Taylor J. Moon, Yahan Zhang, Michelle Wiese, Gil Covarrubias, Shruthi Ravichandran, Efstathios Karathanasis
Summary: The study focused on using an immunostimulatory mesoporous silica nanoparticle, termed immuno-MSN, to boost the local innate immune compartment of GBM and enhance the antitumor immune response, resulting in elevated pro-inflammatory effects.
NANOSCALE HORIZONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rasim Boyacioglu, Charlie Wang, Dan Ma, Debra F. McGivney, Xin Yu, Mark A. Griswold
Summary: The study introduced 3D magnetic resonance fingerprinting (MRF) with quadratic RF phase (qRF-MRF) for simultaneous quantification of T1, T2, Delta B0, and T2*. The combination of randomized singular value decomposition (rSVD) and quadratic interpolation method allowed for feasible processing of prohibitively large data sets.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)