Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Polymer Science
Huafen Wang, Huanhuan He, Jiaxiang Zhang, Juntao Liu, Yuwei Zhuang, Yuanyuan Yin, Zhiyong Ren, Yang Fu, Suqin He
Summary: Novel monomethoxy poly(ethylene glycol) modified hydroxylated tung oil (mPEG-HTO-mPEG) was synthesized as a drug delivery system. The properties of mPEG-HTO-mPEG were affected by the length of the mPEG chain. The drug loading and release behaviors of mPEG-HTO-mPEG with prednisone acetate as a model drug were investigated, and the results showed effective loading and sustained release.
Article
Biochemistry & Molecular Biology
Keni Yang, Karolina Tran, Anna Salvati
Summary: Ideal drug carriers should maintain stability in biological environments and release drugs once inside targeted cells. However, balancing these two aspects can be challenging. This study combined kinetic studies, aging experiments, and chromatography to determine drug release profiles in biological environments and cells, using liposomes as model nanomedicines. The results demonstrated that liposome stability and intracellular release kinetics could be controlled by changing the lipid composition.
Article
Polymer Science
Kirill A. Kirshanov, Roman V. Toms, Mikhail S. Balashov, Sergey S. Golubkov, Pavel V. Melnikov, Alexander Yu. Gervald
Summary: Polymer composites with similar properties to PET-based polyester matrices can be obtained by purifying the products of PET glycolysis. A kinetic model of PET homogeneous glycolysis was proposed and verified by experimental data. The model can be used to predict optimal conditions for PET glycolysis and obtain composite materials with desired properties.
Article
Pharmacology & Pharmacy
Wioletta Liwinska, Ewelina Waleka-Bagiel, Zbigniew Stojek, Marcin Karbarz, Ewelina Zabost
Summary: Enzyme-responsive polymeric-based nanostructures show potential as targeted drug delivery carriers, but their major risks are the fast disassembling of short-lived structures and limited accessibility of the enzyme to internal moieties. A modified environmentally responsive and enzymatically cleavable nanogel carrier was developed, which allowed independent shrinking of different parts of the network and targeted interaction with cellular receptors. Tunable nanogels efficiently stored and triggered the release of doxorubicin and mitoxantrone, with enhanced enzymatic degradation by introducing more hyaluronidase enzyme.
Article
Biochemistry & Molecular Biology
Irina M. Le-Deygen, Oxana E. Musatova, Victor N. Orlov, Nikolay S. Melik-Nubarov, Irina D. Grozdova
Summary: This study provides the first evidence of the interaction between PEG and HA in aqueous solutions. The binding of PEG to HA requires multiple free primary hydroxyls regularly distributed along the polysaccharide chain. Additionally, PEG-induced compaction of HA may be related to changes in plasma membrane properties and resealing of mechanical injuries.
Article
Chemistry, Physical
Amir Erfani, Abanoub Hanna, Payam Zarrintaj, Saeed Manouchehri, Katie Weigandt, Clint P. Aichele, Joshua D. Ramsey
Summary: This study successfully synthesized a biodegradable zwitterionic poly(carboxybetaine) microgel for encapsulating and releasing antibodies, demonstrating good cell compatibility. The released antibodies from the microgel were highly active, suitable for localized antibody delivery with minimized non-specific interactions.
Article
Biochemistry & Molecular Biology
Miao Zhang, Zhongxing Zhang, Xia Song, Jingling Zhu, Jing An Sng, Jun Li, Yuting Wen
Summary: In this study, an amphiphilic polymer composed of a hydrophobic palmitoyl group and a zwitterionic pMPC block was synthesized and characterized for applications in drug delivery systems. The polymer exhibited the ability to form stable micelles with enhanced drug loading capacity and cellular uptake efficiency. The DOX-loaded micelles showed a more efficient anticancer effect in multidrug-resistant cancer cells.
Article
Materials Science, Multidisciplinary
Paul J. Molino, Richard E. Wetherill, Allen Knepper, Desire Trupia, Patricia Hayes, Binbin Z. Molino, Timothy W. Hanks
Summary: The study revealed that surface derivatization of polypyrrole films can reduce a portion of the film, freeing up some dopant counterions while forming a brush-like layer to resist protein adhesion. The action of proteins may trigger the release of dopants, with an electrostatic mechanism likely being the main driving force behind the measured release.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Xiangjun Meng, Zhi Zhang, Jin Tong, Hui Sun, John Paul Fawcett, Jingkai Gu
Summary: The in vivo fate of PEG-PLA was investigated in rats, showing that PEG-PLA is mainly excreted in urine as its PEG metabolite. This will help facilitate the scientific design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Polymer Science
Graham Hayes, Ben Drain, C. Remzi Becer
Summary: Poly(2-oxazoline)s are promising for biomedical applications, but limited synthetic approaches exist for star-shaped polymers. A novel bis-oxazoline cross-linker was developed via a fast thiol click reaction, allowing the preparation of well-controlled core cross-linked star polymers. The synthesized star-shaped polymers were characterized extensively and showed potential for encapsulation of dihydroxyanthroquinone.
Article
Pharmacology & Pharmacy
Nina Dragicevic, Bojan Nikolic, Volker Albrecht, Alfred Fahr
Summary: Invasomes can enhance the skin penetration of mTHPC and deliver it to tumors, making them a potential option for topical PDT. The study also confirmed transdermal mTHPC delivery and suggested the possibility of using invasomes for diseases requiring systemic drug absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Lukas P. Sadowski, Andrew Singh, Daniel H. Luo, Michael J. Majcher, Ivan Urosev, Meghan Rothenbroker, Vitaliy Kapishon, Niels M. B. Smeets, Todd Hoare
Summary: In this study, brush co-polymer analogues were synthesized via atom transfer radical polymerization (ATRP) and used to fabricate nanoparticles for drug delivery applications. These analogues exhibited high colloidal stability, favorable in vitro cytocompatibility, and effective drug loading. The functionalization of the hydrophobic block allowed for controlled release of the nanoparticles.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Moein Zarei, Miroslawa El Fray
Summary: Polymeric materials have a wide range of applications due to their controllable properties. In this study, a series of PBS-DLS-PEG copolymers were synthesized with different molecular weights of PEG to investigate their surface and thermal properties. The incorporation of higher molecular weight PEG improved the surface wettability of the materials while maintaining their thermal properties.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)