期刊
JOURNAL OF CONTROLLED RELEASE
卷 172, 期 1, 页码 281-291出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2013.08.022
关键词
Drug delivery; Spatial-temporal sequence; Systemic targeting; Intracellular targeting; Stimuli-responsive
资金
- National Natural Science Foundation of China [31300786, 31240007]
- Shandong Youth Scientist Awards Foundation [BS2012SW024]
- Programs Foundation of Ministry of Education of China [20120132120011]
In cancer therapy, drug delivery is a complex process that aims to transit the cargo to the destination with as little damage to the normal tissue as possible. In the last decade, tremendous development and research on nanomedicine have been exploring an ideal system with efficient drug transportation and release property. For this end, series of barriers need to be circumvented by nanomedicine, including systemic barriers, such as biosurface adsorption, phagocytic clearance, bloodstream washing, interstitial pressure, degradation, as well as intracellular barriers, such as cell membrane reorganization and internalization, endo/lysosomal escape, cytosolic or subcellular localization. Rather than being random, these barriers follow a specific spatial-temporal sequence. Therefore, the nanocarriers have to be endowed with characteristics that are adaptive to particular biological milieu on systemic and intracellular levels. To this end, we reviewed the correlations between the spatial-temporal sequences of drug delivery and nanocarrier characteristics in cancer therapy, as well as strategies to achieve efficient drug delivery upon both systemic and intracellular levels. (C) 2013 Published by Elsevier B.V.
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